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4182. Deep neck infections of odontogenic origin and their clinical significance. A retrospective study from Hradec Králové, Czech republic

Creator:
Doležalová, Helena, Zemek, Jaroslav, and Tuček, Luboš
Format:
print, text, and regular print
Type:
model:article, article, Text, časopisecké články, and TEXT
Subject:
mladiství, dospělí, staří, staří nad 80 let, celulitis--diagnóza--epidemiologie--mikrobiologie, dítě, předškolní dítě, ženské pohlaví, lidé, mužské pohlaví, lidé středního věku, krk, retrospektivní studie, sociálně ekonomické faktory, nemoci zubů--komplikace--mikrobiologie, and mladý dospělý
Language:
English
Description:
INTRODUCTION: Cellulitis remains a very serious disease even today. Mortality, which varied between 10-40%, has been reduced owing to the standard securing of airway patency and use of an appropriate surgical treatment approach. MATERIALS AND METHODS: A total of 195 patients were hospitalised for cellulitis at the University Hospital in Hradec Králové during 2007-2011. The following parameters were evaluated: age, gender, dependence of incidence of the disease on the season of the year, frequency of attacks of the particular areas and their clinical characteristics, aetiology of the inflammation, types of patient complaints, prevalence of current systemic diseases, results of microbiological and selected laboratory analyses, socio-economic status of the patients, and duration of patient stay at the hospital. Statistical analysis was performed by using Pearson's correlation coefficient, the statistical significance level was p < 0.05. RESULTS: The mean age of the patients was 39.8 years. The group of 195 patients included 108 (55%) males and 87 (45%) females. The mean time between the first symptoms of the disease and admission to the Department was 5 days. From among the 195 patients, 116 (59.5%) were working persons, 79 (40.5%) were non-working (children, students, unemployed persons, women on maternity leave, retired people). The odontogenic origin of the disease was verified in 173 (88.7%) patients. In total, 65 (33.3%) patients had no coinciding complicating systemic disease, 22 (11.3%) patients had diabetes mellitus. The most frequent symptom of cellulitis was painful swelling, found in 194 (99.5%) patients, followed by jaw contracture, found in 153 (78.5%) patients. CONCLUSION: The results are largely very similar to those of previous studies performed in other countries, except that we found no correlation between the prevalence of cellulitis and the socio-economic status, nor have we confirmed Klebsiella pneumoniae sp. as the cause of cellulitis in patients with diabetes mellitus. and H. Doležalová, J. Zemek, L. Tuček
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

4183. Defective Ca2+ handling proteins regulation during heart failure

Creator:
Hu, S.-T., Liu, G.-S., Shen, Y.-F., Wang, Y.-L., Tang, Y., and Yang, Y.-J.
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, srdeční selhání, heart failure, sarcoplasmic reticulum, ryanodine receptor, 14, and 612
Language:
English
Description:
Abnormal release of Ca2+ from sarcoplasmic reticulum (SR) via the cardiac ryanodine receptor (RyR2) may contribute to contractile dysfunction in heart failure (HF). We previously demonstrated that RyR2 macromol ecular complexes from HF rat were significantly more depleted of FK506 binding protein (FKBP12.6). Here we assess ed expression of key Ca2+ handling proteins and measured SR Ca2+ content in control and HF rat myocytes. Direct measurements of SR Ca2+ content in permeabilized cardiac myocytes demonstrated that SR luminal [Ca2+] is markedly lowered in HF (HF: Δ F / F 0 = 26.4±1.8, n =12; control: Δ F / F 0 = 49.2±2.9, n =10; P <0.01). Furthermore, we demonstrated that the expression of RyR2 associated proteins (including calmodulin, sorcin, calsequestrin, protein phosphatase 1, protein phosphatase 2A), Ca2+ ATPase (SERCA2a), PLB phosphorylation at Ser16 (PLB-S16), PLB phosphorylation at Thr17 (PLB-T17), L-type Ca 2+ channel (Cav1.2) and Na+-Ca 2+ exchanger (NCX) were significantl y reduced in rat HF. Our results suggest that systolic SR reduced Ca2+ release and diastolic SR Ca2+ leak (due to defective protein-protein interaction between RyR2 and its associated proteins) along with reduced SR Ca2+ uptake (due to down-regulation of SERCA2a, PLB-S16 and PLB- T17), abnormal Ca2+ extrusion (due to down-regulation of NCX) and defective Ca2+-induced Ca2+ release (due to down-regulation of Cav1.2) could co ntribute to HF., S.-T. Hu., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

4184. Deference to the administration in judicial review in the Czech Republic

Creator:
Zdeněk Kühn and Josef Staša
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
správní soudnictví, správní soudy, judicial review of administrative acts, administrative courts, judicial deference to the administration, corporate liability in public law, administrative sanctions, 16, and 34
Language:
English
Description:
Administrative courts at the onset of the new century face the challenge of ever-changing legislation. Frequent amendments do solvee some gaps but creat even more gaps which have to be filled by the courts. in the CZech Republic relative ease of judicial review by the courts of first instance and the wide open access to the Supreme Administrative Court mean that many administrative cases are resolved in four instances - two instances of administrative proceedings and additional two instances of judicial proceedings. All these things considered, it is not surprising that neither legal scholarship nor case law defines any general concept of judicial deference (or self-restraint) to the administration. Various areas of public law contain some expressions of judicial deference (most notably the limitation of judicial review of administrative discretion and subsidiarity of judicial review). Nevertheless, both case law and scholarship are far from subsuming these concepts under the common label of "judicial deference to the administration". This paper provides an in-depth analysis of the notion of judicial deference in the Czech Republic as well as some prospects in this field., Zdenek Kühn, Josef Staša., and Obsahuje bibliografické odkazy
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

4185. Deficit of coenzyme Q in heart and liver mitochondria of rats with streptozotocin-induced diabetes

Creator:
Jarmila Kucharská, Braunová, Z., Oľga Uličná, Zlatoš, L., and Anna Gvozdjáková
Format:
print, bez média, and svazek
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, diabetes mellitus, mitochondrie, oxidační stres, mitochondrias, oxidative stress, alpha-tocopherol, coenzyme Q, 14, and 612
Language:
English
Description:
Mitochondrial dysfunction and oxidative stress participate in the development of diabetic complications, however, the mechanisms of their origin are not entirely clear. Coenzyme Q has an important function in mitochondrial bioenergetics and is also a powerful antioxidant. Coenzyme Q (CoQ) regenerates alpha-tocopherol to its active form and prevents atherogenesis by protecting low-density lipoproteins against oxidation. The aim of this study was to ascertain whether the experimentally induced diabetes mellitus is associated with changes in the content of endogenous antioxidants (alpha-tocopherol, coenzymes Q9 and Q10) and in the intensity of lipoperoxidation. These biochemical parameters were investigated in the blood and in the isolated heart and liver mitochondria. Diabetes was induced in male Wistar rats by a single intravenous injection of streptozotocin (45 mg.kg-1), insulin was administered once a day for 8 weeks (6 U.kg-1). The concentrations of glucose, cholesterol, alpha-tocopherol and CoQ homologues in the blood of the diabetic rats were increased. The CoQ9/cholesterol ratio was reduced. In heart and liver mitochondria of the diabetic rats we found an increased concentration of alpha-tocopherol, however, the concentrations of CoQ9 and CoQ10 were decreased. The formation of malondialdehyde was enhanced in the plasma and heart mitochondria. The results have demonstrated that experimental diabetes is associated with increased lipoperoxidation, in spite of the increased blood concentrations of antioxidants alpha-tocopherol and CoQ. These changes may be associated with disturbances of lipid metabolism in diabetic rats. An important finding is that heart and liver mitochondria from the diabetic rats contain less CoQ9 and CoQ10 in comparison with the controls. We suppose that the deficit of coenzyme Q can participate in disturbances of mitochondrial energy metabolism of diabetic animals., J. Kucharská, Z. Braunová, O. Uličná, L. Zlatoš, A. Gvozdjáková., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

4186. Definice a měření optických frekvencí: Příležitost pro optické hodiny - a ještě něco

Creator:
Hall, John L. and Gregora, Ivan
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
optika, laserová technika, metrologie, optics, laser technology, metrology, 6, and 53
Language:
Czech
Description:
V letech 1999 a 2000 se setkaly a sloučily čtyři tradiční směry laserové technologie. Dva z nich byly zaměřeny na hledání stabilní opakovací frekvence stále kratších optických impulsů a na hledání co možná nejstabilnější neměnné optické frekvence. Sňatek ultrarychlých a ultrastabilních laserů zprostředkovaly převážně dva mezinárodní týmy, a k největšímu vzrušení došlo, když přišlo na svět mikrostrukturované optické vlákno zvláštní konstrukce, které bylo natolik nelineární, že bylo schopné produkovat "bílé světlo" z femtosekundových impulsů, takže výstupní spektrum obsáhlo celou optickou oktávu. Pak se poprvé podařilo realizovat interval optických frekvencí, který se rovnal nejnižší frekvenci hřebenu, a odpočítat tento interval jako násobek opakovací frekvence femtosekundového impulsního laseru. Takové, převodovku připomínající spojení mezi radiofrekvenčním standardem a jakýmkoli oprickým frekvenčním standardem, se objevilo, právě když dozrávaly ideje o zvyšování citlivosti. Čtyřčlenné spojení vedlo k explozi přesných měření frekvence a připravilo cestu pro rafinované testy některých našich draze opatrovaných fyzikálních principů, jako časové stability některých základních čísel ve fyzice (např. konstanty "jemné struktury", rychlosti světla, určitých poměrů atomových hmotností...), a ekvivalenci času měřeného hodinami založenými na různých fyzikálních jevech. Technologie stabilních laserů také umožňuje časově synchronizovat dva nezávislé femtosekundové lasery tak přesně, že se chovají, jako by zdrojem byl jediný laser. Zdokonalení experimentů s čerpacím a sondovacím svazkem přinese významnou aplikaci prostorového skenování biologických vzorků, které bude specifické pro konkrétní vazbu. Následující dekáda v optické fyzice by měla být ohromující., John L. Hall ; přeložil Ivan Gregora., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

4189. Deformation between African and Eurasian plate estimated from the European and the Egyptian GPS geodetic networks results from preliminary processing

Creator:
Antonín Zeman, Hassan, Khalil, Holešovský, Jan, Mohamed, Abdel Monem S., Novotný, Zbyněk, Salah, Mahmoud M., Jan Kostelecký, and Ali, Radwan M.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Geologie. Meteorologie. Klimatologie, GPS sítě, GPS netwoks, GPS coordinate time series, Egyptian GPS geodetic network, mechanics of continuum, deformation in the Eastern Mediterranean, 7, and 551
Language:
English
Description:
The article deals with estimating deformation between the African and the Eurasian Plate in the Eastern Mediterranean on the basis of GPS coordinate time series. Two sources of velocities were used for processing. The first was the freely available site velocities from the European Permanent Network (EPN). The second was the Egyptian GPS permanent network velocities. Their values were determined by the following technique. Firstly, the Egyptian site coordinates were computed from GPS daily observations, using the fiducial EPN stations. The daily site coordinates at a given time interval result in coordinate time series, which were analysed and used on velocity estimation of the Egyptian stations. Then the apparatus of the mechanics of continuum was applied to all resultant velocities. The regions of possible mutual interactions between the Eurasian and the African Plate in the Eastern Mediterranean were detected. The basic idea of this contribution is the common processing of GPS daily measurements from the Egyptian permanent network together with the EPN data. The available Egyptian GPS data cover almost the last three years, which represents a sufficient time interval for velocity estimation. Introducing the Egyptian permanent GPS measurements into processing enables a better estimate of deformations in the Eastern Mediterranean., Antonín Zeman, Khalil Hassan, Jan Holešovský, Abdel Monem S. Mohamed, Zbyněk Novotný, Mahmoud M. Salah, Jan Kostelecký and Radwan M. Ali., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

4190. Deformation trends in the Jezeří castle massif, Krušné hory Mts

Creator:
Blahoslav Košťák, Bohumil Chán, and Jan Rybář
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Geologie. Meteorologie. Klimatologie, těžba uhlí, coal mining, Krušné hory (Česko a Německo), Krušné hory Mountains (Czechia and Germany), rock slope stability, deformation monitoring, 7, and 551
Language:
English
Description:
Brown coal open pit mining in the basin under Krušné Hory Mts. came to contact with slopes of the mountains, and a problem of the stability in high and steep slopes in the crystalline rock became an important question. The question concerns Jezeří Castle built on the top of one of the hills in a most endangered section where even a supporting pillar in the sediments under the slope toe was left to support the slope. As a result, an extensive monitoring program regarding deformations was initiated in the region. The program involved several methods and some important results are discussed. The results that are displayed concern mainly measurements done in geophysical tiltmeter stations in two underground galleries driven into the two steep slope sections showing most dangerous situation, as well as extensometers located in the same locations. Long-term monitoring revealed a tectonic deformation process of a natural origin that is registered as slow and systematic tilts. Besides, it revealed several periods of anomalies that are of basic importance. During a long period of observation from 1982 till 2005 three important deformation anomalies were registered: the event of 1994, the event of 2002, and the event of 2003/2004. The first and the third event have been classified as of a large regional character that affected a wide mountainous area and could be interpreted as a tectonic impulse originating within the mountainous structure of the so called "Dome of Hora Svaté Kateřiny". The second event has been considered different, strictly connected with extreme precipitation of August 2002. The anomaly was evidenced even deep in the crystalline, so that it could not be seen as of a superficial character only. The movement which was registered at that time was oriented right into the pillar supporting the slope., It is concluded that it was a short manifestation of instability in the critical profile "Jezeří - pillar", which stresses the important stabilisation function of the supporting pillar without which the profile will be probably destabilised., Blahoslav Košťák, Bohumil Chán and Jan Rybář., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

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