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5452. Boskovice synagogue :
- Creator:
- Sixtová, Olga,
- Type:
- text, statický obraz, and průvodce
- Subject:
- Architektura, synagogy, památky architektonické, přehledná zpracování dějin českých zemí (chronologicky), židovské památky, hřbitovy, synagogy, and jednotlivé památky, památkové rezervace
- Language:
- English
- Description:
- Přeloženo z češtiny
- Rights:
- unknown
5453. Boskovice v historických fotografiích a pohlednicích /
- Creator:
- Filip, Vladimír,
- Type:
- text, statický obraz, and publikace fotografické
- Subject:
- Geografie Česka a Slovenska, reálie, cestování, města, fotografie historické, pohlednice historické, české země 1848-1918, Československo 1918-1992, města, obce, and divadlo, film, fotografie
- Language:
- Czech, English, and German
- Description:
- Hřbetní název: Boskovice
- Rights:
- unknown
5454. Bosnia and Herzegovina under the Communist Regime: an Outlook on Educational Policy /
- Creator:
- Šušnjara, Snjezana
- Type:
- text and studie
- Language:
- English
- Rights:
- unknown
5455. Bosnia, Bosnian Czechs and Migratory Bridges /
- Creator:
- Uherek, Zdeněk,
- Publisher:
- Institute of Ethnology,
- Subject:
- Češi bosenští, migrace, menšiny národnostní, světové dějiny 1789-1918, světové dějiny od r. 1918 do současnosti, Bosna a Hercegovina, Jugoslávie, migrace, vystěhovalectví, kolonizace, české země 1848-1918, and Československo 1918-1992
- Language:
- English
- Rights:
- unknown
5456. Bosnian Study on Markers of Ischaemic Stroke in Adults 20–50 Years Old (SMISAO): preliminary report
- Creator:
- Mahmutbegovic, N., Mehicevic, A., Adler, G., Omerhodzic, I., Mahmutbegovic, E., Valjevac, A., Borecki, K., and Mehmedika Suljic, E.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- stroke, young adults, risk factors, and SNPs
- Language:
- English
- Description:
- Previous research suggested that several genetic polymorphisms are associated with increased risk of ischaemic stroke (IS) in young adults. However, the predictive biomarkers of IS in young adults are still unclear. Our aim was to assess the contribution of modifiable and genetic factors in IS in young adults. In total, 40 stroke patients and 40 healthy controls aged 20 to 50 years were recruited. Data on modifiable factors were collected, then participants were genotyped for seven SNPs linked to thrombophilia: ACE rs1799752, PAI-1 rs1799889, APOE rs1412 and rs429358, FV rs6025 and rs1800595, and FII rs62623459. Significantly increased risk factors: hypertension and dyslipidaemia in stroke patients compared with the controls: 50.0 % vs 27.5 % and 75.0 % vs 40.0% (P = 0.039 and P = 0.002, respectively) were observed. Stroke patients compared with controls did not differ in distribution of ACE, APOE, FV, and FII variants. The 4G4G homozygotes of the PAI-1 gene were significantly more prevalent in stroke patients compared to the controls: 42.5 % vs 17.5 %, (P = 0.033). In the group with the small vessel occlusion subtype of stroke, statistically significant overrepresentation of 4G4G homozygotes and frequency of the 4G allele compared with controls: 57.1 % vs 17.5 % and 0.7 vs 0.45 (P = 0.026 and P = 0.03, respectively) were observed. Independent predictors of stroke incident were: dyslipidaemia (OR (95% CI) = 4.2 (1.4–12.4)) and 4G4G genotype (OR (95% CI) = 3.9 (1.1–13.7)). These results confirm the contribution of dyslipidaemia and 4G4G genotype in the increased risk of IS in young Bosnian adults.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
5457. Bosworth-Toller’s Anglo-Saxon Dictionary online
- Creator:
- Tichý, Ondřej, Roček, Martin, Bočková, Renata, Čermák, Matěj, Dragounová, Jolana, Filipová, Helena, Gilová, Lucie, Hejná, Michaela, Hladíková, Lenka, Hladká, Alena, Hubinová, Veronika, Krajcsovicsová, Vlaďena, Kupková, Tatiana, Lebedeva, Tatiana, Malečková, Nikola, Novotná, Alena, Pazderová, Tereza, Popelíková, Jiřina, Rumlová, Jana, Tyčová Ocelík, Dana, Volná, Veronika, and Zahradníková, Tereza
- Publisher:
- Charles University, Faculty of Arts, Department of English Language and ELT Methodology
- Type:
- text, lexicon, and lexicalConceptualResource
- Subject:
- English, Old English, Anglo-Saxon, dictionary, Bosworth, Toller, lexicography, digitalization, English history, Mediaeval, and Medieval
- Language:
- English, Old English (ca. 450-1100), Latin, Ancient Greek (to 1453), and Ancient Hebrew
- Description:
- Description : This is an online edition of An Anglo-Saxon Dictionary, or a dictionary of "Old English". The dictionary records the state of the English language as it was used between ca. 700-1100 AD by the Anglo-Saxon inhabitants of the British Isles. This project is based on a digital edition of An Anglo-Saxon dictionary, based on the manuscript collections of the late Joseph Bosworth (the so called Main Volume, first edition 1898) and its Supplement (first edition 1921), edited by Joseph Bosworth and T. Northcote Toller, today the largest complete dictionary of Old English (one day to be hopefully supplanted by the DOE). Alistair Campbell's "enlarged addenda and corrigenda" from 1972 are not public domain and are therefore not part of the online dictionary. Please see the front & back matter of the paper dictionary for further information, prefaces and lists of references & contractions. The digitization project was initiated by Sean Crist in 2001 as a part of his Germanic Lexicon Project and many individuals and institutions have contributed to this project. Check out the original GLP webpage and the old Bosworth-Toller offline application webpage (to be updated). Currently the project is hosted by the Faculty of Arts, Charles University. In 2010, the data from the GLP were converted to create the current site. Care was taken to preserve the typography of the original dictionary, but also provide a modern, user friendly interface for contemporary users. In 2013, the entries were structurally re-tagged and the original typography was abandoned, though the immediate access to the scans of the paper dictionary was preserved. Our aim is to reach beyond a simple digital edition and create an online environment dedicated to all interested in Old English and Anglo-Saxon culture. Feel free to join in the editing of the Dictionary, commenting on its numerous entries or participating in the discussions at our forums. We hope that by drawing the attention of the community of Anglo-Saxonists to our site and joining our resources, we may create a more useful tool for everybody. The most immediate project to draw on the corrected and tagged data of the Dictionary is a Morphological Analyzer of Old English (currently under development). We are grateful for the generous support of the Charles University Grant Agency and for the free hosting at the Faculty of Arts at Charles University. The site is currently maintained and developed by Ondrej Tichy et al. at the Department of English Language and ELT Methodology, Faculty of Arts, Charles University in Prague (Czech Republic).
- Rights:
- Creative Commons - Attribution 4.0 International (CC BY 4.0), http://creativecommons.org/licenses/by/4.0/, and PUB
5458. Botanické studie věnované památce Emila Hadače
- Creator:
- Rejmánek , Marcel, Kovář , Pavel, Krahulec , František, and Hadinec , Jiří
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
5459. Botanicus Digital Library
- Type:
- corpus
- Subject:
- Germanistik
- Language:
- Chinese, Czech, English, French, German, Latin, and Spanish
- Description:
- Digital copies of historical botanic papers from the Missouri Botanical Garden Library; Bilddigitalisate von historischen botanischen Schriften; deutschsprachige Texte stellen nur einen Teilbereich dar
- Rights:
- Not specified
5460. Both Caspase and Calpain are involved in endoplasmic reticulum-targeted BNIP3-induced cell death
- Creator:
- Zeng, J., Huang, Y. Y. , Xu, X. M., Li, S. H. , and Zuo, D. C.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- BNIP3, cell death, endoplasmic reticulum, calpain, and caspase
- Language:
- English
- Description:
- Bcl-2/E1B-19K-interacting protein 3 (BNIP3) is a member of the apoptotic B-cell lymphoma-2 family that regulates cell death. Although BNIP3 targeted normally to the mitochondrial outer membrane by its transmembrane domain was originally considered to be essential for its pro-apoptotic activity, accumulating evidence has shown that BNIP3 is localized to endoplasmic reticulum at physiological conditions and that forced expression of BNIP3 can initiate cell death via multiple pathways depending on the subcellular compartment it targets. Targeting BNIP3 to endoplasmic reticulum has been shown to participate in cell death during endoplasmic reticulum stress. However, the molecular events responsible for BNIP3-induced cell death in the endoplasmic reticulum remain poorly understood. In the present study, the transmembrane domain of BNIP3 was replaced with a segment of cytochrome b5 that targets BNIP3 into endoplasmic reticulum, which induced cell death as effectively as its wild-type molecule in the SW480 cell line (colon carcinoma). Furthermore, a pan-caspase inhibitor, z-VAD-fmk, and PD150606, a specific calpain inhibitor, both significantly suppressed the endoplasmic reticulum-targeted BNIP3- induced cell death. These results suggest that endoplasmic reticulum-targeted BNIP3 induced a mixed mode of cell death requiring both caspases and calpains.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public