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6594. Fiber product preserving bundle functors as modified vertical Weil functors

Creator:
Mikulski , Włodzimierz M.
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
matematika, mathematics, Weil algebra, Weil functor, vertical Weil functor, Weil algebra bundle functor, modified Weil functor, modified vertical Weil functor, bundle functor, fiber product preserving bundle functor, natural transformation, 13, and 51
Language:
English
Description:
We introduce the concept of modified vertical Weil functors on the category \mathcal{F}\mathcal{M}_m of fibred manifolds with m-dimensional bases and their fibred maps with embeddings as base maps. Then we describe all fiber product preserving bundle functors on \mathcal{F}\mathcal{M}_m in terms of modified vertical Weil functors. The construction of modified vertical Weil functors is an (almost direct) generalization of the usual vertical Weil functor. Namely, in the construction of the usual vertical Weil functors, we replace the usual Weil functors T^{a} corresponding to Weil algebras A by the so called modified Weil functors T^{a} corresponding to Weil algebra bundle functors A on the category \mathcal{F}\mathcal{M}_m of m-dimensional manifolds and their embeddings., Włodzimierz M. Mikulski., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

6595. Fiber type composition of unoperated rat soleus and extensor digitorum longus muscles after unilateral isotransplantation of a foreign muscle in long-term experiments

Creator:
Tomáš Soukup, Smerdu, V., and Gisela Zachařová
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, imunohistochemie, svaly, transplantace, chirurgické operace, immunohistochemistry, muscles, transplantation, surgical procedures, muscle fiber types, mATPase and immunohistochemistry, myosin heavy chains, 14, and 612
Language:
English
Description:
We examined the effects of the unilateral heterochronous isotransplantation on the fiber type composition and myosin heavy chain (MyHC) isoform content of unoperated slow soleus and fast extensor digitorum longus muscles of female inbred Lewis strain rats. Comparison was made between “control” unoperated muscles of experimental rats (after intramuscular transplantation surgery) with the corresponding muscles of completely naive (unoperated) rats of three age groups (5-, 8- and 14-month-old). This was done in order to ascertain whether these muscles can be used as reliable controls to the transplanted and host muscles for our ongoing grafting experiments. The fiber type composition was determined by assessing the histochemical reaction for myofibrillar adenosine triphosphatase, the MyHC isoform content was determined immunocytochemically using monoclonal antibodies specific to different MyHC isoforms and by sodium dodecyl sulphate polyacrylamide gel electrophoresis. Our experiments show that the heterochronous intramuscular isotransplantation procedure had no significant effect on the fiber type composition and MyHC isoform content of the “control” unoperated muscles of the experimental rats when compared to the corresponding muscles of the naive animals. Furthermore, the duration and type of isotransplantation did not also lead to differences among corresponding “control” muscles of experimental animals. We conclude that the unoperated muscles of the experimental rats can be used as controls in our current transplantation project dealing with long-term grafting experiments., T. Soukup, V. Smerdu, G. Zachařová., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

6596. Fibroblast growth factor 21: A novel metabolic regulator with potential therapeutic properties in obesity/type 2 diabetes mellitus

Creator:
Ivana Dostálová, Denisa Haluzíková, and Martin Haluzík
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, růstové faktory, obezita, půst, physiology, growth factors, obesity, fast, fibroblast growth factor 21, type 2 diabetes, peroxisome proliferator-activated receptor, glucose uptake, 14, and 612
Language:
English
Description:
Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator produced primarily by the liver that exerts potent antidiabetic and lipid-lowering effects in animal models of obesity and type 2 diabetes mellitus. This hormone contributes to body weight regulation and is strongly involved in the response to nutritional deprivation and ketogenic state in mice. The principal sites of metabolic actions of FGF21 are adipose tissue, liver and pancreas. Experimental studies have shown marked improvements in diabetes compensation and dyslipidemia after FGF21 administration in diabetic mice and primates. Positive metabolic actions of FGF21 without the presence of apparent side effects make this factor a hot candidate to treat type 2 diabetes and accompanying metabolic diseases. The aim of this review is to summarize the current knowledge about the metabolic effects of FGF21 including some preliminary data on changes of its levels in humans with a special emphasis on its therapeutic potential in type 2 diabetes mellitus., I. Dostálová, D. Haluzíková, M. Haluzík., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

6597. Field and laboratory studies on drought tolerance and water balance in adult Pergalumna nervosa (Acari: Oribatida: Galumnidae)

Creator:
Slotsbo, Stine, Sørensen, Jesper G., Josef Starý, and Holmstrup, Martin
Format:
print, počítač, and online zdroj
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Zoologie, pancířníci, ztráty vody, propustnost materiálů, přežití, Oribatida, water losses, permeability, survival, Galumnidae, oribatid mites, drought, soil water potential, osmolality, desiccation tolerance, 2, and 59
Language:
English
Description:
We studied the water balance, body fluid osmolality and survival of the oribatid mite, Pergalumna nervosa, when exposed to drought in field and laboratory experiments. In a replicated field experiment we artificially lowered the soil water content by putting roofs over selected plots, which reduced soil water potential to levels well below the permanent wilting percentage for plants (i.e. below -1.5 MPa). Even though a slight decrease in the abundance of P. nervosa (only found in the 0-5 cm soil layer) was recorded during the most severe drought stress (ca. -3.5 MPa), the majority of adult mites clearly survived these conditions for 3 weeks in the field without migrating to deeper soil layers. Exposing field collected adults in laboratory experiments simulating even more severe drought conditions revealed that P. nervosa can survive several weeks of gradually increasing drought stress (down to -7 MPa) with moderate water loss. The osmolality of body fluids increased as dehydration progressed, but apparently as a result of simple up-concentration of solutes and not the de novo synthesis of protective osmolytes. We compare and discuss these results in the light of what is known about other arthropods., Stine Slotsbo, Jesper G. Sørensen, Josef Stary, Martin Holmstrup., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

6598. Field comparison of seismic sources for high resolution shallow seismic reflection profiling on the Ljubljana Moor (Central Slovenia)

Creator:
Atanackov, Jure and Gosar, Andrej
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Geologie. Meteorologie. Klimatologie, seizmicita, seismicity, high-resolution shallow, seismic reflection, seismic source comparison, seismic source characteristics, seismic shotgun, accelerated weight dropper, 7, and 551
Language:
English
Description:
Two seismic sources were tested on different surfaces during acquisition of a 5.5-km long high resolution seismic reflection (HRS) profile on the Ljubljana Moor in central Slovenia. Maximum target depth range of the survey was 200 - 300 m. Nine different combinations of source-surface conditions were analysed. Seismic sources included a seismic shotgun and an accelerated weight dropper system. The HRS profile crossed different surfaces including: paved roads, gravel roads, ploughed fields, grasslands and marshlands. Seismic source performance on different surfaces was evaluated through frequency and S/N ratio analyses of seismic data, and analysis of source-generated coherent noise appearance on seismograms. Results show that both seismic sources are suitable for some of the surfaces found in the surveyed area. The accelerated weight dropper produced the best results on gravel road surface, but poor results were found on grassland and ploughed fields. The seismic shotgun produced the best results in water-saturated soil on marshlands. It performed less favourably in unsaturated soil, generating more coherent noise. Water-saturated marshland surface and gravel road surfaces were found to be the most favourable for acquisition of high-resolution seismic reflection data on the Ljubljana Moor., Jure Atanackov and Andrej Gosar., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

6599. Field observations, laboratory rearing and descriptions of immatures of the planthopper Hyalesthes absoletus (Hemiptera: Cixiidae)

Creator:
Sforza, Bourgoin, Thierry, Wilson, Stephen W., and Boudon-Padieu, Elisabeth
Format:
print, text, and regular print
Type:
article, bibliography, model:article, and TEXT
Subject:
zoologie, entomologie, hmyz, Hemiptera, Cixiidae, Hyalesthes absoletus, stadium infarktu, morfologie, řádkovací elektronová mikroskopie, 595.2/.7, and 5915
Language:
English
Description:
The cixiid planthopper Hyalesthes obsoletus Signoret is an efficient vector of the stolbur phytoplasma, the cause of various crop diseases. In the field, this monovoltine species feeds on a wide variety of woody and herbaceous plants. It overwinters as larvae on the roots of its host plants. During this study, we collected adults mainly from lavender (Lavendula angustifolia Miller), bindweed (Convolvulus arvensis L. and C. sepium L.), hoary cress (Cardaria draba L.), and occasionally from plantain (Plantago cynops L.), toadflax (Linaria striata L.), bedstraw (Galium verum L.), and mountain savory (Satureia montana L.). Fertility of field collected females from sites at two different elevations differed significantly. Fertility at 300 m (50.6 eggs per female; N = 28) was more than twice that at 900 m (22.8 eggs per female; N = 19). Only one specimen of the species was found to be parasitized by an undetermined species of Dryinidae (Hymenoptera). H. obsoletus was reared in controlled conditions on lavender. Unlike in the field, larvae developed in the laboratory at the base of the host plant and on basal shoots. Egg incubation averaged 7 ± 1.2 weeks (N = 10). Total development time from egg to adult averaged 27 ± 4 weeks (N = 5) on lavender. A morphological description of the five instars is provided. The study was supplemented by scanning electron microscopy. Particular attention was paid to the structure of the wax-plates and the absence of compound eyes in the early larval stages., René Sforza, Thierry Bourgoin, Stephen W. Wilson, Elisabeth Boudon-Padieu, and Lit
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

6600. Fifteen years of single center experience with stem cell transplantation for multiple myeloma: a retrospective analysis

Creator:
Radocha, Jakub, Maisnar, Vladimír, Zavřelová, Alžběta, Cermanová, Melanie, Lánská, Miriam, Kmoníček, Miloslav, Jebavý, Ladislav, Bláha, Milan, Malý, Jaroslav, and Žák, Pavel
Format:
print, text, and regular print
Type:
model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT
Subject:
dospělí, staří, přežití po terapii bez příznaků nemoci, ženské pohlaví, lidé, mužské pohlaví, lidé středního věku, mnohočetný myelom--mortalita--patologie--terapie, retrospektivní studie, transplantace kmenových buněk, přežívající - četnost, and výsledek terapie
Language:
English
Description:
INTRODUCTION: Autologous stem cell transplantation (ASCT) became standard of care for patients with multiple myeloma (MM) under the age of 65 years. We routinely perform ASCT for newly diagnosed MM since 1996 in our department. PATIENTS AND METHODS: We retrospectively analyzed all 285 transplants in 185 patients done for MM from January 1996 till December 2010. We analyzed overall survival (OS) and progression-free survival (PFS) regarding conditioning, stage, complete or very good partial remission (CR, VGPR) achievement, renal impairment, single vs. double transplant. RESULTS: Estimated 10-years survival of the whole set of patients is 39% (median survival 95 months). Patients with renal impairment show same OS as those without (p = 0.22). Patients show similar overall survival and event free survival regardless of type of transplant. We observed better outcome in terms of overall survival in patients treated with new drugs (p = 0.0014). Reaching CR or VGPR was not translated into better OS (p = 0.30) and EFS (p = 0.10). Also stage of the disease and whether single or double transplant was used did not make any significant difference in the outcome. CONCLUSION: Stem cell transplantation greatly improved outcome of patients with MM. Poor outcome of allogeneic transplantation in our group of patients is related to high transplant related mortality (20% vs. 0%) and unexpected high relapse rate. There is a trend towards better survival, when new drugs are incorporated at any time in the course of the disease. This fact supports hypothesis that use of these drugs with ASCT should translate into better long-term outcome. and J. Radocha, V. Maisnar, A. Zavrelová, M. Cermanová, M. Lánská, M. Kmonícek, L. Jebavý, M. Bláha, J. Malý, P. Zák
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

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