The Czech dissident movement included thinkers who searched for a morally pure, parallel polis, and who felt comfortable within its isolation. The philosophers of Charter 77 (Jan Patočka and Ladislav Hejdánek especially), by contrast, rejected the idea of being morally superior to their opponents. It is interesting to consider where Václav Havel stands at this crossroads. Havel very much cooperated with the above-mentioned philosophers and was inspired by them in his own writing and agency. On the other hand, Havel undoubtedly performed a certain moral-existential concept of dissent. In this paper I examine Havel’s existential concept. In particular, after distinguishing between two existential approaches in Havel’s writings, I analyse two fundamental philosophical critiques of Havel in the work of Ladislav Hejdánek. According to Hejdánek, Havel 1) identifies intellectuals with non-politicians, i.e. he is governed by the incorrect dualism of the political versus the non-political, and 2) is self-focused and moralising, i.e. he keeps too much within his own self (subjectivity) and “a given” (existent, objective) world. Given this critique, I will systematise Hejdánek’s objections and suggested solutions. In the first case, I see the solution in a more detailed distinction: we should distinguish between politics and non-politics (intellectuals) but also non-political politics. In the second case, we should look for the essence (focal point) of man not in his morality but outside it: man should orient himself “out of his self”.
Since Antiquity, logic has always enjoyed a status of something crucially important, because it shows us how to reason, if we are to reason correctly. Yet the twentieth century fostered an unprecedented boost in logical studies and delivered a wealth of results, most of which are not only not understandable by non-specialists, but their very connection with the original agenda of logic is far from clear. In this paper, I survey how the achievements of modern logic are construed by non-specialists and subject their construals to critical scrutiny. I argue that logic cannot be taken as a theory of the limits of our world and that its prima facie most plausible construal as a theory of reasoning is too unclear to be taken at face value. I argue that the viable construal of logic takes it to be explicative of the constitutive (rather than strategic) rules of reasoning, not of the rules that tell us how to reason, but rather of rules that make up the tools with which (or in terms of which) we reason., Od starověku se logika vždy těšila stavu něčeho zásadně důležitého, protože nám ukazuje, jak rozumět, pokud máme správně rozumět. Dvacáté století však podpořilo bezprecedentní oživení v logických studiích a přineslo mnoho výsledků, z nichž většina není nejen srozumitelná pro nešpecializované odborníky, ale jejich samotné spojení s původní logikou logiky není zdaleka jasné. V tomto příspěvku zkoumám, jak jsou úspěchy moderní logiky konstruovány nešpecializovanými odborníky a podřizují jejich konstrukty kritické kontrole. Domnívám se, že logiku nelze považovat za teorii hranic našeho světa a její prima facienejspolehlivější konstrukční jako teorie uvažování je příliš nejasná, aby mohla být přijata v nominální hodnotě. Domnívám se, že životaschopná konstrukce logiky má za to, že je vysvětlující konstitutivní (spíše než strategická) pravidla uvažování, nikoli pravidla, která nám říkají, jak rozumět, ale spíše pravidla, která tvoří nástroje, s nimiž (nebo v podmínky) rozumíme., and Jaroslav Peregrin
A number of effects which can affect the low-mass IMF derived from the local luminosity function is studied. We consider an influence of unresolved binairies, variations in fine structure of mass-luminosity relation, BC-scale, chemical composition, and evolution of brown dwarfs. The mass-luminosity relation is found to be the main factor defining the IMF. As analysis shows, different theoretical relations calculated for Pop I composition result in different IMFs /from a power law, to a lognormal one/. The presence at faintest magnitudes /Mν > 20^m/ of a large number of brown dwarfs, slowly evolving with decreasing luminosity, leads to the depletion of the luminosity function for both lognormal and power IMFs.
Epileptic afterdischarges (ADs) elicited by electrical stimulation of sensorimotor cortical area were used as a model to study the role of neurotransmitter systems in cortical seizures in three age groups of developing rats. Drugs augmenting inhibition mediated by GABAA receptors were found to suppress ADs in all age groups, their activity was usually more marked in younger than in 25-day-old rat pups. Drugs potentiating GABAB receptors exhibit lower efficacy and more complicated developmental profile than GABAA-ergic drugs. Effects of an antagonist of GABAB receptor – marked prolongation of ADs in all three age groups – suggest an important role of GABAB receptors in arrest of cortical seizures. Drugs affecting glutamate receptors exhibit variable effects, usually better expressed in older animals than in 12-day-old ones. No specific role for ionotropic as well as metabotropic glutamate receptors could be predicted. Activation of adenosinergic inhibitory modulatory system also exhibited anticonvulsant action in the present model. All three neurotransmitter systems probably participate in mechanisms of generation, maintenance and arrest of cortical seizures., P. Mareš, H. Kubová., and Obsahuje bibliografii a bibliografické odkazy
Psychostimulants, as well as cannabinoids, have been shown to
significantly affect a great variety of behaviors in both humans
and laboratory animals. Our previous studies have repeatedly
demonstrated that the application of the vehicle for
psychostimulants, i.e. saline, to control groups, generated
different behavioral test results compared to absolute naïve
controls (i.e. without any injection). Therefore, our present study
has set three goals: (1) to evaluate the effect of three different
psychostimulant drugs, (2) to evaluate the effect of three doses
of delta 9-tetrahydrocannabinol (THC), and (3) to evaluate the
effect of saline and ethanol injections vs sham injections and no
injection on spontaneous behavior of adult male rats. The
LABORAS test (Metris B.V., Netherlands) was used to examine
spontaneous locomotor activity and exploratory behavior in an
unknown environment over 1 h. In Experiment 1,
psychostimulant drugs were tested: single subcutaneous (s.c.)
injections of amphetamine (5 mg/kg), cocaine (5 mg/kg), and
3,4-methylenedioxymethamphetamine (MDMA) (5 mg/kg) were
applied prior to testing. Control animals received the same
volume (1 ml/kg) of s.c. saline. In Experiment 2, the effect of
three doses of THC (1, 2, and 5 mg/kg, s.c.) were examined.
An s.c. injection of vehicle (ethanol) was used as a control. In
Experiment 3, injections of saline and ethanol were compared to
the group receiving a sham s.c. injection and to a group of
absolute “naïve” controls. Our results demonstrated that (1) all
psychostimulants increased locomotion time, distance traveled,
and speed while decreasing immobility time of adult male rats
relative to saline controls. The most prominent effect was
associated with MDMA; (2) The effect of THC was dosedependent and was most apparent within the first 10 min of the
LABORAS test. (3) With regard to the effect of injection: absolute
controls (without injection) compared to animals injected with
ethanol, saline, or sham-injected displayed reduced immobility
time, traveled longer distances, and had increased speed. In
conclusion, our data showed drug dependent behavioral changes
in adult male rats after application of psychostimulants and
cannabinoids. Our findings also suggest that not only drugs but
the actual single injection per se also affects the behavior of
laboratory animals in an unknown environment. This effect
seems to be associated with the acute stress associated
with the injection.
The quality of stored blood can be deteriorated by hemolysis caused by free radicals. The purpose of this study was to elucidate whether neutrophile leukocytes are the source of free radicals in stored blood as in hemodialyzed patients. Resuspensions with low (LL) or high (HL) leukocyte concentrations were prepared from samples of twenty healthy volunteers. The samples were incubated for 10 days at 4 °C and then for one day at 37 °C. Markers of hemolysis and free radical metabolism were examined before and after incubation in LL and HL samples. In spite of the difference of leukocytes counts in LL and HL resuspensions (p<0.0001), the pre-incubation values of all laboratory parameters were practically identical. In post-storage samples, superoxide dismutase and glutathione peroxidase activities did not differ in either group. Reduced glutathione in erythrocytes and extracellular antioxidant capacity were insignificantly lower in HL resuspensions, but the increase of malondialdehyde was much more pronounced in the HL samples (p<0.0001). The degree of hemolysis, expressed as the extracellular increase of potassium (p<0.001), hemoglobin (p<0.05) and lactate dehydrogenase (p<0.05), was higher in the HL samples. Our results support the hypothesis that leukocytes participate in free radical production in stored blood., J. Racek, R. Herynková, V. Holeček, J. Faltysová, I. Krejčová., and Obsahuje bibliografii
The carbon dioxide concentrating system in C4 photosynthesis allows high net photosynthetic rates (PN) at low internal carbon dioxide concentrations (Ci), permitting higher PN relative to stomatal conductance (gs) than in C3 plants. This relation would be reflected in the ratio of Ci to external ambient (Ca) carbon dioxide concentration, which is often given as 0.3 or 0.4 for C4 plants. For a Ca of 360 µmol mol-1 that would mean a Ci about 110-140 µmol mol-1. Our field observations made near midday on three weedy C4 species, Amaranthus retroflexus, Echinochloa crus-galli, and Setaria faberi, and the C4 crop Sorghum bicolor indicated mean values of Ci of 183-212 µ mol mol-1 at Ca = 360 µmol mol-1. Measurements in two other C4 crop species grown with three levels of N fertilizer indicated that while midday values of Ci at high photon flux were higher at limiting N, even at high nitrogen Ci averaged 212 and 196 µmol mol-1 for Amaranthus hypochondriacus and Zea mays, respectively. In these two crops midday Ci decreased with increasing leaf to air water vapor pressure difference. Averaged over all measurement days, the mean Ci across all C4 species was 198 µmol mol-1, for a Ci/Ca ratio of 0.55. Prior measurements on four herbaceous C3 species using the same instrument indicated an average Ci/Ca ratio of 0.69. Hence midday Ci values in C4 species under field conditions may often be considerably higher and more similar to those of C3 species than expected from measurements made on plants in controlled environments. Reducing gs in C4 crops at low water vapor pressure differences could potentially improve their water use efficiency without decreasing PN.