The eigenvalues of graphs are related to many of its combinatorial properties. In his fundamental work, Fiedler showed the close connections between the Laplacian eigenvalues and eigenvectors of a graph and its vertex-connectivity and edge-connectivity. We present some new results describing the connections between the spectrum of a regular graph and other combinatorial parameters such as its generalized connectivity, toughness, and the existence of spanning trees with bounded degree., Sebastian M. Cioabă, Xiaofeng Gu., and Obsahuje seznam literatury
Left ventricular hypertrophy (LVH) is due to pressure overload or mechanical stretch and is thought to be associated with remodeling of gap-junctions. We investigated whether the expression of connexin 43 (Cx43) is altered in humans in response to different degrees of LVH. The expression of Cx43 was analyzed by quantitative polymerase chain reaction, Western blot analysis and immunohistochemistry on left ventricular biopsies from patients undergoing aortic or mitral valve replacement. Three groups were analyzed: patients with aortic stenosis with severe LVH (n=9) versus only mild LVH (n=7), and patients with LVH caused by mitral regurgitation (n=5). Cx43 mRNA expression and protein expression were similar in the three groups studied. Furthermore, immunohistochemistry revealed no change in Cx43 distribution. We can conclude that when compared with mild LVH or with LVH due to volume overload, severe LVH due to chronic pressure overload is not accompanied by detectable changes of Cx43 expression or spatial distribution., C. Vetter ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
We assessed the effect of the previously uncovered gap junctio n protein alpha 8 (Gja8) mutation present in spontaneously hypertensive rat - dominant cataract (SHR - Dca ) strain on blood pressure, metabolic profile, and heart and renal transcriptomes. Adult, standard chow-fed male rats of SHR and SHR - Dca strains were used. We found a significant, consistent 10-15 mmHg decrease in both systolic and diastolic blood pressures in SHR - Dca compared with SHR (P<0.01 and P<0.05 , respectively; repeated measures analysis of variance (ANOVA)). With immunohistochemistry, we were able to localize Gja8 in heart, kidney, aorta, liver, and lungs, mostly in endothelium; with no differences in expression between strains. SHR - Dca rats showed decreased body weight, high-density lipoprotein cholesterol concentrations and basa l insulin sensitivity in muscle. There were 21 transc ripts common to the sets of 303 transcripts in kidney and 487 in heart showing >1.2-fold difference in expression between SHR and SHR - Dca. Tumor necrosis factor was the most significant upstream regulato r and glial cell-derived neurotrophic factor family ligand-receptor interactions was the common enriched and downregulated canonical pathway both in heart and kidney of SHR - Dca. The connexin 50 mutation L7Q lowers blood pressure in the SHR - Dca strain, decr eases high-density lipoprotein cholesterol, and leads to substantial transcriptome changes in heart and kidney., O. Šeda, F. Liška, M. Pravenec, Z. Vernerová, L. Kazdová, D. Křenová, V. Zídek, L. Šedová, M. Krupková, V. Křen., and Obsahuje bibliografii
This paper focuses on the consensual security rights over the objects of intellectual property in the Czech Republic. The paper is based on the national report presented for the purpose of XX. Congress of the International Academy of Comparative Law (Japan, Fukuoka, 22-28 July 2018). In the first part of the paper, the authors describe the system of the intellectual property protection and explain the basic principles of the core sstems of IP protection: copyrights, patents, trademarks and industrial designs. in the next part the authors define three most common methods of the security rights over the intangible assets: a pledge, transfer of a right as a security, and a prohibition of the alienation or the encumbrance of assets. The paper subsequently deals with the following issues: typical structure of the security transaction, mechanisms of evaluating the IP rights used as collateral, and requirements needed for the effectiveness of security rights. With this regard the authors distinguish between the effects of the security rights over non-registered rights such as copyright or unregistered designs, and security rights over registered trademarks, granted patents or registered industrial designs. Special attention is paid to the security rights over the business enterprise. The final part of the paper is aimed at the statistical analysis. The authors describe how frequent is the use of the consensual security rights in Czech legal practice and what are the usual costs related to the secured transactions over the intellectual property., Pavel Koukal, Helena Pullmannová., and Obsahuje bibliografické odkazy
As part of a modern review of all Australian Collembola families, a key is provided to the nine genera of Brachystomellidae currently known from Australia, their morphology is compared, their distribution within and outside Australia is noted and the high diversity of genera in southern regions emphasised. Three Australian genera are endemic, five are also found in South America, South Africa and/or New Zealand and one has a cosmopolitan distribution. The distribution, ecology and habitat preferences of Australian genera are compared. Two genera, Cassagnella Najt & Massoud and Rapoportella Ellis & Bellinger, are newly diagnosed and additions to the description of C. anomala Womersley are given. Australian Cassagnella species appear restricted to southern, humid regions and C. anomala possesses some characters that indicate it is adapted to living in habitats that are periodically flooded. A new species, Rapoportella edwardi sp. n. is described in the rarer genus from drier eucalypt forests. The effect of agricultural practices on an introduced species of Brachystomella is noted and its indicator value emphasised. Possible threats to the endemic genera and species are noted., Penelope Greenslade., and Obsahuje bibliografii
Práce vznikla jako součást projektu zabývajícího se zkoumáním konstantnosti větných členů mezi angličtinou a češtinou. Cílem výzkumu je ověřit hypotézu o univerzální platnosti principu koncového postavení jádra výpovědi. Vzhledem k odlišné typologické charakteristice angličtiny očekáváme, že pro zachování téhož lineárního uspořádání prvků výpovědi bude užívat odlišné syntaktické struktury.
Vc směru z angličtiny do češtiny byly nejčastčjšími nekorespondujícími ekvivalenty předmětu české adverbiale, přísudek a podmět. Vzhledem к volnému slovosledu češtiny zde ovšem aktuální členění větné nepatřilo mezi přímo působící faktory, jeden z hlavních faktorů je však tendencí к základnímu rozložení VD podmíněn. Naopak ve směru z češtiny do angličtiny bylo AČV zásadním faktorem změny předmětu v podmět, jež tvořila téměř polovinu všech případů, a přispívalo rovněž к disociaci slovesného přísudku. Rozložení stupňů výpovědní dynamičnosti zůstalo v obou směrech většinou zachováno a blížilo se základnímu rozložení VD. Výsledky práce potvrzují zkoumanou hypotézu.