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2. Effects of Short-Period Exercise Training and Orlistat Therapy on Body Composition and Maximal Power Production Capacity in Obese Patients

Creator:
Colak, R. and Ozcelik, O.
Type:
article, model:article, and TEXT
Subject:
Obesity, Body mass index, and Aerobic exercise intensity
Language:
English
Description:
We examined the effects of weight loss induced by diet-orlistat (DO) and diet-orlistat combined with exercise (DOE) on maximal work rate production (Wmax) capacity in obese patients. Total of 24 obese patients were involved in this study. Twelve of them were subjected to DO therapy only and the remaining 12 patients participated in a regular aerobic exercise-training program in addition to DO therapy (DOE). Each patient performed two incremental ramp exercise tests up to exhaustion using an electromagnetically-braked cycle ergometer: one at the onset and one at the end of the 4th week. DOE therapy caused a significant decrease in total body weight: 101.5±17.4 kg (basal) vs 96.3±17.3 kg (4 wk) associated with a significant decrease in body fat mass: 45.0±10.5 kg (basal) vs 40.9±9.8 kg (4 wk). DO therapy also resulted in a significant decrease of total body weight 94.9±14.9 kg (basal) vs 91.6±13.5 kg (4 wk) associated with small but significant decreases in body fat mass: 37.7±5.6 kg (basal) to 36.0±6.2 kg (4 wk). Weight reduction achieved during DO therapy was not associated with increased Wmax capacity: 106±32 W (basal) vs 106±33 W (4 wk), while DOE therapy resulted in a markedly increased Wmax capacity: 109±39 W (basal) vs 138±30 W (4 wk). DO therapy combined with aerobic exercise training resulted in a significant reduction of fat mass tissue and markedly improved the aerobic fitness and Wmax capacities of obese patients. Considering this improvement within such a short period, physicians should consider applying an aerobic exercise-training program to sedentary obese patients for improving their physical fitness and thereby reduce the negative outcomes of obesity.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. Relationship between cough reflex sensitivity and body mass index in children with chronic cough - a pilot study

Creator:
Pecova, Renata, Sojak, Jan, Durdik, Peter, Zatko, Tomas, Omar Mohamedova, Eva, Grendar, Marian, and Tatar, Milos
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
cough, chronic cough, cough reflex sensitivity, Body mass index, children, and atopy
Language:
English
Description:
Obesity is characterized by chronic, low-grade systemic inflammation. Obesity may also be associated with chronic cough. The aim of this pilot study was to clarify relation of cough reflex sensitivity and body mass index (BMI) in children with chronic cough. Altogether 41 children having symptoms of chronic cough were submitted to cough reflex sensitivity measurement. We assessed the relation of cough reflex sensitivity (CKR) due to BMI. Cough reflex sensitivity was defined as the lowest capsaicin concentration which evoked two (C2) or five (C5) coughs. Capsaicin aerosol in doubling concentrations (from 0.61 to 1250 µmol/l) was inhaled by a single breath method (KoKo DigiDoser; nSpire heath Inc, Louisville, CO, USA), modified by the addition of an inspiratory flow regulator valve (RIFR; nSpire heath Inc, Louisville, CO, USA). BMI was calculated. Pulmonary function was within normal range. Concentrations of capsaicin causing two (C2) and five coughs (C5) were reported. Children' (22 boys and 19 girls, mean age 6.8 years) cough reflex sensitivity (median, with the InterQuartile Range) for C2 was 19.5 (73.4) µmol/l; for C5 it was 78.1 (605.5) µmol/l. We have noticed statistically significant relation of the cough reflex sensitivity (C5) and body mass index (P<0.0001); however, the effect size was small, R2 =0.03. Increase of body mass index in one unit is associated with -34.959 µmol/l decrease of C5. We did not find a statistically significant relation between C2 and BMI (P=0.41). The median value of CKR (C2) in boys is not statistically significantly different than the median value of CKR (C2) in girls (P-value 0.5). The median value of CKR (C5) in boys is not statistically significantly different than the median value of CKR (C5) in girls (P-value 0.5). Increase of body mass index in children suffering from chronic cough relates to decrease of cough reflex sensitivity (C5 value).
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public