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432. Does the treatment of primary hyperaldosteronism influence glucose tolerance?
- Creator:
- Branislav Štrauch, Jiří Widimský, Gustav Šindelka, and Jan Škrha
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, krevní tlak, blood pressure, primary hyperaldosteronism, impaired glucose tolerance, 14, and 612
- Language:
- English
- Description:
- Primary hyperaldosteronism (PH) is frequently considered to be a secondary form of diabetes mellitus (DM). In our previous study we attempted to evaluate the prevalence of DM among patients with PH compared to control subjects with essential hypertension (EH). We have noted a relatively high prevalence of DM and impaired glucose tolerance in PH, but the differences between the PH and EH groups did not reach statistical significance. We performed this study to assess whether the effective treatment of PH (surgical and conservative) would improve the glucose tolerance. We have studied 24 patients with PH of the following two subtypes: aldosterone-producing adenoma (APA) treated with adrenalectomy and idiopathic hyperaldosteronism (IHA) treated with spironolactone. No significant changes of glucose levels were found in the 60th and 120th min of the oral glucose tolerance test (OGTT) in the APA group. On the other hand, fasting glucose levels were decreased significantly after adrenalectomy. Plasma glucose levels were significantly increased in the 60th min, but no differences were found in fasting values and in the 120th min in the IHA group. There was a significantly higher incidence of impaired glucose tolerance (36 % before, 45 % after treatment) and DM (9 %, 18 %) in the IHA group compared to the APA group (8 %, 32 %; DM 0 %, 0 %). In conclusion, the treatment of PH does not improve glucose tolerance. Mild worsening of glucose tolerance after treatment could be explained by an increase of the body mass index. These data, in accordance with our previous study, do not support the idea that PH is a secondary form of diabetes mellitus., B. Štrauch, J. Widimsky Jr., G. Šindelka, J. Škrha., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
433. Does Vigabatrin Possess an Anticonvulsant Action Against Pentylenetetrazol-Induced Seizures in Developing Rats?
- Creator:
- Renata Haugvicová, Hana Kubová, and Pavel Mareš
- Format:
- print, bez média, and svazek
- Type:
- article, studie, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Vigabatrin, Pentylenetetrazol, Motor seizures, Ontogeny, Rat, 14, and 612
- Language:
- English
- Description:
- Anticonvulsant action of vigabatrin (300, 600, 900 and/or 1200 mg/kg i.p.), an inhibitor of GABA-transaminase, was studied in a model of motor sezures elicited by pentylenetetrazol. Five age groups of rats (7, 12, 18, 25 and 90 days old) received a s.c. injection of pentylenetetrazol 4, 6 and/or 24 hours after vigabatrin administration. The incidence of minimal, predominantly clonic seizures was not changed in any age group, but their latencies were prolonged in 18- and 25-day-old rats. Generalized tonic-clonic seizures were influenced in a more complex manner. Incidence of these seizures was decreased in 7-day-old rat pups 24 hours after vigabatrin administration. Higher doses of vigabatrin exhibited a similar effect in adult rats at all intervals studied. Specific suppression or at least restriction of the tonic phase was observed in all groups of immature rats, the effect was more marked 24 hours after vigabatrin than at shorter intervals. The anticonvulsant action of vigabatrin, which could be demonstrated mainly against generalized tonic-clonic seizures, varies markedly during development., R. Haugvicová, H. Kubová, P. Mareš., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
434. Dojmy pocestné
- Creator:
- Thomayer, Josef
- Publisher:
- Unie
- Format:
- print and 151, i s.
- Type:
- model:monograph and TEXT
- Subject:
- Lékařské vědy. Lékařství, lékařství, cestování, 14, and 61
- Language:
- Czech
- Description:
- Josef Thomayer. and Desky nejsou k dispozici, použity desky z MVS.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
435. Domácí lékárna pro případy náhlého onemocnění
- Creator:
- Lad Šír
- Publisher:
- Tisk a náklad Antonína Čapka
- Format:
- print, text, regular print, and 99 s., 1 vlepený l. ; 15 cm
- Type:
- model:monograph and TEXT
- Subject:
- Fyzioterapie. Psychoterapie. Alternativní lékařství, alternativní terapie, lidové léčitelství, nemoci, 615.8, 615.89, 616.1/.9, (035), and 14
- Language:
- Czech
- Description:
- ve prospěch obecného lidu podává Lad. Šír
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
436. Dopamine 2 and somatostatin 1-5 receptors coexpression in clinically non-functioning pituitar adenomas
- Creator:
- Filip Gabalec, Drastikova, M., Tomáš Česák, David Netuka, Václav Masopust, Josef Machač, Josef Marek, Jan Čáp, and Michal Beránek
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, dopaminové receptory, adenomy hypofýzy, imunohistochemie, dopamine receptors, pituitary adenomas, immunohistochemistry, somatostatin receptor, estrogen receptor, clinically non-functioning adenomas, real-time PCR, 14, and 612
- Language:
- English
- Description:
- This study investigated quantitated expression of dopamine 2 receptor (D2R) and somatostatin receptors of the five types (SSTR1-SSTR5) in a large series of clinically non-functioning pituitary adenomas (CNFAs). Co-expression of these receptors in individual adenomas was studied as well as correlation between receptor types. Adenoma tissue from 198 patients who underwent surgery for CNFAs was analyzed by immunohistochemistry and quantitative real-time PCR. D2R and SSTR1-3 mRNA was expressed in all 198 adenomas. SSTR4 and SSTR5 were detectable in 85 % and 61 % of adenomas, respectively. Expression of D2R was significantly higher than that of the somatostatin receptors. The median relative expressions were as follows from highest D2R >> SSTR3 > SSTR2 > SSTR1 > SSTR5 > SSTR4. High relative expression (ratio to β-glucuronidase mRNA > 1) of D2R was found in 60 % of tumors, high expression of SSTR1 in 7.5 %, SSTR2 in 7 %, SSTR3 in 4 % and SSTR5 in 0.5 %. The quantity of D2R correlated positively with expression of SSTR2 and SSTR3, and negatively with SSTR1 and SSTR5. Among histological adenoma types, SSTR1 was significantly higher in null-cell adenomas and SSTR3 was lower in silent corticotroph adenomas. In conclusions, in CNFAs, high expression of somatostatin receptors is much less common than that of D2R, and co-expression of both these receptors is exceptional. D2R and SSTR3 seem to be the most promising targets for pharmacological treatment., F. Gabalec, M. Drastikova, T. Cesak, D. Netuka, V. Masopust, J. Machac, J. marek, J. Cap, M. Beranek., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
437. Dorsal rhizotomy changes the spontaneous neuronal activity of nuclei in the medial thalamus
- Creator:
- Šimon Vaculín, Miloslav Franěk, and Richard Rokyta
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, deafferentation, medial thalamus, single neuronal unit activity, 14, and 612
- Language:
- English
- Description:
- The aim of this study was to examine the influence of unilateral dorsal root section at the cervicothoracic level of the spinal cord on the spontaneous neuronal activity of medial thalamic nuclei in the rat. Single unit extracellular recordings from thalamic nuclei, nc. parafascicularis and nc. centralis lateralis, were obtained with glass micropipettes. The abnormal bursting activity of these nuclei following deafferentation was registered, although a correlation between the occurrence of this activity and the degree of autotomy behavior was not found. Such bursts were never observed in the studied thalamic nuclei of control rats., Š. Vaculín, M. Franěk, R. Rokyta., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
438. Drug carriers with star polymer structures
- Creator:
- Kotrchová, L, Kostka, L, and Tomáš Etrych
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- léčiva, polymery, pharmaceuticals, polymers, water-soluble polymers, drug carriers, star polymers, hyperbranched polymers, 14, and 612
- Language:
- English
- Description:
- In this review we summarize several synthetic approaches to the advanced synthesis of star-like polymer-based drug carriers. Moreover, their application as nanomedicines for therapy or the diagnosis of neoplastic diseases and their biodistribution are reviewed in detail. From a broad spectrum of star-like systems, we focus only on fully water-soluble systems, mainly based on poly(ethylene glycol) or N-(2-hydroxypropyl)methacrylamide polymer and copolymer arms and polyamidoamine dendrimers serving as the core of the star-like systems., L. Kotrchová, L. Kostka, T. Etrych., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
439. Dual role of thyroid hormones in rat soleus muscle MyHC isoform expression
- Creator:
- Vadászová-Soukup, A. and Tomáš Soukup
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, hormony štítné žlázy, potkan, physiology, thyroid hormones, Rattus norvegicus, soleus muscle, myosin heavy chains, SDS-PAGE, RT-PCR, 14, and 612
- Language:
- English
- Description:
- We have analyzed the influence of altered thyroid hormone levels on changes of MyHC protein isoforms and their mRNA transcripts in the soleus muscle of 2-, 4- and 7-month-old euthyroid (EU), hypothyroid (HY) and hyperthyroid (TH) female inbred Lewis strain rats (methimazole and T3 treatment started 3 to 4 weeks after birth). We have found that the content of the dominant MyHC 1 isoform gradually increased in the EU rats and that this increase was more progressive in the HY rats at all three stages. On the other hand, in the TH rats the content of MyHC 1 isoform was the highest in the 2-month-old rats and it decreased with an increasing length of T3 treatment. The content of the minor 2a MyHC isoform followed the opposite pattern. In contrast to the protein isoforms, the MyHC mRNA transcripts remained at similar levels. Nevertheless, in general, the MyHC 1 mRNA level was decreased and MyHC 2a transcript increased in the TH rats, while the opposite changes occurred in the HY rats. Our results thus suggest that in the rat soleus muscle, both increased and decreased levels of thyroid hormones speed up the formation of an adult slow phenotype which is demonstrated by the precocious appearance of the slow MyHC 1 isoform, but opposite to the hypothyroid status, a longer T3 application promotes the expression of the faster MyHC 2a isoform., A. Vadászová-Soukup, T. Soukup., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
440. Dva deníky Dra. Matiáše Borbonia z Borbenheimu
- Creator:
- Matyáš Borbonius z Borbenheimu, Max Dvořák, and Česká akademie císaře Františka Josefa pro vědy, slovesnost a umění
- Publisher:
- Česká akademie císaře Františka Josefa pro vědy, slovesnost a umění
- Format:
- print and vi, 165 s.
- Type:
- text, volume, autobiografie, deníky, model:monograph, and TEXT
- Subject:
- Biografie, Lékařské vědy. Lékařství, Borbonius z Borbenheimu, Matyáš, 1566-1629, 16.-17. stol, lékaři, Česko, 929, 616-051, (437.3), (092), (093.3), 8, 14, and 61
- Language:
- Latin and Czech
- Description:
- 9, vydal Max Dvořák., KČSN, and Přívazek k : 1. přívazek k : Soudní akta konsistoře Pražské / Ferdinand Tadra
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public