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1. Clinical significance of lymphocyte-platelet adhesion, cytokines and endothelial dysfunction in the development of gestational hypertension

Creator:
Matyakubova, Salomat Aleksandrovna
Format:
electronic, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, hodnotící studie, and TEXT
Subject:
hypertenze indukovaná těhotenstvím--etiologie--patofyziologie--patologie, trombocyty - adhezivita, cytokiny--krev, endoteliální buňky, endotel--patologie, TNF-alfa--krev, lymfocyty--patologie, interleukiny--krev, rizikové faktory, oxid dusný--krev, mladiství, dospělí, ženské pohlaví, lidé, těhotenství, kohortové studie, and statistika jako téma
Language:
English
Description:
The aim of our study was to determine the significance of lymphocyte-platelet adhesion (LPA), interleukins, transforming included 139 pregnant women aged between 17 and 27 years (21.3±4.22 years). GH was diagnosed in 119 women after 20 weeks of pregnancy. 20 patients (control group) were with physiological course of pregnancy. The distribution of patients by groups was carried out according to the level of blood pressure (BP) in accordance with ICD-10 (Geneva, WHO, 2002). The survey was conducted at the moment of detection pregnancy from 7 to 10 weeks and in dynamics of I, II and III trimesters of gestation. In the dynamics of gestation, were studied the number of desquamated endothelial cells circulating in the systemic circulation (CECs), nitrates levels, the adhesion of platelets by estimation their ability to form co-aggregates with lymphocytes by determining the percentage of lymphocytes aggregates with thrombocytes (lymphocyte-platelet plugs), at risk of hypertensive disorders, especially after 20-22 weeks of gestation and later, lymphocytes ability to platelets adhesion is rose, the concentrations of pro-inflammatory cytokines and NO level are increased. The direct relationship indicates their importance in the pathogenesis of hypertensive disorders in pregnant women., Salomat Aleksandrovna Matyakubova, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

2. Use of enzymes in complex treatment of antiphospholipid syndrome in women with reproductive losses of andijan state

Creator:
Maniyozova, Gulnoza, Negmatshaeva, Habiba, Yuldasheva, Ozoda, Turaeva, Gulnoza, and Parpieva, Dilfura
Format:
electronic, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, hodnotící studie, and TEXT
Subject:
antifosfolipidový syndrom--etiologie--farmakoterapie--krev, potrat spontánní--prevence a kontrola, komplikace těhotenství--prevence a kontrola, fibrinolytika--terapeutické užití, antiflogistika--terapeutické užití, enzymová terapie--metody--statistika a číselné údaje, antioxidancia--terapeutické užití, hemostáza--účinky léků, kohortové studie, ženské pohlaví, lidé, těhotenství, výsledek terapie, and Serrata
Language:
English
Description:
Background: Obstetric complications developing at antiphospholipid syndrome are serious medical-social problem. Seeking of the treatment methods sets conditions for urgency of the article reviewed. Enzyme preparations are widely applied for treatment of women with fecundity disorder and hemorheology changes. Research objective was in clinico-laboratorial evaluation of Serrata drug impact in antiphospholipid syndrome in women with reproductive losses of Andijan state. Methods: Data of 43 women in the non-pregnancy state with reproductive losses (RL) in past history with revealed APS had been studied by us. Results: Thus, conducted therapy with Serrata was conductive to haemostasis. Conducted researches confirm the safety of application., Gulnoza Maniyozova, Habiba Negmatshaeva, Ozoda Yuldasheva, Gulnoza Turaeva, Dilfura Parpieva, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public