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321. Acute Leukemias XV, Biology and Treatment Strategies

Creator:
Lemež, Petr
Format:
print, text, and regular print
Type:
model:article, article, Text, and TEXT
Subject:
kongresy jako téma, lidé, akutní lymfatická leukemie--farmakoterapie, akutní myeloidní leukemie--farmakoterapie, protokoly antitumorózní kombinované chemoterapie, reziduální nádor, imunoterapie--metody, receptory antigenů T-buněk--terapeutické užití, CTL019 buňky, and blinatumomab
Language:
Czech
Description:
Petr Lemež
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

322. Acyl-CoA Binding Domain Containing 3 (ACBD3) Protein in Huntington’s Disease Human Skin Fibroblasts

Creator:
Kratochvíľová, Helena, Rodinová, Marie, Sládková, Jana, Klempíř, Jiří, Lišková, Irena, Motlík, Jan, Zeman, Jiří, Hansíková, Hana, and Tesařová, Markéta
Format:
print, text, and regular print
Type:
model:article, article, Text, práce podpořená grantem, and TEXT
Subject:
lidé, dospělí, studie případů a kontrol, Huntingtonova nemoc--metabolismus, membránové proteiny--fyziologie--metabolismus, adaptorové proteiny signální transdukční--fyziologie--metabolismus, kůže--metabolismus--patologie, fibroblasty--metabolismus, buněčné linie--metabolismus, heterozygot, imunohistochemie, frakcionace buněk, lidské kožní fibroblasty, and Acyl-CoA binding domain containing 3 protein
Language:
Czech and English
Description:
Huntingtonova choroba (HD) je autozomálně dominantní neurodegenerativní onemocnění způsobené zvýšením počtu polyglutaminových repetic (> 35 repetic) v genu pro protein huntingtin. HD je charakteristická pomalými progresivními změnami pohybového aparátu a osobnosti, kdy tyto změny jsou často doprovázeny ztrátou tělesné hmotnosti. Do dnešního dne není znám přesný mechanizmus patofyziologie choroby. Poruchy pohybových funkcí reflektují masivní poškození specifických částí mozku (striatum), které bylo popsáno u pacientů s HD. V roce 2013 Sbodio et al [1] popsali zvýšené množství proteinu Acyl‑CoA binding domain containing 3 (ACBD3) ve striatu HD pacientů. Protein ACBD3 hraje nezastupitelnou roli v mnoha buněčných procesech, a to především díky interakci s různými vazebnými partnery. ACBD3 je esenciální při neuronálním dělení, neurodegeneraci, udržení lipidové homeostáze, stresové odpovědi, virové replikaci, apoptóze, udržení struktury golgiho komplexu. V této práci jsme prokázali nepřítomnost proteinu ACBD3 v mitochondriích v lidských kožních fibroblastech a navíc jsme potvrdili, že změny celkové hladiny proteinu ACBD3 ve fibroblastech HD pacientů nejsou konzistentní., Huntington’s disease (HD) is an autosomal‑dominant neurodegenerative disease caused by the expansion of polyglutamine repeats (> 35 repeats) in the nuclear gene for the huntingtin protein. HD is characterized by slow progressive changes in motor behaviour and personality that are sometimes accompanied by weight loss. To date, the exact mechanisms of HD pathophysiology have not been defined. Impaired motor behaviour reflecting massive and selective destruction of the striatum has been observed in patients with HD. Sbodio et al. [1] reported in 2013 that Acyl‑CoA binding domain containing 3 (ACBD3) protein levels were elevated in the striatum of HD patients and connected with higher neurotoxicity in HD. The ACBD3 protein plays essential roles in many different cellular functions via interactions with a multitude of partners. ACBD3 is involved in neuronal stem cell self‑renewal, neurodegeneration, lipid homeostasis, stress resistance, intracellular vesicle trafficking, organelle maintenance, viral replication and the apoptotic response. Herein, we found that ACBD3 in not present in the mitochondria in skin fibroblasts. Moreover, our findings also revealed that the total cellular level of ACBD3 is not consistent among the fibroblasts of HD patients., and H. Kratochvíľová, M. Rodinova, J. Sladkova, J. Klempir, I. Liskova, J. Motlik, J. Zeman, H. Hansíková, M. Tesarova
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

330. Adaptability of students with different individual and typological peculiarities of vegetative functions regulation

Creator:
Tananakina, Tatiana, Lila, Natalya, Ivasenko, Anzhelika, Bolgov, Dmitrij, Mavrich, Svetlana, and Modna, Yuliya
Format:
electronic, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, hodnotící studie, and TEXT
Subject:
adaptace fyziologická, autonomní nervový systém--fyziologie, fyziologické jevy, srdeční frekvence--fyziologie, časná diagnóza, hodnocení rizik, mladiství, dospělí, ženské pohlaví, lidé, mužské pohlaví, studenti, and výchova, vzdělávání
Language:
English
Description:
In the last decade the health of young people in Ukraine as well as in many other countries of the world significantly deteriorated according to the results of screening tests. Because of this the main task of prophylactic medicine is development and introduction of new methods of early diagnostics of diseases. The aim of the work to assess the peculiarities of adaptation of students with different types of vegetative regulation. Material and methods: 415 second year students of Lugansk State Medical University were tested. The mechanisms of physiological functions of the body regulation were assessed by registration of cardiac rhythm variability (CRV). Analysis of CRV was performed by three methods: statistical, geometrical, and spectral analysis. The express method proposed by Shlyk, N.I. (2009) was later used to determine the prevailing type of vegetative regulation. To assess adaptability the method of R.M. Baevskij (1979) was used. Results: In the result of investigation 4 types of functional states of regulatory systems were determined: I type 295 (71 %) of tested, II in 14 (3 %), III in 96 (23 %) and IV only in 10 (2%). I type of functional state of regulatory systems in the wakeful state at rest was characterized by moderate prevalence of central regulation of heart rhythm (MPCR), decreased activity of autonomic regulation. It was noticed that some of the parameters of CRV (like R­R, SDNN, RMSSD and pNN50) which characterize autonomic regulation, were statistically lowere (р≤0.01) compared to type III, and some (like AMo and SI) higher, in both female and male students. Summarized spectrum capacity and components of its wave structure (HF, LF, VLF) which characterize central regulation were statistically significantly lower (р≤0.01) for the I type of regulation compared to the III one which is characterized by moderate prevalence of autonomic regulation of the heart rhythm. In female students with type I autonomic regulation compared to male students such CRV parameters as R­R and AМo were statistically significantly lower (р≤0.05), while the parameters of total potency (TP) and high frequency waves (HF) were higher (р≤0.05), which could point to more centralized heart rhythm regulation in male compared to female. The evaluation of regulatory systems overstress allowed to determine the state of adaptation and risk of overstress or breakdown in students with different types of autonomic regulation. Conclusions: Thus, evaluation of adaptation state in students with different types of autonomic regulation allows to characterize the current functional state and uncover the risk of disease development., Tatiana Tananakina, Natalya Lila, Anzhelika Ivasenko, Dmitrij Bolgov, Svetlana Mavrich, Yuliya Modna, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

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