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Start Over Subject Extracellular matrix

1. Influence of Macrophages and Macrophage - Modified Collagen I on the Adhesion and Proliferation of Vascular Smooth Muscle cells in Culture

Creator:
Bačáková, L., Herget, J., and Wilhelm, J.
Type:
article, model:article, and TEXT
Subject:
Remodeling of vascular wall, Cell adhesion, Cell growth, Spontaneous cell detachment, Reactive oxygen species, Activated macrophanges, Rat aotric smooth muscle cells, Coculture, and Extracellular matrix
Language:
English
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. The extracellular matrix and Ca2+ signaling mechanisms

Creator:
Filip, S., Mokrý, J., Forostyak, O., and Dayanithi , G.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
Extracellular matrix, Ca2+ signaling, Homeostasis, Skeletal muscles, and Muscle remodeling
Language:
English
Description:
The extracellular matrix (ECM) consists of proteins, glycosaminoglycans and glycoproteins, that support the dynamic interactions between cells, including intercellular communication, cell attachment, cell differentiation, cell growth and migration. As such, the ECM represents an essential and very sensitive system within the tissue microenvironment that is involved in processes such as tissue regeneration and carcinogenesis. The aim of the present review is to evaluate its diversity through Ca2+ signaling and its role in muscle cell function. Here, we discuss some methodological approaches dissecting Ca2+ handling mechanisms in myogenic and non-myogenic cells, e.g. the importance of Ca2+ and calpains in muscle dystrophy. We also consider the reconstruction of skeletal muscle by colonization of decellularized ECM with muscle-derived cells isolated from skeletal muscle. Therefore, it is necessary to establish new methodological procedures based on Ca2+ signaling in skeletal muscle cells and their effect on ECM homeostasis, allowing the monitoring of skeletal muscle reconstruction and organ repair.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3. The role of the carbohydrates in plasmatic membrane

Creator:
Sprovieri, P and Martino, G
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
fyziologie člověka, human physiology, Cell adhesion, Extracellular matrix, Cell membrane, Glycans, Human health, 14, and 612
Language:
English
Description:
In the following paper, authors describe glycans present on cell membranes as they affect the folding, the spatial arrangement, the behavior and the interaction with the substrate of some membrane proteins. Authors describe the synthesis and assembly of a glycan on a protein, the formation of N-glycans, the maturation of an N-glycan in different cellular compartments, the structure of the glycocalyx and how it interacts with any pathogens. The study of the E-cadherin and the potassium channel to demonstrate how glycans affect the spatial arrangement, the stability and activity of the glycoproteins on the membranes. Subsequently, authors analyze the correlation between disorder glycosylation and human health. Authors define glycosylation disorders as a genetic defect that alter the structure or biosynthesis of glycans (sugar chains) in one or more biosynthetic pathways. Human glycosylation disorders reflect the disruption of early steps in the pathways of glycan biosynthesis. More in details, authors analyze the role of glycoprotein in tumor cell adhesion, in particular, in cells MCF-7 and MDA-MB-231 on zeolite scaffold. In the same time, the role of metalloproteinase is described in the mobilization of cancer cells and in metastasis., P. Sprovieri, G. Martino., and Seznam literatury
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public