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20762. Serum leptin levels in patients with sideropenic and pernicious anemia: the influence of anemia treatment
- Creator:
- Markéta Marková, Haluzík, M., Svobodová, J., Martina Rosická, Jara Nedvídková, and Haas, T.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, leptin, krvetvorba, anémie, kmenové buňky, hematopoiesis, anemia, stem cells, body mass index, blood count, 14, and 612
- Language:
- English
- Description:
- Leptin is a 16 kDa protein hormone involved in food intake, energy expenditure regulation and numerous other physiological processes. Recently, leptin has been demonstrated to stimulate hematopoietic stem cells in vitro. The aim of our study was to measure serum leptin and erythropoietin levels in patients with sideropenic (n =18) and pernicious anemia (n=7) before and during anemia treatment. Blood samples for the blood count, leptin and erythropoietin determinations were obtained by venepunction at the time of the diagnosis of anemia and after partial and complete anemia recovery. The relationships of serum leptin levels to erythropoietin levels and blood count parameters were also studied. No significant differences in serum leptin levels between the groups studied were found. The serum leptin levels in none of groups were modified by treatment of anemia (basal levels, the levels during treatment and after anemia recovery were 13.1±14.5 vs 12.8±15.6 vs 12.0±14.8 ng/ml in patients with sideropenic anemia and 7.8±8.5 vs 9.5±10.0 vs 8.9±6.6 ng/ml in patients with pernicious anemia). The erythropoietin levels were higher at the time of anemia in both groups and decreased significantly after partial or complete recovery. Serum leptin levels in both groups correlated positively with the body mass index. No significant relationships were found between serum leptin levels and erythropoietin values or various parameters of the peripheral blood count. We conclude that serum leptin levels in patients with sideropenic and pernicious anemia positively correlate with the body mass index but are not influenced by the treatment of anemia., M. Marková, M. Haluzík, J. Svobodová, M. Rosická, J. Nedvídková, T. Haas., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
20763. Serum leptin levels in septic men correlate well with C-reactive protein (CRP) and TNF-alpha but not with BMI
- Creator:
- Pavel Maruna, Robert Gürlich, Roman Fraško, and Martin Haluzík
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, záněty, leptin, inflammations, C reactive protein, tumor necrosis factor, 14, and 612
- Language:
- English
- Description:
- Leptin, an adipocyte-derived signaling factor, is a member of the IL-6 cytokine family. However there is no direct evidence of leptin stimulation of the acute phase protein (APP) synthesis which is typical for all other IL-6-like factors. The purpose of this study was to characterize the dynamics of circulating leptin in relation to ten APPs. We used postoperative septic patients as a model of cytokine network hyperstimulation and intensive APP reaction. The prospective study was performed on 22 patients with proven postoperative intraabdominal sepsis after large abdominal surgery. Plasma levels of leptin, TNF-a, IL-1ß, soluble IL-2 receptor (sIL-2R), IL-6 (ELISA analysis) and ten APPs (nephelometric analysis) were estimated. We have demonstrated a statistically significant elevation of plasma leptin concentrations in the septic group compared with healthy subjects (p<0.001). The correlation of plasma leptin and BMI during postoperative sepsis was diminished. The regression coefficient was the highest for leptin and CRP (r=0.48, p<0.05), and for leptin and alpha-1-antitrypsin (r=0.46, p<0.05) in the septic group. There was significant correlation between TNF-a and leptin (r=0.47, p<0.05) and between IL-6 and leptin (r=0.45, p<0.05) in septic patients. No significant correlation was found between leptin and "negative" APP and between leptin and IL-1ß. Leptin has thus been shown as an acute phase reactant with a potential hematopoietic, immunomodulatory and hepatocyte stimulating activity during the infectious and non-infectious stress response. The significant correlation between leptin and CRP and leptin and alpha-1-antitrypsin indicates that leptin can participate in APP synthesis regulation during a systemic inflammatory response., P. Maruna, R. Gürlich, R. Fraško, M. Haluzík., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
20764. Serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in women
- Creator:
- Kołodziejski, P. A, Pruszyńska-Oszmałek, E, Strowski, M. Z, Krauss, H, Nowak, K. W, Maćkowiak, P, Korek, E, Nogowski, L, Kaczmarek, P, Szczepankiewicz, D, and Sassek, M
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- fyziologie člověka, human physiology, Spexin, Kisspeptin, Obesity, Insulin resistance, 14, and 612
- Language:
- English
- Description:
- Spexin (SPX) and kisspeptin (KISS) are novel peptides relevant in the context of regulation of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum SPX and KISS levels in female non-obese volunteers (BMI<25 kg/m2) and obese patients (BMI>35 kg/m2). Correlations between SPX or KISS with BMI, McAuley index, QUICKI, HOMA IR, serum levels of insulin, glucagon, leptin, adiponectin, orexin-A, obestatin, ghrelin and GLP-1 were assessed. Obese patients had lower SPX and KISS levels as compared to non-obese volunteers (SPX: 4.48±0.19 ng/ml vs. 6.63±0.29 ng/ml; p<0.001, KISS: 1.357±0.15 nmol/l vs. 2.165±0.174 nmol/l; p<0.01). SPX negatively correlated with BMI, HOMA-IR, insulin, glucagon, active ghrelin and leptin. Positive correlations were found between SPX and QUICKI index, McAuley index, serum levels of obestatin, GLP-1 and adiponectin and orexin-A Serum KISS negatively correlated with BMI, HOMA-IR, serum levels of insulin, glucagon, active ghrelin and leptin. KISS positively correlated with QUICKI index, McAuley index and adiponectin. In summary, SPX and KISS show negative correlations with obesity, insulin resistance indices, and hormones known to affect insulin sensitivity in females. Both, SPX and KISS could be therefore relevant in the pathophysiology of obesity and insulin resistance., P. A. Kołodziejski, E. Pruszyńska-Oszmałek, E. Korek, M. Sassek, D. Szczepankiewicz, P. Kaczmarek, L. Nogowski, P. Maćkowiak, K. W. Nowak, H. Krauss, M. Z. Strowski., and Seznam literatury
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
20765. Serum lipid resistance to oxidation and uric acid levels in subjects with Down's syndrome
- Creator:
- Nagyová, A., Mária Šustrová, and Katarína Rašlová
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, Downův syndrom, kyselina močová, Down syndrome, uric acid, serum lipid resistance, 14, and 612
- Language:
- English
- Description:
- In subjects with Down¢ s syndrome (DS) increased oxidative stress and consequent oxidative cell damage have been reported. The aim of this study was to assess whether the excessive production of free oxygen radicals in these subjects can affect the copper-induced lipid oxidation resistance measured in fresh whole serum. Since a significant elevation of serum uric acid levels, which is an efficient hydrophilic antioxidant, has been repeatedly reported in subjects with DS, we studied the association between increased serum uric acid levels and lipid resistance to oxidation measured directly in serum samples by monitoring the change in absorbance at 234 nm. The group of subjects with Down¢ s syndrome consisted of 25 individuals (aged 18± 5 years). Control group included brothers and sisters of subjects with DS (n = 25, aged 17± 7 years). In subjects with DS, the serum lipid resistance to oxidation (lag time) was significantly higher than in controls (p< 0.05) and a concomitant increase in serum uric acid levels was observed (p< 0.001). A significant positive correlation between lag time and serum uric acid concentration was found in subjects with DS (r = 0.48, p< 0.05), while the positive correlation in the control group was not significant. The results suggest that increased serum uric acid levels repeatedly observed in subjects with DS may be associated with an enhanced resistance of serum lipids to oxidation which is thought to play an important role in the atherogenic process., A. Nagyová, M. Šustrová, K. Rašlová., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
20766. Serum omentin levels in adolescent girls with anorexia nervosa and obesity
- Creator:
- Oświęcimska, J., Suwała, A., Świętochowska, E., Ostrowska, Z., Gorczyca, P., Ziora-Jakutowicz, K., Machura, E., Szczepańska, M., Kukla, M., Stojewska, M., Ziora, D., and Ziora, K.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, mentální anorexie, obezita, poruchy příjmu potravy, dospívající dívky, inzulin, anorexia nervosa, obesity, eating disorders, adolescent girls, insulin, 14, and 612
- Language:
- English
- Description:
- It is believed that omentin is secreted by stromal cells of adipose tissue and modulates insulin se nsitivity. Data from a few studies have shown lower serum omentin in obese children and higher in anorexia nervosa. However, to date, there is lack of research on serum omentin concentrations in adolescent patients in a wide range of body mass index (BMI) and insulin resistance. In this cross -sectional study omentin -1 serum concentrations were evaluated using commercially available ELISA kit in 47 Polish girls with restrictive anorexia nervosa (AN), 50 with simple obesity (OB) and 39 healthy controls (C). T he mean serum omentin -1 concentration in girls with AN was statistically significantly higher than that of C and OB girls. Statistically significant (P<0.0001) negative correlations between the serum concentrations of omentin- 1 and body weight (r= - 0.73), BMI (r= - 0.75), standard deviation score for body mass index (BMI -SDS) (r= - 0.75), insulin (r= - 0.81) and HOMA -IR index (r= - 0.82) were seen in the entire examined population. We conclude, that omentin -1 is the nutritional marker reflecting body weight and insulin resistance. Our findings support the hypothesized role of omentin in maintenance of body weight and regulation of appetite and suggest the adaptation of its secretion to body weight and glucose metabolism., J. Oświęcimska, A. Suwała, E. Świętochowska, Z. Ostrowska, P. Gorczyca, K. Ziora-Jakutowicz, E. Machura, M. Szczepańska, M. Kukla, M. Stojewska, D. Ziora, K. Ziora., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
20767. Serum α-glutathione S-transferase as a sensitive marker of hepatocellular damage in patients with cystic fibrosis
- Creator:
- Kateřina Kotrčová, Veronika Skalická, Karel Kotaška, Markéta Pechová, Martin Chada, Jana Bartošová, Zdeněk Hříbal, Jiří Nevoral, Věra Vávrová, and Richard Průša
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, cystic fibrosis-related liver disease, liver tests, α¨-glutathione S-transferase, 14, and 612
- Language:
- English
- Description:
- The aim of the study was to evaluate serum α-glutathione S-transferase (s-GSTA) levels in patients with cystic fibrosis (CF) and to compare s-GSTA with other liver function tests and with a hepatic ultrasound scan (US). The cytosolic enzyme, a-glutathione S-transferase is predominantly found in the liver and is distributed uniformly in the liver tissue. In our study s-GSTA levels were measured in 37 CF patients aged 1 to 28 years (mean age 10.4 years, 24 males). The control group consisted of 27 patients aged 2 to 17 years (mean age 8.5 years, 18 males). The presence of hepatobiliary abnormalities was assessed by clinical examination, ultrasound scan, s-GSTA, and conventional liver enzymes: alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST) and g-glutamyl transferase (GMT). The calculated 5-95 % range of s-GSTA for the control group was 0.098-2.54 mg/l, for the CF group 0.43-9.76 mg/l. Mean s-GSTA level in the control group was 1.55 mg/l (S.D.=1.57), and 2.05 mg/l (S.D.=2.60) in the CF group. In the group of CF patients, the serum levels were significantly higher than in the control group (P<0.01). No significant correlation existed in the CF group between s-GSTA and conventional liver tests (ALT, AST, ALP and GMT). Four patients in the CF group had hepatobiliary abnormalities detectable by conventional liver tests, s-GSTA and US. Four patients had abnormal s-GSTA, while conventional liver tests and US were normal. One other patient had abnormal hepatic US, but normal standard liver tests and s-GSTA. The study has suggested that a raised s-GSTA level might be a marker of possible pathological changes of the hepatobiliar system in CF patients. Serum GSTA seems to be a more sensitive marker than transaminases for the monitoring of hepatocellular integrity and as an early predictor of hepatic damage., K. Šídlová, V. Skalická, K. Kotaška, M. Pechová, M. Chada, J. Bartošová , Z. Hříbal, J. Nevoral, V. Vávrová, R. Průša., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
20768. Šest století od bitvy u Nikopole
- Creator:
- Štěpánek, Petr
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- Czech
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
20769. Sestavení a pěstování směsek travných semen: s výsevní tabulkou
- Creator:
- Theodor z Weinzierlu and Bukovanský, Josef
- Publisher:
- C.k. ministerium orby
- Format:
- print, text, regular print, and 54 s. : il.
- Type:
- model:monograph and TEXT
- Subject:
- 633.2, 633, 24, travní směsi, semenářství, směsky jetelotravní, druhy, vlastnosti, trávy pícní, agrotechnika, výsev, tabulky, and Rostlinná výroba
- Language:
- Czech and German
- Description:
- sepsal Theodor rytíř z Weinzierlu, přeložil Josef Bukovanský and Converted from MODS 3.5 to DC version 1.8 (EE patch 2015/06/25)
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
20770. Sestavování krmných dávek při kontrole krmení
- Creator:
- Basil Macalík
- Publisher:
- Čes. hosp. společ. pro markr. Morav.
- Format:
- print and 19 s. : il. ; 8°
- Type:
- model:monograph and TEXT
- Subject:
- Živočišná výroba, krmná dávka, krmení, kontrola, 636, 24, and UL03
- Language:
- Czech
- Description:
- Předn. Basil Macalík
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public