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Start Over Subject biomedicína Type články

1. Centrum translační biomedicíny v Terezíně a Litoměřicích

Creator:
Eva Syková and Josef Syka
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, Ústav experimentální medicíny (Akademie věd ČR), výzkum a vývoj, biomedicína, regenerační medicína, research and development, biomedicine, regenerative medicine, 12, and 00
Language:
Czech
Description:
Eva Syková, Josef Syka.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3. Distinct patterns of histone methylation and acetylation in human interphase nuclei

Creator:
Magdalena Skalníková, Eva Bártová, Vladimír Ulman, Pavel Matula, David Svoboda, Andrea Harničarová, Michal Kozubek, and Stanislav Kozubek
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, biomedicína, chromozomy, počítačová analýza obrazu, human physiology, biomedicine, chromosomes, computer image analysis, histone methylation, acetylation, centromeres, 14, and 612
Language:
English
Description:
To study 3D nuclear distributions of epigenetic hist one modifications such as H3(K9) acetylation, H3(K4) dimethylation, H3(K9) dimethylation, and H3(K27) trimethylation, and of histone methyltransferase Suv39H1, we used advanced image analysis methods, comb ined with Nipkow disk confocal microscopy. Total fluorescence intensity and distributions of fluorescently labelled proteins were analyzed in formaldehyde-fixed interphase nuclei. Our data showed reduced fluorescent signals of H3(K9) acetylation and H3(K4) dimethylation (di-me) at the nuclear periphery, while di-meH3(K9) was also abundant in chromatin regions closely associated with the nuclear envelope. Little overlapping (intermingling) was observed for di-meH3(K4) and H3(K27) trimethylation (tri-me), and for di-meH3(K9) and Suv39H1. The histone modifications studied were absent in the nucleolar compartment with the exception of H3(K9) dimethylation that was closely associated with perinucleolar regions which are formed by centromeres of acrocentric chromosomes. Using immunocytochemistry, no di-meH3(K4) but only dense di-meH3(K9) was found for the human acrocentric chromosomes 14 and 22. The active X chromosome was observed to be partially acetylated, while the inactive X was more condensed, located in a very peripheral part of the interphase nuclei, and lacked H3(K9) acetylation. Our results confirmed specific interphase patterns of histone modifications within the interphase nuclei as well as within their chromosome territories., M. Skalníková, E. Bártová, V. Ulman, P. Matula, D. Svoboda, A. Harničarová, M. Kozubek, S. Kozubek., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

4. Euro-Biolmaging: síť pro zobrazování v biomedicíně

Creator:
Pavel Hozák and Morská, Markéta
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, biologie, biomedicína, akademické počítačové sítě, biology, biomedicine, academic computer networks, 12, and 00
Language:
Czech
Description:
Euro-Biolmaging is a large scale pan European research infrastructure project on the European Strategy Forum on Research Infrastructures (ESFRI) Roadmap. Euro-Biolmaging will deploy a distributed biological and biomedical imaging infrastructure in Europe in a coordinated and harmonized manner. By providing access to and training in imaging technologies, and by sharing of best practice and image data, Euro-Biolmaging will become an engine that will drive European innovation in imaging research and technologies. and Pavel Hozák, Markéta Morská.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5. Inovační biomedicínské centrum otevřeno

Creator:
Eva Syková
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, Ústav experimentální medicíny (Akademie věd ČR), biomedicína, podpora vědy a výzkumu, inovace, biomedicine, government aid to research, innovations, 12, and 00
Language:
Czech
Description:
Innovation Biomedical Centre (IBC) is a multipurpose and newly constructed facility located near to the Institute of Experimental Medicine (Academy of Sciences of the Czech Republic) in Prague-Krč. It was erected between August 2007 and March 2008 at a total cost of 2,1 Mil EURO. IBC was inaugurated by Prime Minister Mirek Topolánek on October 7 2008. and Eva Syková.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

6. Kritika povinného očkování v ČR: charakteristiky rodičů a diskurzivní rámce, které využívají

Creator:
Jaroslava Hasmanová Marhánková and Skálová, Jitka
Format:
print, bez média, and svazek
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Sociologie, výzkum veřejného mínění, public opinion polls, očkování, biomedicína, vaccination, biomedicine, Česko, Czechia, odmítnutí očkování, anti-vaccination movement, discourse, vaccination refusal, 18, and 316
Language:
Czech
Description:
Československo resp. Česká republika má dlouholetou tradici v oblastech očkování, přičemž míra proočkovanosti v současné době dosahuje 98-99 %. Zákon zároveň ukládá povinnost podrobení se očkování všem jedincům žijícím na území České republiky. Z hlediska zákona je člověk, který odmítá očkování svého dítěte, v pozici občana/ky dopouštějící/ho se přestupku a ohrožující/ho ochranu veřejného zdraví. Přestože je mnoha odborníky/cemi očkování považováno za jeden z největších úspěchů medicíny, ne všichni členové/ky české společnosti nahlížejí na povinné očkování jako na jednoznačné pozitivum. Tento text se zaměřuje na problematiku kritiky očkování v České republice perspektivou rodičů, kteří takovýto postoj zaujímají. Cílem tohoto textu je představit sociodemografické charakteristiky rodičů, kteří se kriticky staví k očkování, a zároveň diskurzy, které při své argumentaci mobilizují. Text vychází z dotazníkového šetření mezi rodiči, kteří kriticky vystupují vůči praxi očkování. Dotazník byl umístěn na webových stránkách občanského sdružení Rozalio, které představuje nejvýraznější a největší organizaci sdružující rodiče kritické k praxi povinného očkování v ČR. Šetření se zúčastnilo 372 respondentů/tek. Rodiče v dotazníku dostali rovněž prostor vlastními slovy vyjádřit své postoje k očkování a důvody, které je vedly k jeho odmítání či kritice., a1_The Czech Republic and its predecessor, Czechoslovakia, have a long-term tradition of immunization programmes, with a current coverage rate of 98-99%. Vaccination is mandated by law to all individuals living in the territory of the Czech Republic. In legal terms, a person who refuses to have their child vaccinated commits an administrative offence against public health. While many experts consider immunization as one of the greatest achievements of modern medicine, some members of Czech society do not regard compulsory vaccination as a clearly positive phenomenon. This paper focuses on parents’ critical perspectives on immunization in the Czech Republic. Its goal is to present the sociodemographic characteristics of parents with critical attitudes to immunization as well as the argumentative discourses they mobilize. The text is based on a questionnaire survey of parents who are active critics of immunization practice. The questionnaire was published at the website of Rozalio, a leading NGO that mobilizes parents against the practice of compulsory vaccination in the Czech Republic. 372 respondents participated in the survey. Open-ended questions were used to invite the parents to share their attitudes on vaccination and their motivations to refuse or critique the practice. The paper starts by presenting a sociodemographic profile of the parents who participated in the questionnaire survey. The quantitative data presented are not representative and rather provide us with general hints to better understand who the parents against vaccination are. The results indicate that critical debates on the practice of compulsory vaccination are primarily attended by better-educated women living in different parts of the Czech Republic. Subsequently, the central part of the analysis deals with the respondents´ answers to open-ended questions about their motivations to refuse/postpone vaccination. Three distinct ways the parents framed their critical attitudes to vaccination were identified in the analysis. The most salient frame, „biomedical discourse of risk“, exploited the concepts and principles of biomedicine but deviated from the dominant interpretation of immunization as public good, instead emphasizing related individual risks. As opposed to the concept of collective immunity as one of the pillars of general immunization policies and epidemiologic discourses, the parents emphasized the need to take an individual approach and personalize the risk. The second frame, „discourse of holistic health“, was much less salient. Referring to the principles of holistic medicine, it emphasized the role of lifestyle at the expense of medical control of the body. Finally, „activist discourse“ was another less frequently mentioned frame. It argued against vaccination as part of a more general critique of the ways the health care system operates and government interferes with individual freedoms., Jaroslava Hasmanová Marhánková, Jitka Skálová., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

7. Recent development of biomedical research at the Institute of Physiology of the Czech Academy of Sciences in Prague

Creator:
Jan Kopecký and Josef Zicha
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, Fyziologický ústav (Akademie věd ČR), biomedicína, výzkum a vývoj, biomedicine, research and development, 14, and 612
Language:
English
Description:
J. Kopecký, J. Zicha. and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

8. Statistics in three biomedical journals

Creator:
Tomáš Pilčík
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, statistika, odborné časopisy, biomedicína, statistics, professional journals, biomedicine, usage, biomedical journals, assessment, 14, and 612
Language:
English
Description:
In this paper we analyze the use of statistics and associated problems, in three Czech biological journals in the year 2000. We investigated 23 articles Folia Biologica, 60 articles in Folia Microbiologica, and 88 articles in Physiological Research. The highest frequency of publications with statistical content have used descriptive statistics and t-test. The most usual mistake concerns the absence of reference about the used statistical software and insufficient description of the data. We have compared our results with the results of similar studies in some other medical journals. The use of important statistical methods is comparable with those used in most medical journals, the proportion of articles, in which the applied method is described insufficiently is moderately low., T. Pilčík., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

9. Trendy v regeneraci a léčbě CNS

Creator:
Eva Syková and Pavla Jendelová
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, centrální nervový systém, terapie, konference, biomedicína, central nervous system, therapy, conferences, biomedicine, Česko, Czechia, 12, and 00
Language:
Czech
Description:
Eva Syková, Pavla Jendelová.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public