A review of genera within the tribe Lyropaeini is given. Three new genera - Lyrolib gen. n., Horakiella gen. n., and Ambangia gen. n., and a subgenus Macroambangia subgen. n. within Ambangia gen. n. are described. The following twelve new species are proposed as new to science: Ambangia nigra sp. n. (Sulawesi), A. wallacei sp. n. (Sulawesi), Ambangia (Macroambangia) pallidicornis sp. n. (Sulawesi), A. (M.) celebensis sp. n. (Sulawesi), A. (M.) nigricornis sp. n. (Sulawesi), Alyculus wittmeri sp. n. (Sumatra), Horakiella hammondi sp. n. (Malaysia: Sarawak), H. pahangana sp. n. (Peninsular Malaysia), H. emasensis sp. n. (Malaysia: Sabah), Lyrolib minor sp. n. (Sulawesi), L. grandis sp. n. (Sulawesi), and Microlyropaeus dembickyi sp. n. (Sumatra). A key to genera of Lyropaeini is given, and comments on their relationships are provided.