In modern society, many people keep working hours different from the standard (9 hours, 5 days a week during conventional time of the day), a regimen leading to sleep deprivation and/or circadian desynchronization, and, consequently, to sleepiness, fatigue, impaired efficiency and ultimately to psychic and somatic complaints. Fortunately, sleepiness-related health and occupational hazards can be kept under control using scientifically tested precautions designed to help maintain wakefulness. Suitable work and rest scheduling and observance of the principles of sleep hygiene are of major importance there. In situations which interfere with sleep, it is possible to use hypnotics or behavioral techniques and melatonin for circadian regimen optimization. In situations when sleep loss is temporarily inevitable, options to be taken into account include work shift shortening, breaks for rest, naps of short duration or administration of vigilance enhancing drugs. In the future, risks associated with sleepiness could be mitigated by means of currently developed technologies for real-time detection of sleepiness.