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8352. Incolatus et investitura medico-academica, in aula Carolina publice collata, sive, Promotio doctoralis
- Creator:
- Šamský, Alexandr Antonín Ignác and Löw z Erlsfeldu, Jan František
- Publisher:
- Typis Barbarae Franciscae Beringerin. Per Mathiam Seissenhoffer
- Format:
- 1-60, print, and [10], 58 : il. ; 15 cm
- Type:
- model:monograph, monograph, Text, vzácné tisky, vysokoškolské kvalifikační práce, and TEXT
- Subject:
- lékařství and 61
- Language:
- Latin
- Description:
- ...Alexandri Ignatii Schamsky ; [promotore ... Joanne Francisco Löw], Na předním přídeští je fialové hranaté razítko Ústav pro zdravotnickou dokumentaci, Vazba je zhotovena z ozdobného škrobového papíru V roce 2001 byla kniha restaurována Kateřinou Opatovou (dezinfekce, oprava) Kniha je uložena v ochranném pouzdře, and Restaurování Desinfekce, oprava 2001 Kateřina Opatová
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
8353. Increase of intracellular BAFF in B cells of Sjögren's patients is not affected by decrease of BAFFR
- Creator:
- Krejsek, Jan, Koláčková, Martina, Lindrová, I., Slezák, Radovan, and Andrýs, Ctirad
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT
- Subject:
- faktor aktivující B-buňky--biosyntéza--krev, receptor faktoru aktivujícího B-buňky--biosyntéza, B-lymfocyty--metabolismus, ženské pohlaví, lidé, intracelulární tekutina, intracelulární membrány, mužské pohlaví, lidé středního věku, monocyty--metabolismus, and Sjoegrenův syndrom--metabolismus
- Language:
- English
- Description:
- The presence of a broad spectrum of autoantibodies in Sjögren's syndrome (SjS) patients is the result of abnormal B-cell regulation that can be at least partially explained by abnormal BAFF/BAFFR regulation. The objective of this study was to determine both membrane and intracellular expression of BAFF/BAFFR in monocytes and B-cells in peripheral blood of 19 primary Sjögren's syndrome patients and 20 healthy controls using flow cytometry. We also measured sBAFF in serum. Compared to healthy controls, both surface and intracellular expression of BAFF was significantly increased in monocytes and B-cells of SjS patients. Also serum sBAFF level was elevated. Expression of BAFFR on B-cells of SjS patients was surprisingly decreased, but there was no clear increase or decrease within monocytes. Our results indicate that activated monocytes communicate with B-cells via BAFF and BAFFR, so that B-cells are stimulated, but BAFF is also produced to stimulate cells in autocrine way. The decrease of BAFFR expression in SjS patients suggests that there is the mechanism that attempts to take over in order to balance the high level of BAFF. and J. Krejsek, M. Koláčková, I. Lindrová, R. Slezák, C. Andrýs
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
8354. Increase of nocturnal melatonin levels in hemodialyzed patients after parathyroidectomy - a pilot study
- Creator:
- Radmila Kancheva, Sylvie Sulková, František Švára, Martin Hill, Kanchev, L., and Ivana Žofková
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, endokrinologie, melatonin, hemodialýza, hyperparatyreóza, endocrinology, hemodialysis, hyperparathyreosis, parathyroidectomy, 14, and 612
- Language:
- English
- Description:
- In hemodialyzed patients hormonal disturbances are known to occur. However, melatonin levels have not been completely studied. The aim of the study was to find whether changes in calcaemia affect melatonin secretion. For this reason we followed the nocturnal serum concentrations of melatonin and parathyroid hormone (PTH) in 9 hemodialyzed patients (6 women and 3 men, aged 37-65 years) both before and 1-3 months after parathyroidectomy at 6 p.m., 9 p.m., 11 p.m., 2 a.m., 5 a.m. and 7 a.m. At 6 p.m. blood samples to evaluate the levels of calcium and phosphate were also collected. Parathyroidectomy resulted in an increase in nocturnal melatonin levels. As expected, the parathyroidectomy was followed by considerable PTH decrease. PTH showed no nocturnal variation before or after parathyroidectomy. Calcium levels significantly decreased after the operation while phosphate levels increased. In summary, in hemodialyzed patients with hyperparathyroidism, parathyroidectomy significantly increases the nocturnal secretion of melatonin. Relationships between the pineal gland and parathyroid glands have yet to be elucidated., R. Kancheva, S. Sulková, F. Švára, M. Hill, L. Kanchev, I. Žofková., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
8355. Increased angiotensinogen production in epicardial adipose tissue during cardiac surgery: possible role in a postoperative insulin resistance
- Creator:
- Tomáš Roubíček, Markéta Dolinková, Jan Bláha, Denisa Haluzíková, Lenka Bošanská, Miloš Mráz, Jaromír Křemen, and Martin Haluzík
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, kardiochirurgie, inzulinová rezistence, physiology, cardiac surgery, insulin resistance, adiponectin, adipose tissue, angiotensinogen, critical illness, renin-angiotensin system, 14, and 612
- Language:
- English
- Description:
- Critical illness induces among other events production of proinflammatory cytokines that in turn interfere with insulin signaling cascade and induce insulin resistance on a postreceptor level. Recently, local renin-angiotensin system of adipose tissue has been suggested as a possible contributor to the development of insulin resistance in patients with obesity. The aim of our study was to determine local changes of the renin-angiotensin system of subcutaneous and epicardial adipose tissue during a major cardiac surgery, which may serve as a model of an acute stress potentially affecting endocrine function of adipose tissue. Ten patients undergoing elective cardiac surgery were included into the study. Blood samples and samples of subcutaneous and epicardial adipose tissue were collected at the beginning and at the end of the surgery. Blood glucose, serum insulin and adiponectin levels were measured and mRNA for angiotensinogen, angiotensin-converting enzyme and angiotensin II type 1 receptor were determined in adipose tissue samples using RT PCR. Cardiac surgery significantly increased both insulin and blood glucose levels suggesting the development of insulin resistance, while serum adiponectin levels did not change. Expression of angiotensinogen mRNA significantly increased in epicardial adipose tissue at the end of surgery relative to baseline but remained unchanged in subcutaneous adipose tissue. Fat expression of angiotensin-converting enzyme and type 1 receptor for angiotensin II were not affected by surgery. Our study suggests that increased angiotensinogen production in epicardial adipose tissue may contribute to the development of postoperative insulin resistance., T. Roubíček, M. Dolinková, J. Bláha, D. Haluzíková, L. Bošanská, M. Mráz, J. Křemen, M. Haluzík., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
8356. Increased circulating and epicardial adipose tissue mRNA expression of fibroblast growth factor-21 after cardiac surgery: possible role in postoperative inflammatory response and insulin resistance
- Creator:
- Tomáš Kotulák, Drápalová, J., Petr Kopecký, Zdeňka Lacinová, Kramář, P., Hynek Říha, Ivan Netuka, Malý, J., Daniel Housa, Jan Bláha, Štěpán Svačina, and Martin Haluzík
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, kardiochirurgie, inzulinová rezistence, cardiac surgery, insulin resistance, fibroblast growth factor-21, adipose tissue, skeletal muscle, 14, and 612
- Language:
- English
- Description:
- We studied the changes in seru m fibroblast growth factor-21 (FGF-21) concentrations, its mR NA, and protein expression in skeletal muscle and adipose tissue of 15 patients undergoing cardiac surgery. Blood samples were obtained: prior to initiation of anesthesia, prior to the start of extracorporeal circulation, upon completion of the surger y, and 6, 24, 48, and 96 hours after the end of the surgery. Tissue sampling was performed at the start and end of surgery. The mean baseline serum FGF-21 concentration was 63.1 (43.03-113. 95) pg/ml and it increased during surgery with peak 6 ho urs after its end [385.5 (274.55-761.65) pg/ml, p<0.001], and return ed to baseline value [41.4 (29.15-142.83) pg/ml] 96 hours afte r the end of the surgery. Serum glucose, insulin, CRP, IL-6, IL-8, MCP-1, and TNF-alpha concentrations significantly increased during the surgery. Baseline FGF-21 mRNA expression in skeletal muscle was higher than in both adipose tissue depots and it was not affected by the surgery. Epicardial fat FGF-21 mRNA increased after surgery. Muscle FGF-21 mRNA positively correlated with blood glucose levels at the end of the surgery. Our data suggest a possible role of FGF-21 in the regulation of glucose metabolism and insulin sensitivity in surgery-related stress., T. Kotulák ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
8357. Increased diameter and enhanced myogenic response of saphenous vein induced by two-week experimental orthostasis are reversible
- Creator:
- Raffai, G., Lódi, C., Illyés, G., Nádasy, G., and Monos, E.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, endotel, hladké svaly, physiology, endothelium, smooth muscles, head-up tilt, saphenous vein, vascular responses, 14, and 612
- Language:
- English
- Description:
- Previously, increased diameter and enhanced myogenic tone were seen after 2-week 45º head-up (HUT2) in the rat. We studied the reversibility and the effect of extended tilt on this phenomenon using two experimental groups: HUT2 plus 2-week horizontal (HUT2HOR2), and 4-week tilting (HUT4). 4-weeks in normal cages (NC4) served as control. Diameter of saphenous vein (SV) in 2-20 mm Hg pressure range, wall and media thickness, endothelial and smooth muscle cell densities, and cell proliferation were measured. The diameter of SV from HUT4 was significantly larger compared with HUT2HOR2 or NC4 within the whole pressure range both in Krebs-Ringer (870.4±21.3 vs. 778.2±24.9 and 771.6±28.1 μm at 10 mm Hg, respectively) and in Ca2+-free solution. Myogenic and norepinephrine-induced vascular tone, wall and media thickness did not differ among the three groups. Endothelial cell density decreased in HUT4 (10.7±1.2) vs. HUT2HOR2 (15.1±1.0) and NC4 (15.3±0.6), while that of smooth muscle was unchanged. No cell proliferation marker was seen. In conclusion, both increased diameter and enhanced myogenic tone of SV seen in HUT2 proved to be reversible. HUT4 resulted in increased SV diameter, similarly to HUT2, however, vascular tone was not amplified. This suggests that a prolonged orthostatic load may readjust the function of smooth muscle., G. Raffai, C. Lódi, G. Illyés, G. Nádasy, E. Monos., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
8358. Increased endothelin-1-mediated vasoconstrictor tone in human obesity: effects of gut hormones
- Creator:
- Schinzari, F., Tesauro, M., and Cardillo, C.
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- fyziologie člověka, human physiology, Obesity, Vascular dysfunction, Endothelin-1, Insulin resistance, Gut hormones, 14, and 612
- Language:
- English
- Description:
- The heavy impact of obesity on the development and progression of cardiovascular disease has sparked sustained efforts to uncover the mechanisms linking excess adiposity to vascular dysfunction. Impaired vasodilator reactivity has been recognized as an early hemodynamic abnormality in obese patients, but also increased vasoconstrictor tone importantly contributes to their vascular damage. In particular, upregulation of the endothelin (ET)-1 system, consistently reported in these patients, might accelerate atherosclerosis and its complication, given the pro-inflammatory and mitogenic properties of ET-1. In recent years, a number of gut hormones, in addition to their role as modulators of food intake, energy balance, glucose and lipid metabolism, and insulin secretion and action, have demonstrated favorable vascular actions. They increase the bioavailability of vasodilator mediators like nitric oxide, but they have also been shown to inhibit the ET-1 system. These features make gut hormones promising tools for targeting both the metabolic and cardiovascular complications of obesity, a view supported by recent large-scale clinical trials indicating that novel drugs for type 2 diabetes with cardiovascular potential may translate into clinically significant advantages. Therefore, there is real hope that better understanding of the properties of gut-derived substances might provide more effective therapies for the obesity-related cardiometabolic syndrome., F. Schinzari, M. Tesauro, C. Cardillo., and Seznam literatury
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
8359. Increased expression of erythropoietin receptor in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced parkinsonian model
- Creator:
- Wu, Y., Sun, X., Feng, X., Liu, R., Huang, L., Shang, Y., Liang, Z., Chen, J., Qiao, X., Liu, C., and Sun, S.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, Parkinsonova nemoc, Parkinson's disease, EPOR, MPTP, C57BL/6 mice, ventral mesencephalon, 14, and 612
- Language:
- English
- Description:
- Erythropoietin (EPO), known for its role in erythroid differentiation, has been suggested to have a direct protective role against a variety of neurotoxic insults. In the present study, we investigated the expression of EPO receptor (EPOR) and the number of EPORpositive cells in three encephalic regions (ventral mesencephalon, striatum, cortex) following lesion induced by 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP). C57BL/6 mice underwent intraperitoneal injection of MPTP at 24 h intervals for 5 days, and their brains were examined 1, 2, 4, 7, 14 or 21 days after the last injection. Western blot and immunohistochemistry analysis revealed that EPOR was dramatically up-regulated in the ventral mesencephalon, 4 days after MPTP insult until the day 21. In contrast, there was a baseline level of EPOR in the striatum and cortex. At subsequent time points after MPTP injury, the levels of EPOR in the two regions were not statistically different compared with those in normal animals. These results suggest that the regional specific up-regulation of EPOR at an early stage after MPTP stimulus may represent a pro-survival mechanism against neurotoxin injury in Parkinsonian model., Y. Wu ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
8360. Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain
- Creator:
- Michaela Procházková, Peter Zanvit, Tomáš Doležal, Ludmila Prokešová, and Miloslav Kršiak
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, bolest, artritida, cyklooxygenáza 2, mícha, pain, arthritis, cyclooxygenase 2, spinal cord, 14, and 612
- Language:
- English
- Description:
- Knowledge on the involvement of spinal COX-1 and COX-2 in pain due to osteoarthritis could be useful for better understanding of its pa thogenesis and therapy. In this study we have investigated a long-term pattern of expression and production of spinal COX-1 and COX-2 in the model of osteoarthritis induced in rats by injection of monoiodoacetate (MIA) into the knee joint. MIA injection produced thermal hyperalgesia (assessed by the plantar test) and tactile allodynia (measured with von Frey hairs). The pain measures reached maximum on the 5th day, then re mained relatively stable. The expression of spinal COX-2 mR NA reached maximum on day 5 (5.2 times; P<0.001) and remain ed increased until day 31 (4.9 times; P<0.001). Expression of spinal COX-1 mRNA increased gradually reaching maximum on the day 31 (4.5 times; P<0.001) when the relative expression of both genes was almost equal. The production of both proteins was almost similar at the beginning of the experiment. The highest production of COX-2 protein was observed on day 5 after the induction of osteoarthritis (increased 3.9 times). The levels of COX-1 protein increased gradually with maximum on day 31 (3.4 times). The present findings indicate that not only expression of COX-2 mRNA but also that of COX-1 mRNA is significantly increased in the spine during osteoarthritis pain. Thus, in contrast to inflammatory pain, the upregulation of spinal COX-1 may be important in osteoarthritis pain., M. Procházková, P. Zanvit, T. Doležal, L. Prokešová, M. Kršiak., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public