Precipitation is important input into the hydrological system. With its time and space distribution significantly influences outflow from the catchment. This contribution deals with movement of rainfall events in Prague area. Velocities and directions of storm movement have been estimated on the basis of two years measurement from PVS a.s. rain-gauge network. Mostly convective rainfall events have been evaluated. There are estimated mean parameters for whole area and partial values of rainfall movement for nine subareas, into which the Prague area has been divided. Results can be used for estimation of space-time rainfall distribution in the catchment. and Srážka je důležitou vstupní veličinou hydrologického systému. Svým časovým a plošným rozdělením výrazně ovlivňuje odtok z povodí. Předkládaný příspěvek se zabývá pohybem dešťů na území Prahy. Na základě dvouletých měření srážkoměrné sítě PVS a.s. byly stanoveny rychlosti posunu a směry pohybu převážně konvektivních dešťových událostí v zájmové oblasti. Jsou stanoveny průměrné parametry pohybu pro celou oblast a dílčí hodnoty rychlostí a směrů pohybu srážky v devíti podoblastech, na které bylo území Prahy rozděleno. Výsledné hodnoty pohybu srážek lze využít pro stanovení časoprostorového průběhu srážky v povodí.
The Moravia territory has been the subject of geokinematic investigation within scope of several realized research projects and repeated GPS campaigns since 1992. The monitoring has been concentrated on all the Moravia region as well as on particular areas of interest concerning the eventual possible geodynamic changes (Králický Sněžník Massif, Diendorf-Čebín Tectonic Zone (DCTZ) and others). At present time all the territory is covered by several tenths of permanent and epoch GNSS stations. Long observation time series at permanent stations alone are not sufficient for delivering the regional velocity field of sufficient density. On the other hand, epoch stations are more densely spread but periods of repeated observations are less frequent and often the data processing is not homogeneous. In the paper the preliminary kinematic model is briefly described which gives for the first time the general view of movement tendencies at the region of Moravia. On base of long-term monitoring it shows that the Southern Moravia region is more active then it was supposed., Lubomil Pospíšil, Otakar Švábenský and Josef Weigel., and Obsahuje bibliografii
Moxidectin is a macrocyclic lactone belonging to milbemycin family closely related to ivermectin and is currently progressing towards Phase III clinical trial against human infection with the filaria Onchocerca volvulus (Leuckart, 1894). There is a single report on the microfilaricidal and embryostatic activity of moxidectin in case of the human lymphatic filarial parasite Brugia malayi (Brug, 1927) in Mastomys coucha (Smith) but without any adulticidal action. In the present study, the in vitro and in vivo antifilarial efficacy of moxidectin was evaluated on, B. malayi. In vitro moxidectin showed 100% reduction in adult female worm motility at 0.6 µM concentration within 7 days with 68% inhibition in the reduction of MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide dye) (which is used to detect viability of worms). A 50% inhibitory concentration (IC50) of moxidectin for adult female parasite was 0.242 µM, for male worm 0.186 µM and for microfilaria IC50 was 0.813 µM. In adult B. malayi-transplanted primary screening model (Meriones unguiculatus Milne-Edwards), moxidectin at a single optimal dose of 20 mg/kg by oral and subcutaneous route was found effective on both adult parasites and microfilariae. In secondary screening (M. coucha, subcutaneously inoculated with infective larvae), moxidectin at the same dose by subcutaneous route brought about death of 49% of adult worms besides causing sterilisation in 54% of the recovered live female worms. The treated animals exhibited a continuous and sustained reduction in peripheral blood microfilaraemia throughout the observation period of 90 days. The mechanism of action of moxidectin is suggested to be similar to avermectins. The in silico studies were also designed to explore the interaction of moxidectin with glutamate-gated chloride channels of B. malayi. The docking results revealed a close interaction of moxidectin with various GluCl ligand sites of B. malayi.
The study is the first attempt to map putting on stage of Mozart’s operas and singspiels in Bohemia from the late 1780s till 1900 outside Prague. It focuses on theatre troupes that included Mozart’s pieces in their repertory, on their directors and singers, as well as the places, where they performed. The information is drawn from such sources as archival official documents, collections of theatre posters in archive and museum collections, notes in contemporary press, contemporary theatre almanach, etc. As much as 106 performances of Mozart’s scenical pieces were found, of which the most frequent were Don Giovanni (35¥), Die Zauberflöte (32¥) and Le nozze di Figaro (25¥). With regard to the fact that the article was written within a larger research looking closely at theatre activity in the Bohemian regions in the nineteenth century, the author is convinced that the list of locations, where professional execution of Mozart’s opera could have taken place, is complete. Less guaranteed (especially in the period until the mid-nineteenth century) is the completeness of the titles performed, and their rendering – there could have been more of these.
Moderní neurovědy zatím nedokážou zodpovědět „velké“ otázky –
třeba jak přesně vznikají myšlenky nebo emoce. Každým dnem se
ale o nejsložitějším lidském orgánu objevují nové vědecké studie
a většina míří nejen k pochopení dílčích procesů v mozku, ale
i k budoucí léčbě jeho nemocí či poruch.
Přesné informace o počátečních fázích vzniku a vývoje sluneční soustavy nelze získat zpětnou integrací pohybových rovnic, neboť se z dlouhodobého hlediska jedná o ljapunovský nestabilní systém, jehož časový vývoj je na počáteční podmínky extrémně citlivý. Pro modelování primordiálních fází planetárního systému je proto zapotřebí provést několik sad simulací jeho vývoje s různými hodnotami počátečních parametrů a na výsledná data nahlížet statisticky. Pro modelování vývoje sluneční soustavy lze využít symplektických integrátorů, tj. numerických schémat, která aproximují hamiltonovský systém při zachování jeho symplekticity., Jakub Rozehnal., and Obsahuje seznam literatury
The contribution refers on the accelerating of the process method of stress analysis using PhotoStressσ software applications PhotoStress. PhotoStress application was developed for the analysis of the direction and size of the main strain respectively the analysis of the main normal stresses on the loaded photoelastic coated structural elements on the authors workplace. It accelerates the process of measurement and evaluation of major strains and principal stresses at a point on the line or a curve respectively. It allows in these entities determining the direction and size differences and separated values of major strain or the stresses on the basic of the photo of loaded photoelastic coated objects. In the paper is describing the application PhotoStress and the view of the separation of the main normal stresses at using the method of oblique incidence photoelastic coated steel ring and also a comparison of results obtained PhotoStress software application and numerical solution, by the finite element method. and Príspevok poukazuje na urýchlenie procesu analýzy napätosti metódou PhotoStress® pri využití softvérovej aplikácie PhotoStress. Aplikácia PhotoStress bola vyvinutá pre analýzu smerov a veľkosti hlavných pomerných deformácií, resp. hlavných normálových napätí na zaťažených fotoelasticky povrstvených konštrukčných prvkoch na pracovisku autorov. Urýchľuje proces merania a vyhodnotenia hlavných deformácií, resp. hlavných napätí v bode, po úsečke, prípadne po krivke. V týchto entitách umožňuje určenie smerov a veľkosti rozdielov a separovaných hodnôt hlavných deformácií, resp. napätí na základe fotografie zaťažených fotoelasticky povrstvených objektov. V príspevku je uvedený popis aplikácie PhotoStress s ukážkou separácie hlavných normálových napätí pri využití metódy šikmého osvetlenia na fotoelasticky povrstvenom oceľovom prstenci a tiež komparácia výsledkov získaných softvérovou aplikáciou PhotoStress a numerickým riešením, metódou MKP.