This article focuses on military handbooks from the first half of the 17th century placed in the collections of the Military History Institute Prague. In the introduction, it summarises the history and structure of the collection of early printed books in the library under study. After that, it characterises the set of the handbooks i.a. in terms of their topic, the language and the publisher’s provenance, as well as format. Its main aim is to analyse the frontispieces and engraved title pages of these publications with regard to the iconographic motifs that are usually depicted on them. The final part of the work outlines the possibilities of using the frontispieces and engraved title pages of the studied publications as iconographic sources in historiography and it places the title illustrations of the military handbooks in a wider context., Klára Andresová., Obsahuje anglický abstrakt a shrnutí., and Obsahuje bibliografii
Advanced glycation end-products (AGEs) are key players in pathogenesis of long-term vasc ular diabetes complications. Several enzymes such as fructosamine 3-kinase (FN3K) and glyoxalase I (GLO I) are crucial in preventing glycation processes. The aim of our study was to evaluate an association of FN3K (rs1056534, rs3848403) and GLO1 rs4746 polymorphisms with parameters of endothelial dysfun ction and soluble receptor for AGEs (sRAGE) in 595 diabetic and non-diabetic subjects. Genotypic and allelic frequencies of mentioned polymorphisms did not differ between subgroups. In diabetic patients significant differences were observed in sRAGE concentrations according to their rs1056534 and rs3848403 genotype. While GG and CG genotypes of rs1056534 with mutate d G allele were associated with significant decrease of sRAGE (GG: 1055±458 and CG: 983±363 vs. CC: 1796±987 ng/l, p<0.0001), in rs3848403 polymorphism TT genotype with mutated T allele was related with significant sRAGE increase (TT: 1365±852 vs. CT: 1016±401 and CC: 1087±508 ng/l, p=0.05). Significant differences in adhesion molecules were observed in genotype subgroups of GLO1 rs4746 polymorphism. In conclusion, this is the first study describing significant relationship of FN3K (rs1056534) and (rs3848403) polymorphisms with concentration of sRAGE in patients with diabetes., J. Škrha Jr., A. Muravská, M. Flekač, E. Horová, J. Novák, A. Novotný, M. Prázný, J. Škrha, J. Kvasnička, L. Landová, M. Jáchymová, T. Zima, M. Kalousová., and Obsahuje bibliografii
In addition to providing subsistence and consumable resources, one of the most important features of water is the ability to provide transport and communication between geographically separated areas. In both uses, vehicles play a key role. While current research into boats and ships on the seas is relatively well recognised, recent results in the area of inland waterways seem to be barely taken into account in current investigations. Too foten scientist have to rely on an otdate state of research, but in fact several findings have laterl been re-edited and presented. This article provides an updated look at the subject of inland navigation in the Early and Hig Middle Ages and focuses especially on current pbuliactions or those that are difficult to obtain. Further, an overview on the state of research in neighbouring countries is offered, thereby presenting a fuller view of the subject´s potentional., Lars Kröger., and Obsahuje seznam literatury