Uterus transplantation (UTx) is a promising treatment option for women who wish to give birth but suffer from absolute uterine factor infertility. This paper presents an interim analysis of a trial focusing on the causes, prevention, diagnosis, and management of graft thrombosis. Our team analyzed 10 cases of UTx (recipients numbered 1 to 10). Early thrombosis developed in 2 of 10 (20 %) recipients, and thrombectomy and temporary viability preservation were achieved in both cases. However, re-thrombosis developed in both cases, and a graft hysterectomy was carried out. In recipient number 2, vascular changes might have contributed to graft thrombosis. The histopathological finding of the explant revealed subintimal excentric fibrosis with focal sclerotic changes. In recipient number 8, thrombosis was facilitated by external compression of the vascular pedicles by the hematoma as well as production of de novo donor-specific antibodies. Thrombosis led to graft loss in both cases despite an attempt at a thrombectomy. Therefore, the focus must be on the prevention including a thorough evaluation of the donor candidate. In the postoperative course, perfusion is closely followed-up with an ultrasound, Doppler flow monitoring, and macroscopic evaluation of the cervix. In the case that findings are unclear, a relaparotomy should be promptly indicated. If thrombosis is revealed, a thrombectomy and an attempt to salvage of the graft are indicated; however, the role of this strategy is questionable due to the low chance of long-term success. The indication of upfront graft removal and early retransplantation in the treatment of uterine graft remains debatable.
The long water-tube tiltmeter observations of the plumb line variations were begun about four years ago. Since 2001, twice, the instrument registered strong plumb line variations associated with earthquake. Earthquake in September 2003 made opportunity for verification of hydrodynamic system of tiltmeter. We obtained in observations large number of cycle-slip effects, which made impossible correct interpretation of data during main phase of phenomenon. Results of tests of dumping system of water waving helped us to introduce some improvements in hydrodynamic system of instrument. Catastrophic earthquake with magnitude 9.1 which took place in the area of Indian Ocean on 26th December 2004 generated phenomenon of the Earth free oscillations associated with anomalous plumb line variations of the order of single milliseconds of arc (mas). The effects of surface waves passing associated with Earth free oscillations were registered by the tiltmeter as series of anomalous plumb line variations. Surface waves produced several milliseconds of arc amplitude of plumb line variations. Results of observations showed that low-pass filters considerably reduce contribution of short-period effects and effectively protect hydrodynamic system of instrument against resonance. Nevertheless during first two hours of phenomenon cycle-slip effects occurred several times. Plot of plumb line variations in space from 26th December 2004 showed us large complication of tilt signals as well as dominated role of tidal signal. Spectral analysis of the time series of the plumb line variations obtained with help of the long water-tube tiltmeter on 26 December 2004 appeared existing fundamental modes (n = 0) in the Earth free oscillations didn’t exceed 0.2 mas., Marek Kaczorowski., and Obsahuje bibliografii
The orientation of the Earth in space is measured by space geodetic techniques. Each technique has its weaknesses so the best way how to get a representative solution of Earth orientation parameters is to combine all of them together using some appropriate method. There are basically two approaches, the rigorous and non-rigorous one. The method used in this paper belongs to the second category. Since 1999, when the authors Kostelecký and Pešek put basis of the combination method, the method has been modified and improved. The particular improvements are described hereafter and recent results are presented. These results of collocation station velocities are compared with the velocities published by ITRF 2005 and NUVEL-1A. The mean values of differences are 2.7 mm/y and 5.9 mm/y, respectively., Vojtěch Štefka, Ivan Pešek, Jan Vondrák and Jan Kostelecký., and Obsahuje bibliografii
Recently we derived a new star catalog EOC-4 that contains not only the mean positions and linear proper motions, but also periodic changes, due to orbital motions, for double and multiple star systems. The catalog contains 4418 stars that were observed in programs monitoring Earth orientation by optical astrometry during the 20th century. 599 stars of the catalog have significant periodic components. This catalog is now used, as a basic celestial frame, to obtain the Earth orientation parameters from optical astrometric observations of latitude/universal time/altitude in the interval 1899.7-1992.0. Polar motion is determined in 5-day steps for the whole interval studied, Universal time covers the interval 1956.0-1992.0 (i.e., after the invention of atomic clocks) also in 5-day steps, and celestial pole offsets (with respect to recent IAU2000 and IAU2006 models of nutation and precession) are modeled by second-order polynomials of time. In addition to these, a combination of Love and Shida numbers for each observing site is computed., Jan Vondrák, Cyril Ron and Vojtěch Štefka., and Obsahuje bibliografii
Commercial chambers for in vivo gas exchange are usually designed to measure on vascular plants, but not on cryptogams and other organisms forming biological soil crusts (BSCs). We have therefore designed two versions of a chamber with different volumes for determining CO2 exchange with a portable photosynthesis system, for three main purposes: (1) to measure in situ CO2 exchange on soils covered by BSCs with minimal physical and microenvironmental disturbance; (2) to acquire CO2-exchange measurements comparable with the most widely employed systems and methodologies; and (3) to monitor CO2 exchange over time. Different configurations were tested in the two versions of the chamber and fluxes were compared to those measured by four reference commercial chambers: three attached to two respirometers, and a conifer chamber attached to a portable photosynthesis system. Most comparisons were done on biologically crusted soil samples. When using devices in a closed system, fluxes were higher and the relationships to the reference chambers were weaker. Nevertheless, high correlations between our chamber operating in open system and measurements of commercial respiration and photosynthetic chambers were found in all cases (R2 > 0.9), indicating the suitability of the chamber designed for in situ measurements of CO2 gas exchange on BSCs., M. Ladrón De Guevara, R. Lázaro, J. L. Quero, S. Chamizo, F. Domingo., and Obsahuje bibliografii
Reduced physical activity and abundant energy intake are two most common factors leading to uncontrolled body weight gain. But these factors are not under entire internal consciousness control; they are also partially genetically determined and are affected by for example food marketing practices. In addition to these two widely accepted factors, there are some other factors, whose could also contribute to the recent increase of obesity prevalence. For example, non-exercise activity thermogenesis, sleeping habits, more stable inside room temperatures (using of heating and air conditioning), high prescription of medications with weight gain as side effect, psychosocial factors, unfavourable socioeconomic status and unpleasant urban environment are the background factors which should not be omitted if obesity/BMI determination should be fully understood and kept under control. In conclusion, unhealthy life style is necessary, but not sufficient for obesity development., J. A. Hubáček., and Obsahuje seznam literatury
a1_Diabetes mellitus is a risk factor of cardiovascular diseases. ECG of patients with diabetes mellitus type 1 (DM 1) shows tachycardia (block of parasympathetic innervation) and abnormal repolarization (increased QT interval and QT dispersion (QTd)) indicating a risk of ventricular tachycardia and sudden death in young people with DM 1. The aim of the present report was to measure 145 parameters of the heart electric field in 22 patients (14 men, 8 women) with DM 1 without complications (mean age 32.8±11.4 years) and in 22 controls (11 men, 11 women, mean age 30.1±3.4 years). The duration of diabetes was 13.9 ±7.8 years. The parameters were regist ered by the diagnostic system Cardiag 112.2 and statistically evaluated by the Student and Mann-Whitney test. Tachycardia (86.3±2.7 beats.min-1), shortening of both QRS (79.9±1.6 ms) and QT (349.0±5.9 ms) and increased QT dispersion (115±36 ms) were observed in DM 1 when compared with the controls (75.0±2.1 beats. min -1, QRS 89.9±2.7 ms, QT 374.0±4.4 ms, QTd 34.0±12.0 ms, p<0.01). The QTc was 415.2±4.1 ms in DM 1 and 401.4±6.6 ms in controls (NS)., a2_Other significant findings in DM 1 were: higher maximum of depolarization isopotential maps (DIPMmax) in the initial phase of QRS and less positive in the terminal phase, more negative minimum (DIPMmin) during QRS similarly as the minimum in depolarization isointegral maps (DIIMmin) and the minimum in isointegral map of the Q wave (Q-IIMmin), lower maximum in repolarization isopotential maps (RIPMmax) and less negative minimum (RIPMmin), more negative amplitude of Q wave (Q-IPMAM) and more pronounced spread of depolarization (activation time). Our results confirmed a decreased parasympathetic to sympathetic tone ratio (tachycardia, shortening of the activation time) and revealed different depolarization and repolarization patterns in DM 1. The differences in heart electric field parameters measured by the BSPM method in DM 1 and in the controls indicate the importance of ECG examination of diabetic patients type 1 in the prevention of cardiovascular diseases., D. Žďárská, P. Pelíšková, J. Charvát, J. Slavíček, M. Mlček, E. Medová, O. Kittnar., and Obsahuje bibiografii a bibliografické odkazy