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Start Over Subject cardiac ischaemia

1. Contribution to the problems of volume parameters of the left heart ventricle of patients with ischaemic heart disease

Creator:
Vosečková, A., Weisbauerová, H., and Šístek, J.
Type:
article, model:article, and TEXT
Subject:
cardiac ischaemia, ejection fraction, left ventricular volume, peak systolic ejection rate, and peak diastolic filling rate
Language:
English
Description:
The authors studied some methodological questions associated with evaluation of the X-ray of the left ventriculogram (VTG). On the basis of their results they suggest that, in addition to the usual comprehensive volume parameters of the left ventricle (EDVI, ESVI, the EF), further indices, obtained either by drawing the cardiac contour frame-by-frame (norm dV/dtmjn), or by dividing the diastole into halves or thirds (the indicies norm FF 1/2 or norm FF 1/3), should be used. These indices allow more sensitive differentiation of patients with impaired left ventricular function.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Ischaemic cardiac hyperaemia: Role of nitric oxide and other mediators

Creator:
Gryglewski, R. J., Chlopicki, S., Niezabitowski, P., Jakubowski, A., and Lomnicka, M.
Type:
article, model:article, and TEXT
Subject:
cardiac reactive hyperaemia, cardiac ischaemia, endothelium, prostacyclin, nitric oxide, and adenosine
Language:
English
Description:
In the perfused guinea-pig heart reactive hyperaemia (RH) after occlusion of coronary flow (1-60 s) was inhibited by 100-60 % with NG-nitro-L-arginine (100 /¿M) and to a lesser extent (by 35 %) after 8-phenyltheophylline (10 /¿M), but not by indomethacin (5 ,«M). Inhibition of adenosine deaminase by erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) (5 yWM) not only increased the concentration of adenosine in the coronary perfusate, but also prolonged the duration of RH. RH induced cardiac generation of prostacyclin, nitric oxide and adenosine as indicated by the appearance of 6-keto-PGFia, cyclic GMP, adenosine, inosine, hypoxanthine, xanthine and urate in the perfusate. Only NO and adenosine, but not prostacyclin, were responsible for RH. RH after short-term (1-10 s) coronary occlusion was mediated by NO, whereas adenosine and NO maintained RH that followed after longer (20 s-10 min) periods of cardiac ischaemia. Prostacyclin never participated in the mediation of RH.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public