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1. Renal Concentrating Capacity is Linked to Blood Pressure in Children with Autosomal Dominant Polycystic Kidney Disease

Creator:
Seeman, T., Dušek, J., Vondrák, K., Bláhová, K., Šimková, E., Kreisinger, J., Dvořák, P., Kynčl, M., Hříbal , Z., and Janda, J.
Type:
article, model:article, and TEXT
Subject:
Renal concentrating capacity test, Autosomal dominant polycystic kidney disease, Blood pressure, Hypertension, and Children
Language:
English
Description:
Impaired glomerular filtration rate (GFR) is a risk factor for the development of hypertension in patients with autosomal dominant polycystic kidney disease (ADPKD). However, markers of tubular function were not tested whether they are linked to hypertension or blood pressure (BP) level. The aim of our study was to investigate the relationship between renal concentrating capacity and BP in children with ADPKD. Fifty-three children (mean age 11.84.4 years) were investigated. Standardized renal concentrating capacity test was performed after nasal drop application of desmopressin, BP was measured by ambulatory BP monitoring (ABPM). Renal concentrating capacity was decreased in 58 % of children. The prevalence of hypertension was significantly higher in children with decreased renal concentrating capacity (35 %) than in children with normal renal concentrating capacity (5 %) (p0.05). Significant negative correlations were found between renal concentrating capacity, ambulatory BP and number of renal cysts (r = –0.29 to –0.39, p0.05 to p0.01). In conclusion, the concentrating capacity is decreased in about half of the patients and is linked to BP. Decreased renal concentrating capacity should be considered as an early marker of functional impairment in ADPKD and a further risk factor for hypertension.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Tzv. práce s dětmi jako součást socialistické mimoškolní výchovy v 50. a 60. letech

Creator:
Knapík, Jiří
Type:
article, model:article, and TEXT
Subject:
Children, Extracurricular Education, Pioneer Movement, Media, and Propaganda
Language:
Czech
Description:
The activities of the so-called work with children was a part of Socialist extracurricular education which was further augmented by founding unique facilities for children of pioneer age. The paper describes the profile of selected events and their conceptual changes during the 1950s and 1960s.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3. Vitamin D in autistic children and healthy controls

Creator:
Bičíková, M. , Máčová, L., Ostatníková, D., and Hanzlíková, L.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
Vitamin D, Children, Calcidiol, Calcitriol, and Autism
Language:
English
Description:
Insufficient levels of vitamin D have been demonstrated by many authors as a risk factor for autistic patients, however, the causality has not been reliably elucidated. In the present study, levels of calcidiol were determined in group of autistic children and compared with age matched healthy children as controls. Suboptimal levels of calcidiol in more than 60 % of both autistic patients as well as of control group were found. No significant differences in vitamin D between autistic children and healthy controls were observed.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public