Insulin resistance is present in patients with Type 2 diabetes mellitus as well as in obese patients without diabetes. The aim of our study was to compare insulin action in diabetic and control persons with or without obesity and to evaluate the influence of serum cholesterol, serum triglyceride and blood pressure on metabolic variables of insulin action. We examined 42 Type 2 diabetic patients and 41 control persons with body mass index (BMI) from 21.1 to 64.5 kg.m-2, and 33 to 71 years old. The isoglycemic hyperinsulinemic clamp technique was performed at an insulin infusion rate of 1 mU.kg-1.min-1 during 120 min. We evaluated the metabolic clearance rate of glucose (MCRG, ml.kg-1.min-1) as the most important indicator of insulin action by isoglycemic clamp. The Pearson's correlation and multiple regression models were used to compare studied factors with the insulin action. We found following predictors of insulin resistance expressed in the relationship with MCRG: BMI (r = -0.68, p<0.001), plasma glucose concentration (r = -0.66, p<0.001), cholesterol (r=-0.55, p<0.001), triglycerides (r = -0.54, p<0.001) and mean blood pressure (r = -0.38, p<0.01). From the multiple regression analysis we conclude that obesity may have even greater influence on the insulin action than diabetes mellitus itself., G. Šindelka, J. Škrha, M. Prázný, T. Haas., and Obsahuje bibliografii
Studie Heleny Matějčkové se zabývá obchodními kontakty mezi hudebním skladatelem Antonínem Dvořákem a londýnským nakladatelem Augener & Co., In the course of research focusing on the history of publication of the works of A. Dvořák, printed editions have been discovered for five works that were issued in 1885 and 1886 by the London publishing house Augener & Co. The literature and sources concerning the life and work of A. Dvořák, however, make no mention of this publisher or of its editions of Dvořák’s music. The study maps the history and activity of the publishing house, devoting the greatest attention to describing the new sources and to consideration of the possible circumstances of their publication – Augener’s editions of Dvořák’s compositions appear to have been prepared on the basis of already issued printings by the Prague publisher F. A. Urbánek – and of aspects of publishing practice at the time, especially with regard to copyright issues., Helena Matějčková., Rubrika: Studie, and Anglické resumé na s. 265, anglický abstrakt 247.
The reports of analgesic effects of benzodiazepines are inconsistent. There is evidence of a hyperalgesic effect induced by activation of supraspinal GABAA receptors and an antinociceptive effect induced by activation of receptors located in the spinal cord (dorsal horns). The aim of the study was to discover whether the systemic administration of a benzodiazepine agent alprazolam increases the systemic analgesic efficacy of non-opioid analgesic ibuprofen. Experimental studies combining these agents have not yet been published. We used three experimental methods - writhing test (with acetic acid), tail-flick test and plantar test to assess analgesic action. The drugs were administered orally. Augmentation of the analgesic effect of ibuprofen by alprazolam was proved for the writhing test at a dose of 30 mg/kg of ibuprofen and alprazolam 1 mg/kg. The reaction time of the combination was significantly prolonged in comparison with ibuprofen alone. The results of the tail-flick test and plantar test were negative. The effect of ibuprofen was not enhanced by alprazolam in tests of acute thermal pain. Our results have demonstrated that the analgesic action of ibuprofen is only weakly enhanced by alprazolam., T. Doležal, M. Kršiak., and Obsahuje bibliografii
a1_Predchádzajúce výskumy naznačujú, že autenticita (pravdivosť v prežívaní a správaní) súvisí s lepším fungovaním blízkych vzťahov. Štúdia je zameraná najmä na partnerskú, resp. vzťahovú autenticitu, teda tendenciu byť autentický voči partnerovi vo vzťahu. Výskum bol zameraný na zistenie korelačných súvislostí autenticity so vzťahovou autonómiou, so sebaúctou, so spokojnosťou a mierou investícií do vzťahu, s dimenziami lásky a s mierou vnímanej prepojenosti partnerov, a to s cieľom overiť, či autenticita partnerov môže predikovať kvalitu partnerského vzťahu. V rámci partnerských dvojíc bola zisťovaná aj miera zhody medzi autenticitou žien a autenticitou mužov, a tiež to, či autenticita jedného partnera súvisí s aspektmi vzťahu sledovanými u druhého partnera (tzv. efekt partnera). Údaje boli zozbierané prostredníctvom batérie dotazníkov (Škála vzťahovej autenticity, Rolový dotazník autenticity, Dotazník autonómie v partnerskom vzťahu, Škála trojuholníku lásky, dimenzie spokojnosť a investície zo Škály investičného modelu, Rosenbergova škála sebahodnotenia a Škála zahrnutosti druhého v sebe) od 189 respondentov vo veku od 18 do 33 rokov, z toho 51 partnerských párov. Výsledky poukázali na štatisticky významné korelácie medzi partnerskou autenticitou a všetkými sledovanými aspektmi partnerského vzťahu, ako aj na nenáhodnú podobnosť partnerov v miere autenticity. Tiež sa preukázal pozitívny efekt autenticity partnera na vzťahovú autonómiu a spokojnosť druhého partnera (u oboch pohlaví). Čo sa týka dimenzií lásky, u žien bol zistený pozitívny efekt autenticity na oddanosť mužov, kým u mužov pozitívny efekt autenticity na mieru intimity žien., a2_ Určitým limitom výskumu môže byť jeho sebavýpoveďový charakter, sociálna žiaducosť sledovaných charakteristík a špecifickosť výskumnej vzorky (prevažne vysokoškolskí študenti, relatívne vysoký podiel študentov psychológie)., b1_Previous research suggests that authenticity (the truth in the experiences and behaviors) is associated with better functioning of close relationships. The study is mainly focused on the partner or relational authenticity, i.e. the tendency to be authentic towards the partner in the relationship. The research was aimed at finding out the correlations of authenticity with relational autonomy, self-esteem, satisfaction and the level of investment in the partnership, dimensions of love, and the extent of perceived connectedness between partners, to verify whether the authenticity of partners may predict the quality of partnership. Then the level of agreement between the authenticity of women and authenticity of men within the couples was assessed, as well as whether the authenticity of one partner is related to aspects of relationship of the other partner (so-called partner´s effect). Data were collected through the battery of questionnaires (Partnership authenticity scale, Role authenticity questionnaire, Autonomy in partnership questionnaire, Triangular love scale, satisfaction and investment dimensions of the Investment model scale, Rosenberg self-esteem scale, and Inclusion of other to the self scale) from 189 respondents aged 18-33 years, including 51 couples. The results showed statistically significant correlations between relational authenticity and all monitored aspects of the partnership, as well as nonrandom similarity between partners in the level of their authenticity. It was also showed the positive effect of partner’s authenticity to relational autonomy and satisfaction (in both sexes). Regarding the dimensions of love, it was found the positive effect of women’s authenticity to the men’s commitment, and positive effect of men’s authenticity to level of women’s intimacy., b2_Certain limits of the research can be its self-report character, social desirability of observed characteristics, and specificity of the research sample (mostly university students, with relatively high proportion of psychology students)., Eva Nábělková, Natália Balážová., and Obsahuje seznam literatury
We investigated the gastric response to an ulcerogenic irritant and the change in gastric functions in an experimental rat model of obstructive jaundice, with or without biliary drainage. After biliary obstruction for 14 days, rats with ligated bile duct (BDL) were randomly divided into three groups: BDL group without biliary drainage, BDL followed by choledochoduodenostomy (CD) or a choledochovesical fistula (CVF). The gastric functions were evaluated 2 weeks after the surgery. Gastric damage, induced by orogastric administration of ethanol, was evaluated 30 min later using a lesion index and microscopic scoring was then performed on fixed stomachs. Basal gastric acid secretion was measured by the pyloric ligation method.The lesion index and maximum lesion depth did not differ in the BDL and sham groups, while they were significantly reduced in the CD group. Gastric acid output and secretory volume were reduced in the BDL group compared to the sham group, while these reductions were abolished in the CD group. Afferent denervation with capsaicin further reduced the ulcer index in the later group. Our data suggest that gastric mucosal susceptibility to injury is dependent on the normal flow of bile into the duodenal lumen, which appears to be a requirement for adaptive gastric cytoprotection., A. Cingi, R. Ahiskali, B. K. Oktar, M. A. Gülpinar, C. Yegen, B.Ç. Yegen., and Obsahuje bibliografii
The two hundred and twenty-fifth anniversary of the Don Giovanni premiere, in 1787, and the one hundred and seventy-fifth anniversary of the foundation, in 1837, of Pragues Mozart Denkmal, the first ever Mozart Memorial Collection, housed from then until now in Pragues Klementinum, offer the opportunity to take a look at Mozarts standing in the early 19th century in Bohemia through the eyes of press and writing on music of the time (August Wilhelm Ambros, Wenzel Johann Tomaschek, Joseph Proksch, Ed. Murelli), as well as period arrangements of his works and the ways of their interpretation., Michaela Freemanová., Obsahuje seznam literatury, and České resumé na s. 102.
Studie Evy Veselovské se zabývá notovanými kodexy, které vznikly na území dnešního Slovenska od 14. do začátku 16. století a do jejichž způsobu notace se promítl vliv českého kulturního prostředí., Recent research of Slovakian medieval notated codices and manuscript fragments raised an important fact: the written culture of the late 14th and 15th centuries in Slovakia was strongly influenced by education from Czech lands. Particularly between 1370 and 1520, the direct impact of the scribal notation tradition from Czech lands to Slovak area can be detected in a number of Slovakian music sources. Codices and dozens of manuscript fragments documenting Bohemian notation in the Slovak geographical area have become the subject of research, along with the systematization, analysis and evaluation of all currently known and edited medieval notated sources from Slovakia. The main purpose of this research is to organise the information gained from these sources, and to determine the general structural features of Bohemian notation in Slovakia., Eva Veselovská., Rubrika: Studie, and Slovenské resumé na s. 376, anglický abstrakt na s. 337.
A large number of songs have been preserved in the Strahov Codex (ca. 1465/67-1470), an important collection of polyphony from the latter half of the fifteenth century. These songs were once generally regarded as cantiones in Latin or as instrumental compositions, but a detailed study of this repertoire shows that the manuscript is an important source of secular compositions, and especially of chansons. Most of these songs have been preserved only in this manuscript. Questions remain as to when they were composed and how they found their way into a manuscript that originated in one of the Catholic regions of Bohemia., Lenka Hlávková-Mračková., and České resumé na s. 270.
Angiotensin converting enzyme (ACE) inhibition has been reported to induce regression of hypertrophy in several models of hemodynamic pressure overload. The aim of the present study was to determine whether the ACE inhibitor captopril can reduce hypertrophy of the left ventricle induced by a chronic volume overload and modify collagen composition of the hypertrophied myocardium. Rabbits with four months lasting aortic insufficiency were divided into two groups: treated with captopril (20 mg/kg/day) for five weeks and treated with placebo. The respective control groups were represented by sham-operated animals. Aortic insufficiency induced a decrease of diastolic pressure, an increase of systolic and pulse pressure, hypertrophy of the left and right ventricle, and an increase of hydroxyproline content in the left ventricle without a change of hydroxyproline concentrations in either ventricle. Captopril treatment further enhanced pulse pressure by decreasing diastolic blood pressure. Hypertrophy of the left ventricle, hydroxyproline content and concentration in both ventricles were unaffected by captopril treatment. It is concluded that ACE inhibition did not reverse the left ventricular hypertrophy developed as a result of overload induced by aortic insufficiency. We suggest that mechanisms different from activation of the renin-angiotensin system may play a decisive role in the maintenance of hypertrophy in this particular model of volume hemodynamic overload., F. Šimko, V. Pelouch, J. Kyselovic., and Obsahuje bibliografii
Pyridoxal isonicotinoyl hydrazone (PIH) is a new tridentate Fe-chelating agent that should be very promising in many pathological states resulting from both an iron-overload and formation of free radicals. The aim of our study was to investigate the effect of PIH on the cardiovascular system focusing to the regulatory protein - cardiac troponin T (cTnT). The study was carried out in two groups of Chinchilla male rabbits: 1) PIH (50 mg/kg dissolved in 10 % Cremophor i.p., once a week, 10 administrations, n=8) and 2) Cremophor (2 ml/kg i.p. in the same schedule, n=7). Plasma concentrations of cTnT (as a marker of myocardial damage) were measured using a commercial kit (Roche). cTnT was within the physiological range (i.e. < 0.1 mg/l) during the whole experiment in the Cremophor group. In the PIH group, the cTnT levels were not significantly increased when compared with the control group or with the initial values (except with those before the 5th administration). Furthermore, we analyzed the cytosolic and myofibrillar fraction of cTnT in the left ventricular myocardium. Using SDS-PAGE and Western blot we resolved three isoforms. The profiling of TnT did not differ significantly between the PIH-treated group and the Cremophor-treated group. Our data concerning cTnT support the opinion that the possible cardiotoxicity of PIH is very low., M. Adamcová, J. Macháčková, V. Geršl, V. Pelouch, T. Šimůnek, I. Klimtová, R. Hrdina, P. Poňka., and Obsahuje bibliografii