The 14-3-3 proteins are a family of acidicr egulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase., V. Obšilová, J. Šilhan, E. Bouřa, J. Teisinger, T. Obšil., and Obsahuje bibliografii a bibliografické odkazy
Speleothems in 6 sandstone caves in the Bohemian Paradise (Český ráj) were dated by means of 14C and U-series methods. Stable isotopes of C and O, FAAS, IR, XRD, XRF and SEM were used to characterize the carbonate material and its source. Stable isotopes (C and O) composition of speleothems in two caves corresponds to values characteristic for cave speleothems in Central Europe. In other caves they indicate evaporation and fast carbon dioxide escape during carbonate precipitation. The speleothems from the Krtola Cave were deposited between 8 and 13 kyr BP. Speleothems were deposited 5-8 kyr BP in the Sintrová, Mrtvé Údolí and U Studánky caves. Calcite coatings on smooth sandstone surfaces in studied caves demonstrate that cave walls did not retreat even a few mm in the last 5-8 kyr since speleothem deposition and are thus not evolving under recent climatic conditions. Most of the cave ceilings and walls are at present time indurated by hardened surfaces, which protect the sandstone from erosion. Sandstone caves probably intensively evolved either during or at the end of the Last Glacial period. There are two different erosion mechanisms which might have formed/reshaped the caves at that time: A) In the case of permafrost conditions: Repeated freeze/melt cycles affecting sandstone pore space followed by the transport of fallen sand grains by minor temporary trickles. We expect that heat was transmitted by air circulating between the cave and the surface; B) Seepage erosion of sandstone during the melting of permafrost, prior forming of case hardening., Jiří Bruthans, Jana Schweigstillová, Petr Jenč, Zdeňka Churáčková and Petr Bezdička., and Obsahuje bibliografii
Odlupováním vrstevnatých materiálů (např. grafitu) lze připravit 2D krystaly s tloušťkou jednoho nebo několika málo atomů. Nejznámějším takovým 2D materiálem je grafen (monovrstva grafitu), nicméně v současnosti existují a intenzivně se zkoumají desítky podobných struktur. Příspěvek podává základní přehled o 2D materiálech, jejich vlastnostech, metodách přípravy a možných aplikacích., Layered materials (such as graphite) can be exfoliated to produce 2D crystals with a thickness of one of just a few atoms. The best known 2D material is graphene (monolayer of graphite), yet there are tens of similar structures, which are being studied intensively at the moment. This article presents a brief summary of 2D materials, their properties, methods of preparation and potential application., Zdeňka Hájková, Martin Ledinský, Matěj Hývl, Aliaksei Vetushka, Antonín Fejfar, Jaroslava Řáhová, Otakar Frank., and Obsahuje bibliografické odkazy