pro české hospodáře a hospodyně dle nejlepších a nejnovějších pramenů sepsal Jan K. Řezáč ; přispěním Leopolda Doležala ; druhé rozmnožené a doplněné vydání upravil Jan Datel, Vydáno péčí Spolku pro zvelebení chovu drobných domácích zvířat, and Converted from MODS 3.5 to DC version 1.8 (EE patch 2015/06/25)
návod k rozumnému chovu všeho druhu drůbeže s naučením o všech jejich odrůdách, nemocech a léčení : podrobné poučení o správném zařizování kurníků, jakož i vyzkoušené pokyny ku přirozenému a umělému líhnutí pro české hospodáře a hospodyně sepsal Jan K. Řezáč ; třetí vydání úplně přepracoval a moderními zkušenostmi doplnil Jan Krützner
In this review we summarize several synthetic approaches to the advanced synthesis of star-like polymer-based drug carriers. Moreover, their application as nanomedicines for therapy or the diagnosis of neoplastic diseases and their biodistribution are reviewed in detail. From a broad spectrum of star-like systems, we focus only on fully water-soluble systems, mainly based on poly(ethylene glycol) or N-(2-hydroxypropyl)methacrylamide polymer and copolymer arms and polyamidoamine dendrimers serving as the core of the star-like systems., L. Kotrchová, L. Kostka, T. Etrych., and Obsahuje bibliografii
Our previous studies have shown that the combined administration of drugs elevating extracellular adenosine, i.e. dipyridamole (DP) and adenosine monophosphate (AMP), enhances murine hematopoiesis and potentiates the action of granulocyte colony-stimulating factor (G-CSF). In this study, colony-stimulating activity (CSA) of blood serum of mice treated with DP+AMP, G-CSF or all these drugs in combination, i.e. the ability of the sera to stimulate the growth of GM-CFC colonies, was assayed in vitro. Furthermore, the concentration of GM-CSF and IL-6 in the sera was determined. Administration of DP+AMP was found to enhance significantly serum CSA at all time intervals of serum sampling including 24 h after the last injection of the tested drugs. Additive effects of DP+AMP and G-CSF on serum CSA were noted at early intervals after administration of the drugs. Furthermore, IL-6 levels were significantly elevated in the sera of mice which were administered DP+AMP either alone or in combination with G-CSF. Our results show that the effects of DP+AMP are indirect, mediated through the induction of some cytokine(s) and/or growth factor(s) and that extracellular adenosine can act in cooperation with G-CSF. These findings contribute to the further elucidation of the role of adenosine in hematopoiesis., L. Weiterová, M. Hofer, M. Pospíšil, V. Znojil, D. Štreitová., and Obsahuje bibliografii a bibliografické odkazy
In the final decade of the 20th century, reproductive behaviour in the Czech Republic underwent significant changes, which were manifested in, among other things, a decline in the birth rate. Views on the ideal number of children in a family have, conversely, remained consistent in the population over time, and the ideal of the two-child model has been repeatedly identified in sociological studies over the long term. Given the currently very low fertility rate and the continued postponement of childbirth to a later age, it is important to ask whether the proclaimed aspirations for a two-child family will be fulfilled and whether the tendency will be for women to actually have a second child. This article focuses on values associated with children and especially selected factors connected with the decision to have a second child, including an evaluation of the factors that women take into consideration when deciding to have more children. The analysis is based on data from the survey Men and Women in the Czech Republic: Life Courses and Inter-generational Relationships (GGS: Generations and Gender Survey), the first wave of which was conducted in the Czech Republic in 2005, and for the analysis focusing on a second child in the family selected generations of women were chosen.