Denosumab is a human monoclonal antibody representing a novel therapy of osteoporosis. Contrary to always other antiosteoporotic drugs, it is not contraindicated in advanced chronic kidney disease, as its pharmacokinetic does not differ from patients with normal kidney function. However, published case reports in chronic kidney disease (CKD) patients stopped the therapy after single dose because of hypocalcemia. We present a case of successful treatment of osteoporosis in a young hemodialysis patient with repeated denosumab doses. and Sylvie Dusilová Sulková, Jiří Horáček, Roman Šafránek, Petr Gorun, Ondřej Viklický, Vladimír Palička
A classical result in number theory is Dirichlet’s theorem on the density of primes in an arithmetic progression. We prove a similar result for numbers with exactly k prime factors for k>1. Building upon a proof by E.M.Wright in 1954, we compute the natural density of such numbers where each prime satisfies a congruence condition. As an application, we obtain the density of squarefree n 6 x with k prime factors such that a fixed quadratic equation has exactly 2k solutions modulo n., Neha Prabhu., and Seznam literatury
Estimating the spatial dispersion of pest arthropods is crucial for the development of reliable sampling programs and one of the main components of integrated pest management. The natural spatial distribution of a population of a species may be random, uniform, or aggregated and can be so classified based on calculation of variance to mean relations and related dispersion indices. In this work some classical density-invariant dispersion indices and related regression models are used for the first time to quantify the spatial dispersion of an important peach pest Anarsia lineatella Zeller (Lepidoptera: Gelechiidae) and construct fixed precision sequential sampling schemes. Taylor's power law, Iwao's patchiness regression and Nachman's model were used to analyse the damage to peaches caused by A. lineatella. All three regression models fit the data well, although the results indicate that Iwao's patchiness model provides a better description of the relationship between variance and mean density. Taylor's b and Iwao's b regression indices were both significantly smaller than 1, indicating that the distribution of individuals was uniform rather than random or aggregated. According to Green's and Kuno's models, the minimum sample size at the precision level of 0.2 varies from 3 samples, when total population density is more than 3 larvae/sample, to 10 samples, when population density is between 1 and 2 larvae/sample. Kuno's fixed sampling plan indicates that a small number of samples (i.e., 3-10 branches with fruit) is sufficient to estimate the mean population density of A. lineatella larvae with a precision of 0.2. The Resampling for validation of sampling plans (RVSP) method confirmed that the average level of precision of the fixed sequential plans matched the desired precision in most cases. The sampling plan presented here provides a level understanding of A. lineatella spatial ecology suitable for pest manage, Petros Damos., and Obsahuje bibliografii
BACKGROUND: Human immunodeficiency virus (HIV) continues to be a serious health issue and one of the world most devastating epidemics. An estimated 1.5 million people died from AIDS-related illnesses in 2013, and an estimated 37 million people with AIDS have died worldwide since the epidemic has begun. HIV infection is known for its oral manifestations which causes discomfort and pain for infected individuals. The objective of this study was to document oral conditions of HIV positive patients and the pattern and frequency of oral and dental lesions. METHODS: All patients with confirmed HIV infection who were treated at the Department of Dentistry, University Hospital in Hradec Králové, were examined. RESULTS: During the study period, 29 HIV positive patients were examined and treated--19 men, 10 women, with mean age of 32.9 years (range 22-58 years). 72.41% patients received ART. In total, all patients underwent 186 visits. The most frequent treatments were associated with teeth and periodontal lesions (71.80%), oral mucosal lesions were diagnosed and treated only in 3.96% cases. CONCLUSION: Since the introduction of ART, the frequency of oral mucosal lesions is minimal in patients with HIV infection. and M. Šembera, V. Radochová, R. Slezák
Let $\Delta_{n,d}$ (resp. $\Delta_{n,d}'$) be the simplicial complex and the facet ideal $I_{n,d}=(x_1\cdots x_d,x_{d-k+1}\cdots
x_{2d-k},\ldots,x_{n-d+1}\cdots x_n)$ (resp. $J_{n,d}=(x_1\cdots x_d,x_{d-k+1}\cdots x_{2d-k},\ldots,x_{n-2d+2k+1}\cdots x_{n-d+2k},x_{n-d+k+1}\cdots x_nx_1\cdots x_k)$). When $d\geq2k+1$, we give the exact formulas to compute the depth and Stanley depth of quotient rings $S/J_{n,d}$ and $S/I_{n,d}^t$ for all $t\geq1$. When $d=2k$, we compute the depth and Stanley depth of quotient rings $S/J_{n,d}$ and $S/I_{n,d}$, and give lower bounds for the depth and Stanley depth of quotient rings $S/I_{n,d}^t$ for all $t\geq1$., Xiaoqi Wei, Yan Gu., and Obsahuje bibliografické odkazy
Josef Schramek, Obr. příl., Obsahuje rejstřík, S předmluvou vydavatele, S autotypiemi a kresbami, Böhmerwaldholzhauer (Anhang), and Converted from MODS to DC version 1.8 (EE patch 2018/05/24)