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Start Over Format print Subject Patologie. Klinická medicína

32. O významu pohlavních nemocí pro ženu, rodinu a společnost

Creator:
Václav Rubeška and Česká eugenická společnost
Publisher:
Nakladatelství J. Otto
Format:
print, svazek, and 20 stran.
Type:
model:monograph and TEXT
Subject:
Patologie. Klinická medicína, sexuálně přenosné nemoci, sociální aspekty, sexually transmitted diseases, social aspects, 14, and 616
Language:
Czech
Description:
Václav Rubeška., (Předneseno v lidových přednáškách c.k. České university v Praze v kursu 1916, pořádaném péčí České eugenické společnosti v Praze), and Přívazek k : Jaroslav Kříženecký / Ochrana mládeže a eugenika
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

33. Ošetřování nemocných: ku potřebě ošetřovatelek z povolání i širších kruhů

Creator:
Šťastný, Jaroslav and Panýrek, Duchoslav
Publisher:
Nakladatelství F. Šimáčka
Format:
print, text, regular print, and 152 s. : il. ; 21 cm
Type:
model:monograph and TEXT
Subject:
Patologie. Klinická medicína, ošetřovatelství, ošetřovatelská péče, nemocní, 616-083, 616-052, (035), 14, and 616
Language:
Czech
Description:
sepsali Jaroslav Šťastný a Duchoslav Panýrek, Obsahuje rejstřík, and Se 117 vyorazeími
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

35. Positive effect of oral supplementation with glycosaminoglycans and antioxidants on the regeneration of osteochondral defects in the knee joint

Creator:
Milan Handl, Evžen Amler, Bräun, K., Holzheu, J., Tomáš Trč, Imhoff, A. B., Lytvynets, A., Elena Filová, Hana Kolářová, Arnošt Kotyk, and Václav Martínek
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Patologie. Klinická medicína, experimentální medicína, chrupavka, experimental medicine, cartilage, glycosaminoglycans, oral supplementation, osteochondral lesion, 14, and 616
Language:
English
Description:
The effect of oral supplementation with glycosaminoglycans (GAG) and radical scavengers (vitamin E/selenium) on the regeneration of osteochondral defects was investigated in rabbits. After introduction of defined osteochondral defects in the knee joint, groups of ten animals were given a GAG/vitamin E/selenium mixture or a placebo (milk sugar) for 6 weeks. Following sacrifice, histological and histochemical analysis was performed. The amount of synovial fluid was increased in the placebo group, while the viscosity of the synovial fluid was significantly enhanced in the GAG group. The amount of sulfated GAG in the osteochondral regenerates (8.8±3.6 % vs. 6.0±5.6 %; p<0.03) was significantly higher in the GAG group. In both groups, the GAG amount in the cartilage of the operated knee was significantly higher than in the non-involved knee (p<0.05). Histological analysis of the regenerates in the GAG group was superior in comparison with the placebo group. For the first time, a biological effect following oral supplementation with GAG was demonstrated in healing of osteochondral defects in vivo. These findings support the known positive clinical results., M. Handl, E. Amler, K. Bräun, J. Holzheu, T. Trč, A. B. Imhoff, A. Lytvynets, E. Filová, H. Kolářová, A. Kotyk, V. Martínek., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

37. Pregnancy-associated plasma protein A and proform eosinophilic major basic protein in the detection of different types of coronary artery disease

Creator:
Petr Hájek, Milan Macek, Magdaléna Hladíková, Běla Houbová, David Alan, Václav Durdil, Jiří Fiedler, Martin Malý, Petr Ošťádal, Josef Veselka, and Alice Krebsová
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Patologie. Klinická medicína, kardiologie, věnčité tepny, troponiny, ateroskleróza, cardiology, coronary arteries, troponins, atherosclerosis, PAPP-A/proMBP, PAPP-A/proMBP (pregnancy-associated plasma protein A), 14, and 616
Language:
English
Description:
Kryptor system was proven to be a rapid, standard method for pregnancy-associated plasma protein A and proform eosinophilic major basic protein (PAPP-A/proMBP) complex detection in coronary artery disease (CAD). No age and/or gender differences in 51 controls and 110 stable coronary artery disease (SCAD) patients were found. SCAD patients did not differ from controls and no difference in PAPP-A/proMBP levels with regards to the number of affected vessels was found. In 21 unstable angina pectoris (UAP), in 35 without and 66 with ST elevation acute myocardial infarctions (NSTEMI, STEMI respectively) patients PAPP-A/proMBP levels were increased (P=0.004 and P<0.0005, respectively). PAPP-A/proMBP levels did not correlate with cardiac troponin I (cTnI) in STEMI and NSTEMI patients. PAPP-A/ proMBP increase was more frequent than cTnI (P=0.036) within the early phase of STEMI. In NSTEMI patients PAPP-A/proMBP positivity was present in 50 % of cTnI negative cases. Receiver operating characteristic (ROC) analysis revealed the highest diagnostic accuracy of PAPP-A/proMBP (0.919) in STEMI cTnI positive cases. The highest specificity/sensitivity PAPP-A/proMBP levels for particular acute coronary syndrome (ACS) types were 10.65-14.75 mIU/l. Combination of PAPP-A/proMBP with cTnI increases their diagnostic efficacy within the early phase of ACS. Our results suggest that PAPP-A/proMBP complex is involved in processes preceding vulnerable plaque development in ACS., P. Hájek, M. Macek, M. Hladíková, B. Houbová, D. Alan, V. Durdil, J. Fiedler, M. Malý, P. Ošťádal, J. Veselka,A. Krebsová., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

38. Příspěvek ku pathologii zánětů, nádorů a divertikulů červu

Creator:
Znojemský, Josef
Publisher:
nákladem vlastním
Format:
print and 109 s., xviii vyobr.
Type:
model:monograph and TEXT
Subject:
Patologie. Klinická medicína, divertikulóza střev, záněty, nádory, 14, and 616
Language:
Czech
Description:
J. Znojemský., S věnováním autora, Zvláštní otisk ze Sborníku lékařského, roč. XIII. (XVII.), č. 5-6, and Zadní desky nejsou k dispozici.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

39. Příspěvky k dějinám moru v zemích českých z let 1531-1746

Creator:
Václav Schulz and Česká akademie císaře Františka Josefa pro vědy, slovesnost a umění
Publisher:
Česká akademie císaře Františka Josefa pro vědy, slovesnost a umění
Format:
print and 274 s.
Type:
text, volume, dokumenty, prameny, model:monograph, and TEXT
Subject:
Patologie. Klinická medicína, Historická věda. Pomocné vědy historické. Archivnictví, 16.-18. stol, 1531-1746, mor, epidemie, lékařská péče, dějiny, archivní fondy, Česko, 616.98:579.842, 616-036.22, 616-082, 94(437.3), 930.253, (093), 14, 8, 616, and 930
Language:
Czech, German, and Latin
Description:
20, z archivu Musea království českého podává Václav Schulz., KČSN, and 2. přívazek k : Soudní akta konsistoře Pražské, část VI. / Ferdinand Tadra
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

40. Proteinase-activated receptor-2 expression in breast cancer and the role of trypsin on growth and metabolism of breast cancer cell line MDA MB-231

Creator:
Radoslav Matěj, Petra Manďáková, Irena Netíková Štenglová, Pavla Poučková, and Olejár, T.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Patologie. Klinická medicína, molekulární medicína, onkologie, rakovina prsu, molecular medicine, oncology, breast cancer, PAR-2, trypsin, proteinase-activated receptor-2 (PAR-2), 14, and 616
Language:
English
Description:
a1_Proteinase-activated receptor-2 (PAR-2) is a ubiquitous surface molecule participating in many biological processes. It belongs to the family of G protein-coupled receptors activated by the site-specific proteolysis of trypsin and similar proteases. Altered function of PAR-2 has been described in different malignant tumors. In the present study, we investigated the expression of PAR-2 in breast cancer surgical specimens and the role of trypsin in breast cancer cell line MDA MB-231 proliferation and metabolism. A total of 40 surgical samples of infiltrative ductal breast cancer and breast cancer cell line were included in this study. We analyzed PAR-2 expression by immunohistochemistry, RT-PCR and western blot. Activation of PAR-2 on cell line MDA MB-231 was measured using calcium mobilization assay determined by flow cytometry. MTT cell metabolism assay and cell count analysis were used to assess the trypsin influence on breast cancer cell line MDA MB-231 proliferation. Immunohistochemical examination showed the expression of PAR-2 in all samples of breast cancer surgical specimens and high levels of cell lines which was confirmed by RT-PCR and western blot., a2_Calcium mobilization assay corroborated the activation of PAR-2 on cell line MDA MB-231 either by trypsin or by an agonistic peptide. Cell metabolism assay and cell count analysis showed significant differences of proliferative activity of breast cancer cells dependent on the presence or absence of trypsin and serum in the culture medium. PAR-2 is expressed by high levels in infiltrative ductal breast cancer tissue specimens. PAR-2 is also strongly expressed in studied breast cancer cell lines. PAR-2 is activated by trypsin and also by agonistic peptide in the model of breast cancer cell line MDA MB-231. Activation of PAR-2 in vitro influences proliferative and metabolic activity of breast cancer cell line MDA MB-231. The action of trypsin is modified by the presence of serum which is a potential source of protease inhibitors., R. Matěj, P. Manďáková, I. Netíková, P. Poučková, T. Olejár., and Obsahuje biblografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

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