AIM: The ability of two newly developed oximes (K727, K733) to reduce tabun-induced acute neurotoxic signs and symptoms was evaluated and compared with currently available trimedoxime in rats. METHODS: The neuroprotective effects of the oximes studied combined with atropine on Wistar rats poisoned with tabun at a lethal dose (380 µg/kg i.m.; 90% of LD50 value) were evaluated. Tabun-induced neurotoxicity was monitored by the functional observational battery consisting of 38 measurements of sensory, motor and autonomic nervous functions at 2 hours following tabun challenge. RESULTS: All tested oximes combined with atropine enable tabun-poisoned rats to survive till the end of experiment. Both newly developed oximes (K727, K733) combined with atropine were able to decrease tabun-induced neurotoxicity in the case of lethal poisoning although they did not eliminate all tabun-induced acute neurotoxic signs and symptoms. CONCLUSION: The ability of both novel bispyridinium oximes to decrease tabun-induced acute neurotoxicity was slightly lower than that of trimedoxime. Therefore, the newly developed oximes are not suitable for the replacement of commonly used oximes such as trimedoxime in the treatment of acute tabun poisonings. and J. Kassa, J. Hatlapatková, J. Žďárová Karasová
We have studied the height dependent characteristics of the Evershed flow in the photosphere, chromosphere and chromosphere-corona transition region. We have used the Multichannel Subtractive Double Pass Spectrograph (MSDP) to
obtain line of sight velocity maps in Hα, the Meudon magnetograph for mapping the photospheric velocity field and the Ultraviolet Spectrometer and Polarimeter (UVSP) on the Solar Maximum Mission (SMM) spacecraft to obtain line of sight velocities in C IV, in sunspot regions. Our emphasis was on the large scale,
quasi-stationary characteristics of the flow. In the photosphere the velocity is low above the umbra and shows a maximum above the penumbra. In addition to the reversal of the flow in the chromosphere both the characteristic scale of the flow and the velocity are larger; the velocity maximum is located outside the photospheric penumbra. In the chromosphere-corona transition
region there is a clear tendency for a chromospheric-type Evershed effect with a predominantly horizontal flow. The velocity is greater than in the chromosphere, but the characteristic scale of the flow is about the same. In addition to the Evershed flow, C IV observations show upflows above the umbra with a velocity of about 15 km/sec.
Although a monophyletic group, male (XX/XY) and female heterogametic (WZ/ZZ) sex chromosome systems with a couple of variants like XX/X, Z/ZZ and multiple sex chromosome systems occur in insects. Molecular and morphological differences between X and Y or W and Z range from imperceptible to conspicuous. This article illustrates sex chromosome differentiation mainly in two fly species, Drosophila melanogaster and Megaselia scalaris, and in Lepidoptera. The earliest phases of XY evolution are present in the fly M. scalaris. Occasionally in this species, the male determining gene jumps to another chromosome, transforming the new host chromosome to a functional Y chromosome. Thus, in M. scalaris there are strains with virtually no XY differentiation (except for the sex determining function) and others with a moderate degree of differentiation. Base substitutions and alterations like sequence deletions, duplications, and insertions of mobile sequences mark the onset of molecular differentiation. Accumulation of molecular changes and coarser alterations are thought to lead to the morphological differences seen in WZ chromosome pairs of Lepidoptera. The W chromosome probably evolved in the most numerous clade of Lepidoptera, the Ditrysia, after it diverged from the common lepidopteran stem. Extant species display various degrees of molecular and morphological differentiation of the W chromosome, translocation or fusion with autosomes, and loss of the W.
Taste is important for food intake. The fetus first experiences taste through amniotic fluid, and later via mother’s milk. Early human experience with taste has a key importance for later acceptance of food. Dietary behavior is determined by the interaction of many different factors. The development of the olfactory and taste receptors begins at 7-8 weeks of gestation. An early sensitive period probably exists when flavor preference is established. Sweet taste is preferred in early childhood; this is the reason why children are at increased risk of over-consuming saccharides. Gustatory sensitivity declines with age. The threshold for the perception of each basic taste differs, and is established genetically. In this review, we summarize published data on taste preferences and its development and changes during life., Š. Podzimek, M. Dušková, Z. Broukal, B. Rácz, L. Stárka, J. Dušková., and Obsahuje bibliografii
Most of the work on exact models representing gravitational waves in general relativity has been concerned with spacetimes which are,at least in some directions, asymptotically flat. Here we treat gravitational waves in one of the simplest but everywhere curved cosmological model. We give the physical interpretation of exact "type - N solutions" of Einstein´s equations with cosmological constant presented recently by García Días and Plebanski. We show that some of these solutions may be interpreted as gravitational waves propagating in the de Sitter universe. (According to present consensus, this unvierse represents the inflationary stage of our Universe.) The analysis also reveals that tha solutions can serve as the illustration of the cosmological no-hair theorem: they approach the de Sitter space-time asymptotically in time.
In this paper, the feedback control for a class of bilinear control systems with a small parameter is proposed to guarantee the existence of limit cycle. We use the perturbation method of seeking in approximate solution as a finite Taylor expansion of the exact solution. This perturbation method is to exploit the "smallness" of the perturbation parameter ε to construct an approximate periodic solution. Furthermore, some simulation results are given to illustrate the existence of a limit cycle for this class of nonlinear control systems.
Effect algebras are very natural logical structures as carriers of probabilities and states. They were introduced for modeling of sets of propositions, properties, questions, or events with fuzziness, uncertainty or unsharpness. Nevertheless, there are effect algebras without any state, and questions about the existence (for non-modular) are still unanswered. We show that every Archimedean atomic lattice effect algebra with at most five blocks (maximal MV-subalgebras) has at least one state, which can be obtained by "State Smearing Theorem'' from a state on its sharp elements.