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562. Afrobrazilské kulty v dílech Jorge Amada
- Creator:
- Havlíková, Marie
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- Czech
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
563. Afrobrazilské kulty v dílech Jorge Amada (II)
- Creator:
- Havlíková, Marie
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- Czech
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
564. Age and heat exposure-dependent changes in antioxidant enzymes activities in Rat's liver and brain mitochondria: role of α-tocopherol
- Creator:
- Stojkovski, V., Hadzi-Petrushev, N., Ilieski, V., Sopi, R., Gjorgoski, I., Mitrov, D., Jankulovski, N., and Mladenov, M.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, mitochondrie, játra, mozek, stárnutí, mitochondrias, liver, brain, aging, antioxidant enzymes, heat exposure, 14, and 612
- Language:
- English
- Description:
- V. Stojkovski ... [et al.]. and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
565. Age dependence of photosynthetic activity, chlorophyll fluorescence parameters and chloroplast ultrastructure in aurea and green forms of Nicotiana tabacum Su/su mutant
- Creator:
- Šiffel, P., Šantrůček, J., Lang, M., Braunová, Z., Šimková, M., Synková, H., and Lichtenthaler, H. K.
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- Multiple languages
- Description:
- The age dependence of the photosynthetic performance, chlorophyll fluorescence and chloroplast ultrastructure of green form and Chl ft-deficient form (aurea) of tobacco Su/su mutant were compared. The most pronounced differences between the aurea and green tobacco found in young leaves diminished with leaf age. Slower accumulation of the photosynthetic pigments during the development of aurea leaves was accompanied by a slower accumulation of LHC antennae of both photosystems, particularly that of PS2, and by retention of an increase in the capacity of PS2 photochemistry, measured as Fy/FM The ratio Fv/Fm, however, increased rapidly during maturation of aurea leaves, and fmally the mature aurea leaves exhibited higher values of this ratio than the green ones. Rates of photosynthesis at saturating irradiance (Epiax) saturating CO2 concentration (/’sat) decreased with leaf age for both aurea and green tobacco, being always higher in aurea leaves than in leaves of green tobacco of comparable age. AU these characteristics indicated retarded development of aurea leaves. Also the chloroplast ultrastructure, particularly grana formation, exhibited slower development. The decrease in /Wx and with leaf age in both tobacco forms and retardation in the development of aurea leaves can explain higher value of usually found in aurea tobacco.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
566. Age, genetic characteristics and number of cycles are critical factors to consider for successful protection of the murine heart with postconditioning
- Creator:
- Somers, S. J., Lacerda, L., Opie, L., and Lecour, S.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, ischemie, ischemia, reperfusion, postconditioning, 14, and 612
- Language:
- English
- Description:
- Postconditioning (PostC) is a re cently discovered phenomenon whereby brief repetitive cycles of ischaemia with intermittent reperfusion following prolonged is chaemia elicit cardioprotection. This study investigated whether the age, genetic characteristics or number of repetitive cycles influenced the protective effect of PostC in mice. C57BL/6 floxed or non-floxed STAT-3 mice aged between 14-16 weeks (young) or 18-20 weeks (older) were perfused on a Langendorff apparatus and subjected to 35 min global ischaemia and 45 min reperfusion. PostC was elicited by either 3 (PostC-3) or 6 cycles (PostC-6) of 10s ischaemia and 10 s reperfusion. PostC-3 and PostC-6 in both young and older non-floxed mice reduced the myocar dial infarct size. In contrast, only PostC-3 reduced myocardial infarct size in young floxed mice. Neither PostC-3 nor PostC-6 reduced the in farct in older floxed mice. Our data reveal that genetic characteristics, a minute difference in age or the nu mber of postconditioning cycles are critical factors to be consid ered for the successful effect of ischaemic postconditioning in a murine model. Moreover, these factors should be taken into consideration for future experimental research or clinical applications of this protective phenomenon., S. J. Somers ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
567. Age-associated endothelial dysfunction in rat mesenteric arteries: roles of calcium-activated K+ channels (Kca)
- Creator:
- Zhou, E., Qing, D., and Li, J.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, stárnutí, endoteliální dysfunkce, acetylcholin, aging, endothelial dysfunction, acetylcholine, potassium channels, mesenteric artery, 14, and 612
- Language:
- English
- Description:
- Age-associated changes in large blood vessels were characterized by increased arterial wall thickness, luminal dilation and impaired endothelial function. But little is known about the effect of age on structural and functional changes in small resistance arteries. The mechanisms underlying age-associated endothelial dysfunction in rat mesenteric resistance arteries were investigated in the present study. Small rat mesenteric arteries were excised and cannulated, and vascular endothelial functions were tested by acetylcholine (ACh). Our experiments showed (1) endotheliumdependent vasorelaxation induced by ACh was reduced in aged mesenteric arteries; (2) blockade of Kca channels markedly reduced the vasodilation in young and adult rats, the resultant reduction in aged rats was much smaller compared with young and adult rats; (3) inhibition of endothelial nitric oxide synthase (NOS) resulted in a significant reduction of vasodilation in young and adult, but there was a smaller reduction in aged rats. The results suggest that (1) endothelial function was impaired in mesenteric arteries of aged rats; (2) both Kca channels and nitric oxide (NO) contribute together to the ACh-induced vasorelaxation in small mesenteric arteries, and (3) both the impairment of Kca channel function and decreased NO account for the age-related endothelial dysfunction., E. Zhou, D. Qing, J. Li., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
568. Age-dependent effect of long-term microwave radiation on postnatal neurogenesis in rats: morphological and behavioral study
- Creator:
- Raček, A., Katarína Beňová, Arnoul, P., Závodská, M., Angelidis, A., Cigánková, V., Šimaiová, V., and Enikö Račeková
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- mikrovlnné záření, buněčná smrt, microwave radiation, cell death, adult neurogenesis, proliferation, rostral migratory stream, 14, and 612
- Language:
- English
- Description:
- Processes of adult neurogenesis can be influenced by environmental factors. Here, we investigated the effect of microwave radiation (MWR) on proliferation and cell dying in the rat rostral migratory stream (RMS) - a migration route for the neuroblasts of the subventricular zone. Adult and juvenile (two weeks old) rats were exposed to a pulsed-wave MWR at the frequency of 2.45 GHz for 1 or 3 h daily during 3 weeks. Adult rats were divided into two groups: without survival and with two weeks survival after irradiation. Juvenile rats survived till adulthood, when were tested in the light/dark test. Proliferating cells in the RMS were labeled by Ki-67; dying cells were visualized by Fluoro-Jade C histochemistry. In both groups of rats irradiated as adults we have observed significant decrease of the number of dividing cells within the RMS. Exposure of juvenile rats to MWR induced only slight decrease in proliferation, however, it strikingly affected cell death even two months following irradiation. In addition, these rats displayed locomotor hyperactivity and decreased risk assessment in adulthood. Our results suggest that the long-lasting influence of radiation is manifested by affected cell survival and changes in animals´ behavior., A. Raček, K. Beňová, P. Arnoul, M. Závodská, A. Angelidis, V. Cigánková, V. Šimaiová, E. Račeková., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
569. Age-dependent effect of oxidative stress on cardiac sarcoplasmic reticulum vesicles
- Creator:
- Eva Babušíková, Miloš Jeseňák, Dušan Dobrota, Narcisa Tribulová, and Peter Kaplán
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Experimentální medicína, kardiovaskulární fyziologie, oxidační stres, srdce, cardiovascular physiology, oxidative stress, heart, reactive oxygen species, protein damage, 14, and 616-092
- Language:
- English
- Description:
- The oxidative stress hypothesis of aging suggests that accumulation of oxidative damage is a key factor of the alterations in physiological function during aging. We studied age-related sensitivity to oxidative modifications of proteins and lipids of cardiac sarcoplasmic reticulum (SR) isolated from 6-, 15- and 26-month-old rats. Oxidative stress was generated in vitro by exposing SR vesicles to 0.1 mmol/l FeSO4/EDTA + 1 mmol/l H2O2 at 37 °C for 60 min. In all groups, oxidative stress was associated with decreased membrane surface hydrophobicity, as detected by 1-anilino-8-naphthalenesulfonate as a probe. Structural changes in SR membranes were accompanied by degradation of tryptophan and significant accumulation of protein dityrosines, protein conjugates with lipid peroxidation products, conjugated dienes and thiobarbituric acid reactive substances. The sensitivity to oxidative damage was most pronounced in SR of 26-month-old rat. Our results indicate that aging and oxidative stress are associated with accumulation of oxidatively damaged proteins and lipids and these changes could contribute to cardiovascular injury., E. Babušíková, M. Jeseňák, D. Dobrota, N. Tribulová, P. Kaplán., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
570. Age-dependent expression of 5alpha-reductase and androgen receptors mRNA by the canine prostate
- Creator:
- Shidaifat, F.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, prostata, králík, physiology, prostate, Oryctolagus, androgen receptors, 5α-reductase, 14, and 612
- Language:
- English
- Description:
- The growth of the prostate gland is androgen-dependent. Testosterone is converted to the most potent dihydrotestosterone (DHT) by 5α-reductase within the prostate. Androgen interacts with androgen receptors (AR) to regulate normal growth of the prostate and has also been implicated in both the progression of benign prostate hyperplasia and prostate cancer. This study was conducted to compare the mRNA expression of AR and 5α-reductase by the prostate gland from three age categories: immature, young-mature and old dogs. Quantitative gene expression was assessed by the real-time PCR and the results were expressed as a relative mRNA expression of the target gene. This study revealed that there was no significant difference in the mRNA expression of the AR gene by the prostate gland of immature, young and old dogs. In contrast, there is a highly significant (P<0.001) down-regulation in 5α-reductase gene by the prostate of young and old dogs as compared with immature dogs. However, there is no significant difference in mRNA expression of the 5α-reductase gene by the prostate gland from young and old dogs. This differential expression of AR and 5α-reductase genes, which are involved in the regulation of androgen effect on prostate gland, might reflect an age-dependent growth requirement of the gland for androgens., F. Shidaifat., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public