The article is devoted to the enterprise and state reactions against the impact of economic crisis on business R&D and innovation. It analyses strategic approaches and solution of enterprises during the crisis period with respect to ensuring competitiveness when the economy rebounds. There are used findings from surveys realised in the Czech Republic as well. The article is concluding with the context of general environment for business R&D by analysis of economic stimulus packages introduced by governments as measures in response to the crisis. and Karel Mráček.