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52. Příspěvky k dějinám moru v zemích českých z let 1531-1746
- Creator:
- Václav Schulz and Česká akademie císaře Františka Josefa pro vědy, slovesnost a umění
- Publisher:
- Česká akademie císaře Františka Josefa pro vědy, slovesnost a umění
- Format:
- print and 274 s.
- Type:
- text, volume, dokumenty, prameny, model:monograph, and TEXT
- Subject:
- Patologie. Klinická medicína, Historická věda. Pomocné vědy historické. Archivnictví, 16.-18. stol, 1531-1746, mor, epidemie, lékařská péče, dějiny, archivní fondy, Česko, 616.98:579.842, 616-036.22, 616-082, 94(437.3), 930.253, (093), 14, 8, 616, and 930
- Language:
- Czech, German, and Latin
- Description:
- 20, z archivu Musea království českého podává Václav Schulz., KČSN, and 2. přívazek k : Soudní akta konsistoře Pražské, část VI. / Ferdinand Tadra
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
53. Proinflammatory status, genetics and atherosclerosis
- Creator:
- Rudolf Poledne, Alena Lorenzová, Petr Stávek, Zdeněk Valenta, Jaroslav Hubáček, Pavel Suchánek, and Jan Piťha
- Type:
- article, články, model:article, and TEXT
- Subject:
- Patologie. Klinická medicína, klinické lékařství, ateroskleróza, záněty, genetika, clinical medicine, atherosclerosis, inflammations, genetics, C-reaktivní protein, C-reactive protein, 14, and 616
- Language:
- English
- Description:
- Over the last decade, C-reactive protein concentration analyzed by the high sensitivity method (hsCRP) has been proven as a marker of premature atherosclerosis. Concentration exceeding 2 mg/l represents an increased individual risk of myocardial infarction and stroke but strict application of this borderline is complicated by relations of CRP concentrations to other risk factors of cardiovascular diseases. In a large 1 % representative sample of the Czech population, a positive relation of hsCRP to BMI, a waist circumference and triglyceride concentration was documented. Substantial sex differences were found in its relationship to age. Whereas it is continuously increasing in men, this increase appears in women only after menopause. A substantial decrease of body weight and visceral fat volume by increased physical activity is accompanied by significant decrease of hsCRP in young obese women. This decrease was not related to a change of interleukin-6 concentration, although it is supposed to regulate CRP production. CRP concentration is partly under genetic control as a higher concentration in young siblings of probands with proved coronary atherosclerosis was documented. The participation of genes related to lipoprotein metabolism (genes for apolipoprotein CI and apolipoprotein E) influence hsCRP concentrations. We hypothesized that an increased concentration of hsCRP represents a certain marker of proinflammatory status related to central obesity and triglyceride metabolism and it might be related to individual properties of monocytes in atherogenesis., R. Poledne ... [et al.]., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
54. Proteinase-activated receptor-2 expression in breast cancer and the role of trypsin on growth and metabolism of breast cancer cell line MDA MB-231
- Creator:
- Radoslav Matěj, Petra Manďáková, Irena Netíková Štenglová, Pavla Poučková, and Olejár, T.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Patologie. Klinická medicína, molekulární medicína, onkologie, rakovina prsu, molecular medicine, oncology, breast cancer, PAR-2, trypsin, proteinase-activated receptor-2 (PAR-2), 14, and 616
- Language:
- English
- Description:
- a1_Proteinase-activated receptor-2 (PAR-2) is a ubiquitous surface molecule participating in many biological processes. It belongs to the family of G protein-coupled receptors activated by the site-specific proteolysis of trypsin and similar proteases. Altered function of PAR-2 has been described in different malignant tumors. In the present study, we investigated the expression of PAR-2 in breast cancer surgical specimens and the role of trypsin in breast cancer cell line MDA MB-231 proliferation and metabolism. A total of 40 surgical samples of infiltrative ductal breast cancer and breast cancer cell line were included in this study. We analyzed PAR-2 expression by immunohistochemistry, RT-PCR and western blot. Activation of PAR-2 on cell line MDA MB-231 was measured using calcium mobilization assay determined by flow cytometry. MTT cell metabolism assay and cell count analysis were used to assess the trypsin influence on breast cancer cell line MDA MB-231 proliferation. Immunohistochemical examination showed the expression of PAR-2 in all samples of breast cancer surgical specimens and high levels of cell lines which was confirmed by RT-PCR and western blot., a2_Calcium mobilization assay corroborated the activation of PAR-2 on cell line MDA MB-231 either by trypsin or by an agonistic peptide. Cell metabolism assay and cell count analysis showed significant differences of proliferative activity of breast cancer cells dependent on the presence or absence of trypsin and serum in the culture medium. PAR-2 is expressed by high levels in infiltrative ductal breast cancer tissue specimens. PAR-2 is also strongly expressed in studied breast cancer cell lines. PAR-2 is activated by trypsin and also by agonistic peptide in the model of breast cancer cell line MDA MB-231. Activation of PAR-2 in vitro influences proliferative and metabolic activity of breast cancer cell line MDA MB-231. The action of trypsin is modified by the presence of serum which is a potential source of protease inhibitors., R. Matěj, P. Manďáková, I. Netíková, P. Poučková, T. Olejár., and Obsahuje biblografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
55. Relationship between clinical, 24-hour, average day-time and night-time blood pressure and measures of arterial stiffness in essential hypertension
- Creator:
- Jan Rosa, Branislav Štrauch, Ondřej Petrák, Tomáš Pikus, Robert Holaj, Tomáš Zelinka, Dan Wichterle, and Jiří Widimský
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Patologie. Klinická medicína, patologická fyziologie, hypertenze, krevní tlak, pathological physiology, hypertension, blood pressure, arterial stiffness, 24 h blood pressure monitoring, 14, and 616
- Language:
- English
- Description:
- Arterial wall stiffness is considered an independent cardiovascular risk factor. Aim of this study was to evaluate relationship between clinical, 24-hour, average day-time and night-time blood pressure (BP) and measures of arterial stiffness assessed by pulse wave velocity (PWV) (using SphygmoCor applanation tonometer) in essential hypertension (severe-resistant (RH, n=29) and moderate hypertension (EH, n=35)) and in normotensive control subjects (n-29) (NCS) matched by age. After multiple regression analysis, PWV remains significantly correlated mainly with night-time pulse pressure and to a lesser extent with age. PWV was significantly higher in RH compared to moderate EH and NCS., J. Rosa, B. Štrauch, O. Petrák, T. Pikus, R. Holaj, T. Zelinka, D. Wichterle, J. Widimský Jr., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
56. Repetitorium der allgemeinen und speciellen pathologischen Anatomie
- Creator:
- Karel Rokitanský
- Publisher:
- R. Jama
- Format:
- print, text, regular print, and 119 s. ; 23 cm
- Type:
- model:monograph and TEXT
- Subject:
- Patologie. Klinická medicína, patologická anatomie, 616-091, (048.8), 14, and 616
- Language:
- German
- Description:
- nach Rokitansky ; bearbeitet von Rudolf Jama
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
57. Retinoic acid attenuates the mild hyperoxic lung injury in newborn mice
- Creator:
- Madgalena Herknerová, Jaromír Mysliveček, and Petr Potměšil
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Patologie. Klinická medicína, fyziologie, hyperoxie, plíce, physiology, hyperoxia, lungs, retinoic acid, vascular endothelial growth factor, lung injury, newborn mice, 14, and 616
- Language:
- English
- Description:
- Neonatal exposure to hyperoxia alters lung development in mice. We tested if retinoic acid (RA) treatment is capable to affect lung development after hyperoxic injury and to maintain structural integrity of lung. The gene of vascular endothelial growth factor A (VEGF-A) is one of the RA-responsive genes. Newborn BALB/c mice were exposed to room air, 40 % or 80 % hyperoxia for 7 days. One half of animals in each group received 500 mg/kg retinoic acid from day 3 to day 7 of the experiment. At the end of experiment we assessed body weight (BW), lung wet weight (LW), the wet-to-dry lung weight ratio (W/D) and the expression of mRNA for VEGF-A and G3PDH genes. On day 7 the hyperoxia-exposed sham-treated mice (group 80) weighed 20 % less than the room air-exposed group, whereas the 80 % hyperoxic group treated with RA weighed only 13 % less than the normoxic group. W/D values in 80 and 80A groups did not differ, although they both differed from the control group and from 40 groups. There was a significant difference between 40 and 40A groups, but the control group was different from 40 group but not from 40A groups. The 80 and 80A groups had mRNA VEGF-A expression lowered to 64 % and 41 % of the control group. RA treatment of normoxic and mild hyperoxic groups increased mRNA VEGF-A expression by about 50 %. We conclude that the retinoic acid treatment of newborn BALB/c mice exposed for 7 days to 80 % hyperoxia reduced the growth retardation in the 80 % hyperoxic group, reduced the W/D ratio in the 40 % but not in the 80 % hyperoxic group. Higher VEGF-A mRNA expression in the 80 % hyperoxic group treated with RA was not significant compared to the 80 % hyperoxic group., M. Zimová-Herknerová, J. Mysliveček, P. Potměšil., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
58. Staráme se opravdu méně o therapii?
- Creator:
- Ladislav Syllaba
- Publisher:
- Nákladem České akademie věd a umění
- Format:
- print, svazek, and 123 stran.
- Type:
- model:monograph and TEXT
- Subject:
- Patologie. Klinická medicína, terapie, terapeutické postupy, kazuistiky (lékařství), therapy, therapeutic procedures, casuistics, 616-08, 616.1/.9-052-07/-08, (049), 14, and 616
- Language:
- Czech
- Description:
- napsal Lad. Syllaba., KČSN (sg. S-L 403), Z I. kliniky nemocí vnitřních při Universitě Karlově, Předloženo II. třídě dne 4. dubna 1930, and Obsahuje bibliografii a rejstřík
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
59. The role of cardiac surgery in treatment of chronic heart failure
- Creator:
- Jan Pirk
- Type:
- article, články, model:article, and TEXT
- Subject:
- Patologie. Klinická medicína, klinické lékařství, kardiochirurgie, srdeční selhání, human physiology, cardiac surgery, heart failure, koronární revaskularizace, operace chlopní, coronary revascularization, valve surgery, 14, and 616
- Language:
- English
- Description:
- Chronic heart failure has become a significant health problem. Cardiac surgery has an important role in the treatment of patients with heart failure. There are traditional surgical techniques in cardiac surgery – coronary revascularization, valve surgery, ventricular reconstructive surgery as well as new surgical techniques – cardiac support device (CorCap), mechanical circulatory support and resynchronization therapy. Cardiac surgery has a definitive role in the treatment algorithm for chronic heart failure., J. Pirk., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
60. Vznik a význam snů ve zdraví i chorobě
- Creator:
- Antonín Wiesner
- Publisher:
- Nákladem J. Otty
- Format:
- print and 33 s.
- Type:
- model:monograph and TEXT
- Subject:
- Patologie. Klinická medicína, Psychopatologie, sny, psychoanalytické aspekty, snová symbolika, výklad snů, dreams, psychoanalytical aspects, dream symbolism, dream interpretation, 616.8-009.836.15, 159.963.38, (0.062), 14, 17, 616, and 159.97
- Language:
- Czech
- Description:
- napsal Antonín Wiesner. and KČSN
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public