The Human Frontier Science Program (HFSP) promotes fundamental research in the life sciences with special emphasis on novel and interdisciplinary research, international and in particular intercontintental collaboration and support for young investigators. One of the mechanisms of research support is the Young Investigator Grants Program. Vladimír Sychrovský from Institute of Organic Chemistry and Biochemistry AS CR obtained that grant for his project Probing the mechanism of the cleavage reaction in catalytic RNAs and will cooperate with scientists from Japan and USA. and Libuše Marková.
The effects of combined administration of two drugs elevating extracellular adenosine, namely dipyridamole (DP) and adenosine monophosphate (AMP), and granulocyte colony-stimulating factor (G-CSF) on hemopoietic stem cells in vivo were investigated. The experiments were performed on mice using the endogenous spleen colony formation in gamma-irradiated animals as an endpoint. The results have shown that DP and AMP act additively with G-CSF to enhance spleen colony formation and thus the erythroid repopulation of the spleen. These findings indicate that the signaling pathways of G-CSF and drugs elevating extracellular adenosine can interact at the level of primitive hemopoietic stem cells. The enhancement of hemopoiesis-stimulating effects of G-CSF by DP and AMP, which are low-priced and clinically available drugs, could improve the cost-effectiveness of the therapy with G-CSF., M. Hofer, M. Pospíšil, J. Netíková, V. Znojil, J. Vácha., and Obsahuje bibliografii
We consider a convexity notion for complex spaces X with respect to a holomorphic line bundle L over X. This definition has been introduced by Grauert and, when L is analytically trivial, we recover the standard holomorphic convexity. In this circle of ideas, we prove the counterpart of the classical Remmert’s reduction result for holomorphically convex spaces. In the same vein, we show that if H0(X,L) separates each point of X, then X can be realized as a Riemann domain over the complex projective space Pn, where n is the complex dimension of X and L is the pull-back of O(1)., Viorel Vâjâitu., and Obsahuje seznam literatury
Archaeological sources provide a wide range of information to help understand the social structure of human society in the past. In this paper, the authors deal with the information potential of grave pit modifi cations and wooden structures in graves at burial sites in the central region of Great Moravia (southeast Moravia, southwest Slovakia). The goal at this point is to defi ne the basic hypotheses and describe the methodological basis along with the research methodology. The authors treat the sources holistically, which means that one of the methodological foundations is the claim that the properties of the whole are not a simple sum of its parts. This means that all recognized elements of the funeral rite and their mutual relations and functions are the center of attention of this research. The primary basis for the research is the assumption that the presence of various wooden structures or wooden burial receptacles in the graves of the Great Moravian period is a common cultural occurrence. It further tests the hypothesis that there was intent behind choosing of these different wooden structures and grave pit modifi cations and their usage, as well as a potential differentiation based on age or gender in the frequency, quality and selection of these modifi cations/arrangements and structures. The main methodological tools are statistical and GIS analysis and the results are compared with published fi ndings from the wider Central European region., Marian Mazuch, Marek Hladík., and Obsahuje seznam literatury
Gravitační síly jsou nejslabší ze čtyř fundamentálních fyzikálních interakcí, a přesto jsou to ony, které určují makrostrukturu galaxií, hvězd i planety Země. Úkolem gravimetrie je měření a systematické studium zemského tíhového pole, které významně ovlivňuje řadu procesů v zemském tělese, na zemském povrchu i v atmosféře. V užité gravimetrii zkoumáme tíhová pole Země za účelem vymezení hustotních nehomogenit v zemské kůře. V geodézii jsou výsledky tíhových měření využívány k určení geoidu, což je plocha konstantního tíhového potenciálu, která splývá s klidnou hladinou světových oceánů [1, 2]., Jan Švancara., and Obsahuje seznam literatury