V sídle Stálého zastoupení České republiky při EU se 28. května 2015 uskutečnila akce k příležitosti desetiletého výročí působení České styčné kanceláře pro výzkum, vývoj a inovace v Bruselu. Setkání doprovodila výstava předmětů z Pevnosti poznání, interaktivního muzea vědy Univerzity Palackého v Olomouci. and Kateřina Slavíková.
Nedílnou součást meteorologického a klimatologického výzkumu představují pozorování a měření stavu atmosféry. Příroda je jedna velká laboratoř, v níž se neustále dějí experimenty - ale zatímco lze ve standardních laboratořích experimenty připravovat a opakovat, příroda nic neopakuje a nezměřená data již nelze znovu získat. and Zbyněk Sokol.
Our own study as well as others have previously reported that hypoxia activates 15-lipoxygenase (15-LO) in the brain, causing a series of chain reactions, which exacerbates ischemic stroke. 15-hydroxyeicosatetraenoic acid (15-HETE) and 15-oxoeicosatetraenoic acid (15-oxo-ETE/15-KETE) are 15-LO-specific metabolites of arachidonic acid (AA). 15-HETE was found to be rapidly converted into 15-oxo-ETE by 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in some circumstances. We have demonstrated that 15-HETE promotes cerebral vasoconstriction during hypoxia. However, the effect of 15-oxo-ETE upon the contraction of cerebral vasculature remains unclear. To investigate this effect and to clarify the underlying mechanism, we performed immunohistochemistry and Western blot to test the expression of 15-PGDH in rat cerebral tissue, examined internal carotid artery (ICA) tension in isolated rat ICA rings. Western blot and reverse transcription polymerase chain reaction (RT-PCR) were used to analyze the expression of voltage-gated potassium (Kv) channels (Kv2.1, Kv1.5, and Kv1.1) in cultured cerebral arterial smooth muscle cells (CASMCs). The results showed that the levels of 15-PGDH expression were drastically elevated in the cerebral of rats with hypoxia, and 15-oxo-ETE enhanced ICA contraction in a dose-dependent manner. This effect was more significant in the hypoxic rats than in the normoxic rats. We also found that 15-oxo-ETE significantly attenuated the expression of Kv2.1 and Kv1.5, but not Kv1.1. In conclusion, these results suggest that 15-oxo-ETE leads to the contraction of the ICA, especially under hypoxic conditions and that specific Kv channels may play an important role in 15-oxo- ETE-induced ICA constriction., Di Wang, Yu Liu, Ping Lu, Daling Zhu, Yulan Zhu., and Obsahuje bibliografii
The Velvet Revolution was a non-violent uprising in Czechoslovakia that saw the overthrow of the Communist government. On November 17, 1989, police suppressed a peaceful student demonstration in Prague. Among the protesters were many young employees of Czechoslovak Academy of Sciences. Based on the November events, civil forums were created at worksplaces. In consequences of the political evolvement, some of the compromised directors from institutes left their positions and during the following six months all directors had to be evaluated. Scientific committies began to form. On November 6, 1989, the entire presidium of ČSAV resigned and December 12, the Chamber of elected representatives of ČSAV was established. This organ became a carrier of fundamental changes, for example the first Czech science foundation was set up and proposals for evaluation of the institutes formed. The new organization structures of Academy were created. and Antonín Kostlán.