The epidermis of the Korean spined loach Iksookimia koreensis was divided into three layers: an outermost layer, middle layer and stratum germinativum. And the dermis was composed of two layers: stratum laxum and compactum. The outermost layer consisted of polygonal cells or flattened cells, small amount mucous cells, and the middle layer consisted of two types of skin glands, a small mucous cell and a large club cell. The mucous cell was acid sulfomucins (some sialomucins), but the club cell did not show any histochemical reaction to mucosubstances. The stratum germinativum was composed of a cuboidal epithelial cell and a well-defined lymphatic space containing small lymphocytes. There was a large number of blood vessels just below the basement membrane. The stratum laxum of dermis has small scales and a definite area that was AB positive and PAS positive.