In 2018, during a rescue archaeological excavation taking place in one of the gardens of Staré Město near Uherské Hradiště, 23 early medieval graves containing skeletal remains of 26 individuals were detected. The site is situated on the northern border of the well-known Great Moravian burial ground ‘Na Valách’. In a large number of the newly excavated graves, greater or lesser deviations from the usual funeral rite were recorded. While the established burial rite in Great Moravian society means the deceased lies on their back in the supine position with extended extremities and head towards the west, here we found skeletons in very different orientations, lying in a prone or crouched position, or, at least, with unusual positions of their upper or lower limbs. Additionally, some of the graves contained incomplete or no skeletons. There is also one double burial and a triple burial, and several graves in superpositions. In nine graves, objects of material culture were found, the most important of them come from the rider’s grave 20/2018. The presented study aims to interpret the burial contexts using the bioarchaeological approach, which is, however, affected by the quality of the preserved finds, especially skeletal remains.
Nedávno jsme v tomto časopise (JMO 4/2009) v článku nazvaném''Před pořízením systému vojáka pro AČR'', popsali náš názor na projekt tzv. systému vojáka, v AČR tehdy pojmenovaný jako ''Voják 21.století''. Nyní je tento projekt veden v Armádě České republiky (AČR) pod názvem modulární bojový komplet (MBK). I náš pohled doznal za uplynulé dva roky určitého posunu, který se odrazil i v návrhu řešení, jež označujeme zkratkou BIG-OŠ, tedy Battlefield Integrated Groups - organizace a školení. Kombinací anglického a českého názvu chceme vyjádřit jak naše národní specifikace a požadavky, tak i skutečnost, že je tento systém připraven na použití v rámci vojenských struktur NATO. Tomuto přístupu odpovídá i systémové složení kompletu, jež vhodně kombinuje národní a alianční prvky a technologie. Tento přístup zde chceme stručně představit. and Recently we described in the JMO journal article, called ''Before acquisition of the soldier system for the Czech Army'', our estimation of so-called the soldier system project, in the Czech Army known like ''Soldier 21st century''. Nowadays, this project is registered under the designation Modular Combat Set (MBK) in the Czech Army. Our view has reached certain shift for last two years and that reflected the proposal of solution, which we have marked like BIG-OŠ - Battlefield Integrated Groups - the organization and training. By the combination English and Czech appellation we want to expresses both our national specification and requirements and the fact that this system is ready for use within the scope of the NATO military configuration. The attitude corresponds to the systematic structure of the set, which combines appropriately not only the national and alliance factors but also the technologies. We would like to introduce the above mentioned attitude briefly in the following text.
One of the most abundant immunologic cell types in early decidua is the uterine natural killer (UNK) cell that despite the presence of cytoplasmic granules rich in perforin and granzymes does not degranulate in normal pregnancy. UNK cells are important producers of angiogenic factors that permit normal dilation of uterine arteries to provide increased blood flow for the growing feto-placental unit. Gram-negative bacteria lipopolysaccharide (LPS) administration can trigger an imbalance of pro-inflammatory and anti-inflammatory cytokines impairing the normal immune cells activity as well as uterine homeostasis. The present study aimed to evaluate by immunohistochemistry the reactivity of perforin and α-actin on UNK cell from LPStreated pregnant mice. For the first time, we demonstrate that LPS injection in pregnant mice causes α-actin down regulation, concomitantly with perforin loss in UNK cells. This suggests that LPS alters UNK cell migration and activates cytotoxic granule release., B. Zavan, A. M. do Amarante-Paffaro, V. A. Paffaro Jr., and Obsahuje bibliografii
The concept of α-ideals in posets is introduced. Several properties of α-ideals in 0-distributive posets are studied. Characterization of prime ideals to be α-ideals in 0- distributive posets is obtained in terms of minimality of ideals. Further, it is proved that if a prime ideal I of a 0-distributive poset is non-dense, then I is an α-ideal. Moreover, it is shown that the set of all α-ideals α Id(P) of a poset P with 0 forms a complete lattice. A result analogous to separation theorem for finite 0-distributive posets is obtained with respect to prime α-ideals. Some counterexamples are also given.
In vitro produced β-like cells can provide promising cell therapy for curing the epidemic of diabetes. In this context, we aimed to investigate the effects of different concentrations of γ-aminobutyric acid (GABA) on the differentiation of rat pancreatic ductal epithelial-like stem cells (PDESCs) into β-like cells. The PDESC line cells were cultured in the basal media (DMEM/F12 + 10% FBS + 1% penicillinstreptomycin) supplemented with 0 µM, 5 µM, 50 µM, 500 µM, and 5 mM of GABA for 28 days to induce their differentiation. The differentiated cells were detected by cell morphology, dithizone (DTZ) staining, immunofluorescence staining, real-time polymerase chain reaction (qPCR), and glucose-stimulated insulin secretion (GSIS) assay to validate their identity. At the end of 28 days, compared with the control group, enrichment of induced cells was high among the 5 μM, 50 μM, 500 μM, and 5 mM GABA induction groups. The formation of islet-like cell clusters (ICCs) began at 14 days, and the cell clusters showed a growth trend with the culture time. The induced ICCs were positive for DTZ staining, while the control group showed negative results for DTZ staining and the differentiated cells were also positive for β-cell-specific markers (Ins1 and Pdx1). GSIS assay of 50 μM induction group cells at 28 days showed significantly higher levels of C-peptide and insulin secretion than the control, 5 μM, 500 μM, and 5 mM GABA-treated groups (P < 0.01). At the same time, the 50 μM induction group cells also showed significantly higher levels of Ins1, Pdx1 and Nkx6.1 mRNA as compared to the 5 μM, 500 μM and 5 mM GABA groups (P < 0.01). Thus, the addition of GABA to the basal medium effectively induced differentiation of adult rat PDESCs into insulin-secreting β-like cells, and 50 μM was the most effective concentration for the induction.
According to a widespread view, deontic modalities are relative to normative systems. Four arguments in favour of this suggestion will be presented in this paper. Nevertheless, I have proposed and defended an analysis of deontic modalities in terms of Transparent Intensional Logic (TIL) that is non-relativistic (with respect to normative systems) and accommodates minimal semantics of TIL. This leads to a question whether one can do justice to arguments for deontic relativism and put forward a relativistic analysis of deontic modalities in TIL. The main aim of this paper is to amend the former analysis of deontic modalities in terms of TIL to incorporate both the standard (relativistic) view and the minimal semantics of TIL., Podle široce rozšířeného pohledu jsou deontické modality vztaženy k normativním systémům. V tomto příspěvku budou prezentovány čtyři argumenty ve prospěch tohoto návrhu. Nicméně jsem navrhl a obhájil analýzu deontických modalit v podmínkách transparentní intenzivní logiky (TIL), která je nerelativistická (s ohledem na normativní systémy) a pojme minimální sémantiku TIL. Toto vede k otázce zda jeden může dělat spravedlnost k argumentům pro deontic relativismus a navrhl relativistic analýzu deontic modalities v TIL. Hlavním cílem této práce je doplnit dřívější analýzu deontických modalit z hlediska TIL tak, aby zahrnovala jak standardní (relativistický) pohled, tak minimální sémantiku TIL., and Daniela Glavaničová