Statin-associated myopathy (SAM) represents a broad spectrum of disorders from insignificant myalgia to fatal rhabdomyolysis. Its frequency ranges from 1-5 % in clinical trials to 15-20 % in everyday clinical practice. To a large extent, these variations can be explained by the definition used. Thus, we propose a scoring system to classify statin-induced myopathy according to clinical and biochemical criteria as 1) possible, 2) probable or 3) definite. The etiology of this disorder remains poorly understood. Most probably, an underlying genetic cause is necessary for overt SAM to develop. Variants in a few gene groups that encode proteins involved in: i) statin metabolism and distribution (e.g. membrane transporters and enzymes; OATP1B1, ABCA1, MRP, CYP3A4), ii) coenzyme Q10 production (e.g. COQ10A and B), iii) energy metabolism of muscle tissue (e.g. PYGM, GAA, CPT2) and several others have been proposed as candidates which can predispose to SAM. Pharmacological properties of individual statin molecules (e.g. lipophilicity, excretion pathways) and patients´ characteristics influence the likelihood of SAM development. This review summarizes current data as well as our own results., M. Vrablik, L. Zlatohlavek, T. Stulc, V. Adamkova, M. Prusikova, L. Schwarzova, J. A. Hubacek, R. Ceska., and Obsahuje bibliografii
PATNET, the seismic network of the University of Patras, monitores regularly the seismic activity in the whole western Greece, using for a HYPO location a model, derived as an average representation for this broad area. One of the active regions of the western Greece is the Gulf of Corinth, which central part lies partially on the edge of the PATNET. Due to this and to the fact that the PATNET stations have mostly the vertical component only, the PATNET HYPO location of events in this region are often characterized by large standard errors in epicentres and especially in depths. Using a sequence of small earthquakes that occurred from February to May 2001 close to the city of Aigion, and was recorded by PATNET and as well by local Corinth rift laboratory (CRL) three-component network (CRLNET), we have derived for PATNET station and local model constants whose aplication improves the PATNET HYPO location of events in central part of Gulf of Corinth. These constants represent the main result useful for improvement of the future PATNET location in the given region., Jaromír Janský, Efthimios Sokos, Anna Serpetsidaki and Helene Lyon-Caen., and Obsahuje bibliografické odkazy
We introduce statisch pairs in atomistic posets and study its relationships with some known concepts in posets such as biatomic and dual modular pairs, perspectivity and subspaces of atom space of an atomistic poset. We generalize the notion of exchange property in posets and with the help of it we prove the equivalence of dual modular, biatomic and statisch pairs in atomistic posets. Also, we prove that the set of all finite elements of a statisch poset with such property forms an ideal. ∇-relation is partly studied by means of statisch pairs.
A historical and instrumental earthquake catalogue is prepared for the Northwest Himalayan Fold and Thrust Belt and Makran Subduction Zone Pakistan from 1960 to 2019 with homogenized moment magnitude. The local and some international published sources were utilized for the preparation of catalogue. This earthquake catalogue contained numbers of duplicate, repeated, dependent and independent events. Declustering process was opted to remove the dependent events such as foreshock and aftershock from catalogue to separate the mainshock only in term of distance and time space window. The declustering found 2714 clusters of earthquakes with total of 19512 (57.19 %) events out of 34112. Only cluster events which contained the mainshock or independent events were drawn on seismicity map with color identification. Maximum likelihood method was used to compute the value of magnitude of completeness i.e., Mc = 3.8 with estimation of a and b-values. Years vise magnitude of completeness was also computed to check the time period variation. The completeness of magnitude for different intervals of time indicates the impartial approximation of previous recorded seismicity. Temporal and spatial maps were also drawn to investigate the slope “b” and rate of productivity “a” in the study region. It is noted that b-values varied from 0.2 to 2.0 due to stress and intensive tectonic setting whereas a value increases due to increase the seismicity rate with respect to region. Seismotectonic map was drawn to delineate the major faults, seismicity pattern and tectonic activities. This work further can be used for single value hazard assessment for any region and their response spectra to update buildings and bridges codes.
In this paper we study in detail the associativity property of the discrete copulas. We observe the connection between discrete copulas and the empirical copulas, and then we propose a statistic that indicates when an empirical copula is associative and obtain its main statistical properties under independence. We also obtained asymptotic results of the proposed statistic. Finally, we study the associativity statistic under different copulas and we include some final remarks about associativity of samples.
.In the paper D. Hoover, J. Keisler: Adapted probability distributions, Trans. Amer. Math. Soc. 286 (1984), 159–201 the notion of adapted distribution of two stochastic processes was introduced, which in a way represents the notion of equivalence of those processes. This very important property is hard to prove directly, so we continue the work of Keisler and Hoover in finding sufficient conditions for two stochastic processes to have the same adapted distribution. For this purpose we use the concept of causality between stochastic processes, which is based on Granger's definition of causality. Also, we provide applications of our results to solutions of some stochastic differential equations.
The Surface Water Department of the Czech Hydrometeorological Institute in 2006 selected a new period for the evaluation of hydrological characteristics of mean daily discharge series. Initially, two fortyyear long periods were considered: 1961-2000 and 1966-2005 and the period of 1961-2005 was finally accepted. Comparison of the still used 1931-1980 period with the new one was carried out using the data from 50 Czech gauging stations that had continuous data time series. The mean long-term runoff of Czech rivers changed very little from 1931-1980 to 1961-2005. Comparison of the variation coefficients brought similar results. However, among specific M-day discharges the low flow values (e.g. Q355d) showed a significant increase. This might reflect not only natural causes but could suggest anthropogenic factors as well. Trend analyses started with testing mean annual runoff at 65 Czech gauging stations that were not influenced by human activity. 34 stations showed an increasing trend and 31 a decreasing trend. However, the trend was statistically significant only at one station. Trends of individual months dramatically differentiate. In January through March the increasing trends prevail. March trends show the highest number of stations with a significant increase. The three following months are complete opposites in which decreasing trends dominate. In May and June, not a single increase was recorded and many decreases were statistically significant. Almost no significant trends were examined in the months of the second half of the year. and V posledních měsících se oddělení povrchových vod ČHMÚ zabývalo výběrem období pro výpočet nových hydrologických charakteristik M-denních průtoků na českých tocích. Uvažována byla čtyřicetiletí 1961-2000 a 1966-2005, nakonec však bylo přijato období 1961-2005. Na datech z 50 vodoměrných stanic, které měly nepřerušené řady pozorování, bylo uskutečněno první srovnání statistických charakteristik období 1931-1980 (doposud používané) a 1961-2005. U nového období byly u neovlivněných stanic vyhodnoceny trendy průměrných ročních průtoků a průtoků jednotlivých měsíců.