Bohuslav Lázňovský, Výkladový slovníček na stranách 190-203, Poznámky pod čarou, Obsahuje bibliografické odkazy, and Converted from MODS to DC version 1.8 (EE patch 2018/05/24)
Primary graft dysfunction (PGD) is a life-threatening complication among heart transplant recipients and a major cause of early mortality. Although the pathogenesis of PGD is still unclear, ischemia/reperfusion injury has been identified as a predominant factor. Both necrosis and apoptosis contribute to the loss of cardiomyocytes during ischemia/reperfusion injury, and this loss of cells can ultimately lead to PGD. The aim of our prospective study was to find out whether cell death, necrosis and apoptosis markers present in the donor myocardium can predict PGD. The prospective study involved 64 consecutive patients who underwent orthotopic heart transplantation at our institute between September 2010 and January 2013. High-sensitive cardiac troponin T (hs-cTnT) as a marker of minor myocardial necrosis was detected from arterial blood samples before the donor’s pericardium was opened. Apoptosis (caspase-3, active + pro-caspase-3, bcl-2, TUNEL) was assessed from bioptic samples taken from the right ventricle prior graft harvesting. In our study, 14 % of transplant recipients developed PGD classified according to the standardized definition proposed by the ISHLT Working Group. We did not find differences between the groups in regard to hs-cTnT serum levels. The mean hs-cTnT value for the PGD group was 57.4±22.9 ng/l, compared to 68.4±10.8 ng/l in the group without PGD. The presence and severity of apoptosis in grafted hearts did not differ between grafts without PGD and hearts that subsequently developed PGD. In conclusion, our findings did not demonstrate any association between measured myocardial cell death, necrosis or apoptosis markers in donor myocardium and PGD in allograft recipients. More detailed investigations of cell death signaling pathways in transplanted hearts are required., O. Szarszoi, J. Besik, M. Smetana, J. Maly, M. Urban, J. Maluskova, A. Lodererova, L. Hoskova, Z. Tucanova, J. Pirk, I. Netuka., and Obsahuje bibliografii
The safety of pedestrians and cyclists in traffic is justified especially in terms of prevention. This paper deals with the biomechanical analysis of load exerted on the child pedestrian and cyclist. In the case of cyclists, the impact configurations were chosen with respect to the statistical outputs (sudden enter the road or the case of non-giving way; the car front vs. the left side of the cyclists). Two tests were performed in the same configuration and nominal collision speed, the first one with a bicycle helmet and the second one without the helmet. The initial position of pedestrian was chosen with respect to the dummy degrees of freedom. Using the accelerometers in the head, chest, pelvis and knee of the dummy acceleration fields were detected, which are the child pedestrian and cyclist exposed during the primary and secondary collision. In addition, prediction diagnostics method implementation was discussed such as one possible solution of vulnerable road users harm reduction. In conclusion, the results are interpreted by values of biomechanical load and severity of potential injuries including kinematic and dynamic comparison.
Biometric data are typically used for the purposes of unique identification of a person. However, recent research suggests that biometric data gathered for the purpose of identification can be analysed for extraction of additional information. This augments indicative value of biometric data. This paper illustrates the range of augmented indicative values of the data as well as identifies crucial factors that contribute to increased vulnerability of data subjects., Alžběta Krausová, Hananel Hazan, Ján Matejka., and Obsahuje bibliografické odkazy
Projekt Centra kompetence BIORAF se již třetím rokem zabývá biorafinačními procesy, které se zakládají na chemické, biologické a termické přeměně přírodních materiálů z odpadů rostlinného a živočišného původu ze zemědělské výroby i potravinářského průmyslu či z řas na žádané produkty s vysokou přidanou hodnotou. Projekt se řeší s finanční podporou Technologické agentury ČR za koordinace Ústavu chemických procesů AV ČR a ve spolupráci s Vysokou školou chemicko-technologickou, Botanickým ústavem AV ČR a společnostmi Agra, Rabbit, Briklis a Ecofuel. Viz také První rok Centra BIORAF a Aplikace biorafinací. and Olga Šolcová.
The Academy of Sciences of the Czech Republic (AS CR) established a new public research institution, the Institute of Biotechnology AS CR, v. v. i. The primary ambition of this new institute is to develop cutting-edge basic and oriented research on topics opening for diagnostic and therapeutic applicatons in human medicine. In particular, the institute was established to serve as a nucleation center of BIOCEV, the joined Biotech & Biomed Research Center of the Academy of Sciences with Charles University, to be built at Vestec near Prague by the year 2012 with the support of the European Regional Development Funds in frame of the Operational Program R&D for Innovation., Peter Šebo, -red-., and Tři otázky pro ředitele připravila -red-
The present paper introduces a group of transformations on the collection of all bivariate copulas. This group contains an involution which is particularly useful since it provides (1) a criterion under which a given symmetric copula can be transformed into an asymmetric one and (2) a condition under which for a given copula the value of every measure of concordance is equal to zero. The group also contains a subgroup which is of particular interest since its four elements preserve symmetry, the order between two copulas and the value of every measure of concordance.