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2042. ZBTB16 and metabolic syndrome: a network perspective
- Creator:
- Ondřej Šeda, Lucie Šedová, Josef Včelák, Marie Vaňková, František Liška, and Běla Bendlová
- Format:
- print, bez média, and svazek
- Type:
- article, články, journal articles, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, animal models, metabolic syndrome, systems biology, pleiotropy, 14, and 612
- Language:
- English
- Description:
- Metabolic syndrome is a prevalent, complex condition. The search for genetic determinants of the syndrome is currently undergoing a paradigm enhancement by adding systems genetics approaches to association studies. We summarize the current evidence on relations between an emergent new candidate, zinc finger and BTB domain containing 16 (ZBTB16) transcription factor and the major components constituting the metabolic syndrome. Information stemming from studies on experimental models with altered Zbtb16 expression clearly shows its effect on adipogenesis, cardiac hypertrophy and fibrosis, lipid levels and insulin sensitivity. Based on current evidence, we provide a network view of relations between ZBTB16 and hallmarks of metabolic syndrome in order to elucidate the potential functional links involving the ZBTB16 node. Many of the identified genes interconnecting ZBTB16 with all or most metabolic syndrome components are linked to immune function, inflammation or oxidative stress. In summary, ZBTB16 represents a promising pleiotropic candidate node for metabolic syndrome., O. Šeda, L. Šedová, J. Včelák, M. Vaňková, F. Liška, B. Bendlová., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2043. ZBTB16 gene variability influences obesity-related parameters and serum lipid levels in Czech adults
- Creator:
- Běla Bendlová, Marie Vaňková, Hill, M., Vacínová, G., Petra Lukášová, Daniela Vejražková, Lucie Šedová, Ondřej Šeda, and Josef Včelák
- Format:
- print, bez média, and svazek
- Type:
- article, články, journal articles, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, lipidy, lipids, body fat distribution, ZBTB16, multivariate regression, body mass index, 14, and 612
- Language:
- English
- Description:
- The data derived from rat models and the preliminary results of human studies provide strong indices of involvement of common ZBTB16 variants in a range of cardiovascular and metabolic traits. This cross-sectional study in the Caucasian cohort of 1517 Czech adults aimed to verify the hypothesis that ZBTB16 gene variation directly affects obesity and serum lipid levels. Genotyping of nine polymorphisms of the ZBTB16 gene (rs11214863, rs593731, rs763857, rs2846027, rs681200, rs686989, rs661223, rs675044, rs567057) was performed. A multivariate bidirectional regression with the reduction of dimensionality (O2PLS model) revealed relationships between basal lipid levels and anthropometric parameters and some minor ZBTB16 alleles. In men, the predictors - age and presence of minor ZBTB16 alleles of rs686989, rs661223, rs675044, rs567057 - were associated with significantly higher body mass index, waist to hip ratio, body adiposity index, waist and abdominal circumferences, higher total cholesterol and LDL cholesterol and explained 20 % of variability of these variables. In women, the predictors - age and presence of the rs686989 minor T allele - were also associated with increased anthropometric parameters and total cholesterol and LDL cholesterol but the obtained O2PLS model explained only 7.8 % of the variability of the explained variables. Our study confirmed that the selected gene variants of the transcription factor ZBTB16 influence the obesity-related parameters and lipid levels. This effect was more pronounced in men., B. Bendlová, M. Vaňková, M. Hill, G. Vacínová, P. Lukášová, D. Vejražková, L. Šedová, O. Šeda, J. Včelák., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2044. Zdraví - nejen téma 7. rámcového programu
- Creator:
- Perglová, Táňa
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Hygiena. Lidské zdraví, Evropská unie., Rámcový program pro výzkum a technologický rozvoj, 7., zdraví, zdravotnický výzkum, health, health care research, 14, and 613
- Language:
- Czech
- Description:
- Táňa Perglová.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2045. Zdravověda
- Creator:
- Gustav Kabrhel
- Publisher:
- Bursík & Kohout
- Format:
- print, text, regular print, and 748 s. : il. ; 4°
- Type:
- model:monograph and TEXT
- Subject:
- Veřejné zdraví a hygiena, ovzduší, půda, klima, zásobování, voda, stavby, větrání, osvětlení, odpadové hospodářství, 614, 14, and US01
- Language:
- Czech
- Description:
- Gustav Kabrhel, Vydáno za podpory České akademie pro vědy a umění z fondu Šíchova, and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2046. Zdravověda: kniha pro každého
- Creator:
- Panýrek, Duchoslav
- Publisher:
- F. Šimáček
- Format:
- print, text, regular print, and xiii, 359 s., [1] l. barev. obr. příl. : il. (některé barev.) ; 18 cm
- Type:
- model:monograph and TEXT
- Subject:
- Lékařské vědy. Lékařství, zdravověda, 61, (048.8), and 14
- Language:
- Czech
- Description:
- Duchoslav Panýrek, Obsahuje rejstřík, and S 61 obrázky a 1 chromolithografií
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2047. Zdroje lékařského vědění a umění
- Creator:
- Eduard Albert, Haškovec, Ladislav, and Otto, Jan
- Publisher:
- J. Otto
- Format:
- print and 36 s. : il.
- Type:
- model:monograph and TEXT
- Subject:
- Lékařské vědy. Lékařství, dějiny lékařství, 61(091), (046), 14, and 61
- Language:
- Czech
- Description:
- napsal Eduard Albert.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2048. Životní magnetismus: praktická příručka ke studiu a léčbě životním magnetismem
- Creator:
- Karel Weinfurter
- Publisher:
- Zmatlík a Palička
- Format:
- print, text, regular print, and 202 s., [11] s. obr. příl. : il. ; 19 cm
- Type:
- text, volume, handbook, biography, příručky, model:monograph, and TEXT
- Subject:
- Fyzioterapie. Psychoterapie. Alternativní lékařství, magnetismus, magnetoterapie, alternativní terapie, 537.6, 615.849.11, 615.8, (035), and 14
- Language:
- Czech
- Description:
- Karel Weinfurter and Obsahuje bibliografické odkazy
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2049. α-actin down regulation and perforin loss in uterine natural killer cells from LPS-treated pregnant mice
- Creator:
- Zavan, B., Amarante-Paffaro A. M. do, and Paffaro, V. A.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, těhotenství, fyziologie, pregnancy, physiology, α-actin, perforin, UNK, lipopolysaccharide, mouse, 14, and 612
- Language:
- English
- Description:
- One of the most abundant immunologic cell types in early decidua is the uterine natural killer (UNK) cell that despite the presence of cytoplasmic granules rich in perforin and granzymes does not degranulate in normal pregnancy. UNK cells are important producers of angiogenic factors that permit normal dilation of uterine arteries to provide increased blood flow for the growing feto-placental unit. Gram-negative bacteria lipopolysaccharide (LPS) administration can trigger an imbalance of pro-inflammatory and anti-inflammatory cytokines impairing the normal immune cells activity as well as uterine homeostasis. The present study aimed to evaluate by immunohistochemistry the reactivity of perforin and α-actin on UNK cell from LPStreated pregnant mice. For the first time, we demonstrate that LPS injection in pregnant mice causes α-actin down regulation, concomitantly with perforin loss in UNK cells. This suggests that LPS alters UNK cell migration and activates cytotoxic granule release., B. Zavan, A. M. do Amarante-Paffaro, V. A. Paffaro Jr., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public