Number of results to display per page
Search Results
16612. Varieties of half lattice-ordered groups of monotonic permutations of chains
- Creator:
- Giraudet, Michèle and Rachůnek, Jiří
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- math, lattice-ordered groups, and monotonic permutations of chains
- Language:
- English
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
16613. Varieties of idempotent slim groupoids
- Creator:
- Ježek, Jaroslav
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- groupoid, variety, and nonfinitely based
- Language:
- English
- Description:
- Idempotent slim groupoids are groupoids satisfying $xx\=x$ and $x(yz)\=xz$. We prove that the variety of idempotent slim groupoids has uncountably many subvarieties. We find a four-element, inherently nonfinitely based idempotent slim groupoid; the variety generated by this groupoid has only finitely many subvarieties. We investigate free objects in some varieties of idempotent slim groupoids determined by permutational equations.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
16614. Various AKIP1 expression levels affect its subcellular localization but have no effect on NF-κB activation
- Creator:
- Keprová, A., Kořínková, L. , Křížová, I. , Hadravová, R., Kaufman, F., Pichová, I. , Ruml, T., and Rumlová, M.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- AKIP1, BCA3, protein aggregation, NF-kappa B, and transcription regulation
- Language:
- English
- Description:
- A-kinase interacting protein 1 (AKIP1) has been shown to interact with a broad range of proteins involved in various cellular processes, including apoptosis, tumorigenesis, and oxidative stress suggesting it might have multiple cellular functions. In this study, we used an epitope-tagged AKIP1 and by combination of immunochemical approaches, microscopic methods and reporter assays we studied its properties. Here, we show that various levels of AKIP1 overexpression in HEK-293 cells affected not only its subcellular localization but also resulted in aggregation. While highly expressed AKIP1 accumulated in electron-dense aggregates both in the nucleus and cytosol, low expression of AKIP1 resulted in its localization within the nucleus as a free, non-aggregated protein. Even though AKIP1 was shown to interact with p65 subunit of NF-κB and activate this transcription factor, we did not observe any effect on NF-κB activation regardless of various AKIP1 expression level.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
16615. Various aspects of sex and gender bias in biomedical research
- Creator:
- Plevkova, Jana, Brozmanova, Mariana, Harsanyiova, Jana, Sterusky, Miroslav, Honetschlager, Jan, and Buday, Tomas
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- sex bias, biomedical research, testosterone, and estrogen
- Language:
- English
- Description:
- The main role of research in medicine is to provide relevant knowledge which, after successful translation to clinical practice, improves the quality of healthcare. The sex bias which is still present in the majority of research disciplines prefers male subjects despite legislation changes in the US grant agencies and European research programme Horizon 2020. Male subjects (cells, animals) still dominate in preclinical research and it has detrimental consequences for women’s health and the quality of science. Opposite bias exists for data obtained mainly in animal models utilizing female subjects (e.g. research in multiple sclerosis, osteoporosis) with skewed outcomes for men affected by these diseases. Either way, scientists are producing results which compromise half of the population. Assumptions that females as cohorts are more variable and another assumption that the oestrous cycle should be tracked in case the females are enrolled in preclinical studies were proven wrong. Variability of male versus female cohorts are comparable and do not only stem from hormonal levels. The widespread prevalence of sex differences in human diseases ultimately requires detailed experiments performed on both sexes, unless the studies are specifically addressing reproduction or sex-related behaviors.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
16616. Vasa praevia: incidence, diagnostika, doporučené postupy
- Creator:
- Galčíková, Andrea
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, přehledy, and TEXT
- Subject:
- lidé, těhotenství, ženské pohlaví, vasa praevia--diagnóza--epidemiologie--ultrasonografie, ultrasonografie prenatální, ultrasonografie dopplerovská barevná--metody, komplikace těhotenství, rizikové faktory, kardiotokografie, směrnice pro lékařskou praxi jako téma, and císařský řez
- Language:
- Czech and English
- Description:
- Cíl práce: Podat přehled o diagnostických metodách a doporučených postupech pro vcestné cévy (vasa praevia) v těhotenství. Typ studie: Souhrnný článek. Metodika: Analýza dostupných literárních zdrojů. Závěr: Vasa praevia patří mezi závažné těhotenské komplikace s nízkou incidencí. Pokud nejsou vcestné cévy diagnostikovány prenatálně, představují vysoké riziko pro plod. Včasná prenatálně stanovená diagnóza významně snižuje perinatální morbiditu a mortalitu novorozence. Diagnostickou metodou volby je ultrasonografické vyšetření s použitím barevného dopplerovského zobrazení. V případě stanovení diagnózy vasa praevia prenatálně je doporučováno ukončení těhotenství elektivním císařským řezem dříve, než dojde k nástupu porodní činnosti nebo odtoku plodové vody., Objective: To report up–to date knowledge on diagnostic methods and recommended practices for vasa praevia in pregnancy. Study design: Review. Methods: Analysis of available literature resources. Conclusion: Vasa praevia is among the major pregnancy complications with a low incidence. If they are not diagnosed prenatally, pose a high risk to the fetus. Early prenatally established diagnosis significantly decrease perinatal morbidity and mortality of the newborn. The diagnostic method of choice is ultrasound scan using colour Doppler image. In the case of diagnosis of vasa praevia prenatally, it is recommended termination of the pregnancy by elective cesarean section before the onset of labor activity or rupture of membranes., and Andrea Galčíková
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
16617. Vascular stenosis asymmetry influences considerably pressure gradient and flow volume
- Creator:
- Novakova, L., Kolinsky, J., Adamec, J., Kudlicka, J., and Jan Malík
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, ateroskleróza, atherosclerosis, stenosis, dialysis access, pressure gradient, 14, and 612
- Language:
- English
- Description:
- Vascular stenosis is often described only by its percentage in both clinical and scientific praxis. Previous studies gave inconclusive results regarding the effect of stenosis eccentricity on its hemodynamic effect. The aim of this experimental study was to investigate and quantify the effect of stenosis severity and eccentricity on the pressure drop. A combination of pressure and flow measurements by Par ticle Imaging Velocimetry (PIV) method was used. Models of the same stenosis significance but with different levels of eccentricity were studied in vitro by PIV. This study has shown that stenosis asymmetry is associated with more profound pressure drop an d flow volume decrease. On the contrary, pressure drop and flow volume decrease were not further significantly influenced by the level of asymmetry. Hemodynamic changes associated with stenosis eccentricity must be taken into account in both clinical and s cientific studies., L. Novakova, J. Kolinsky, J. Adamec, J. Kudlicka, J. Malik., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
16618. Vaskulární demence
- Creator:
- Kovtun, Vladimír and Mészarosová, Jitka
- Type:
- model:article, article, Text, and TEXT
- Subject:
- vaskulární demence--epidemiologie--klasifikace--patofyziologie, neuropsychologické testy, neurologické manifestace, primární prevence, farmakoterapie, retrospektivní studie, and lidé
- Language:
- Czech and English
- Description:
- Vaskulární demence je druhou nejčastěji se vyskytující demencí (po demenci Alzheimerově). Autoři článku v souhrnném sdělení uvádějí základní epidemiologické údaje týkající se vaskulární demence. Předkládají přehled o klinickém obrazu tohoto onemocnění a shrnují současný pohled na jeho etiopatogenezi, dělení, diagnostiku a terapii., Vascular dementia is second commonest cause of dementia. The authors of the article have ióne a survey of essential epidemiological data concerning vascular dementia. They present a basic review of vascular dementia's picture and summarize the contemporary view of ethiopathogenesis, clinical discrimination. diagnostics and treatment of the disease., Vladimír Kovtun, Jitka Mészarosová, and Lit. 20
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
16619. Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimental heart failure
- Creator:
- Sporková, A., Zuzana Husková, Petra Škaroupková, Rami Reddy, N., Falck, J. R., Sadowski, J., and Luděk Červenka
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, hypertenze, hypertension, congestive heart failure, aorto-caval fistula, epoxyeicosatrienoic acids, 14, and 612
- Language:
- English
- Description:
- Pathophysiological mechanisms underlying the development of renal dysfunction and progression of congestive heart failure (CHF) remain poorly understood. Recent studies have revealed striking differences in the rol e of epoxyeicosatrienoic acids (EETs), active products of cytochrome P-450-dependent epoxygenase pathway of arachidonic acid, in the progression of aorto-caval fistula (ACF)-induced CHF between hypertensive Ren-2 renin transgenic rats (TGR) and transgene-negative normotensive Hannover Sprague-Dawley (HanSD) controls. Both ACF TGR and ACF HanSD strains exhibited marked intrarenal EETs deficiency and impairment of renal function, and in both strains chronic pharmacologic inhibition of s oluble epoxide hydrola se (sEH) (which normally degrades EETs) normalized EETs levels. However, the treatment improved the survival rate and attenuated renal function impairment in ACF TGR only. Here we aimed to establish if the reported improved renal function and attenuation o f progression of CHF in ACF TGR observed after sEH blockade depends on increased vasodilatory responsiveness of renal resistance arteries to EETs. Therefore, we examined the responses of interlobar arteries from kidneys of ACF TGR and ACF HanSD rats to EET-A, a new stable 14,15-EET analog. We found that the arteries from ACF HanSD kidneys rats exhibited greater vasodilator responses when compared to the ACF TGR arteries. Hence, reduced renal vasodilatory responsiveness cannot be responsible for the lack of beneficial effects of chronic sEH inhibition on the development of renal dysfunction and progression of CHF in ACF HanSD rats., A. Sporková, Z. Husková, P. Škaroupková, N. Rami Reddy, J. R. Falck, J. Sadowski, L. Červenka., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
16620. Vazospazmy jako komplikace subarachnoidálního krvácení – kazuistika
- Creator:
- Jurák, Lubomír, Buchvald, Pavel, Beneš, Vladimír, Kaiser, Miroslav, and Suchomel, Petr
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, kazuistiky, and TEXT
- Subject:
- vasospasmus intrakraniální--diagnóza--etiologie--patofyziologie--terapie, výsledek terapie, subarachnoidální krvácení--diagnóza--komplikace--patofyziologie--terapie, Glasgowská stupnice kómat, ruptura aorty--komplikace, ischemie mozku--diagnóza, magnetická rezonanční tomografie, angiografie--metody, neurochirurgické výkony, mozek--chirurgie, popis nemoci, blokátory kalciových kanálů--terapeutické užití, sloučeniny hořčíku--terapeutické užití, digitální subtrakční angiografie, angioplastika--metody--využití, hematom--chirurgie, statiny--terapeutické užití, mozek - krevní oběh--fyziologie, krevní průtok - rychlost--fyziologie, dospělí, ženské pohlaví, and lidé
- Language:
- Czech and English
- Description:
- Vazospazmy jsou považovány za hlavní příčinu vysoké mortality a špatné prognózy pacientů se subarachnoidálním krvácením způsobeným rupturou aneuryzmatu. Námi popisovaná kazuistika se týká 30leté pacientky, která byla přijata s Glasgow Coma Scale 14 a těžkou levostrannou hemiparézou. Počítačová tomografie odhalila subarachnoidální krvácení. Jeho příčinou byla ruptura aneuryzmatu na arteria cerebri media vpravo. Aneuryzma bylo zaklipováno. Pro symptomatické vazospazmy jsme opakovaně provedli mechanickou i farmakologickou angioplastiku. Přesto došlo k rozvoji ischemie v pravé mozkové hemisféře, což nás vedlo k dekompresivní kraniektomii. Finálně vazospazmy regredovaly a nastala úplná úprava neurologického deficitu. Čtyři roky po operaci je pacientka plně soběstačná, bez poruchy hybnosti končetin, s nedotčenými kognitivními funkcemi., Vasospasms are considered to be the major cause of high mortality and bad prognosis in patients with subarachnoid hemorrhage caused by a rupture of an aneurysm. Our case report describes a 30-year-old patient admitted with Glasgow Coma Scale 14 and severe left-sided hemiparesis. Computed tomography revealed subarachnoid hemorrhage. Its etiology was ruptured aneurysm of the right middle cerebral artery. The aneurysm was clipped. Mechanical and pharmacological angioplasty was repeatedly performed to manage symptomatic vasospasms. Despite these interventions, an ischemic lesion developed in the right brain hemisphere that prompted us to perform decompressive craniectomy. Finally, vasospasms, as well as the neurological deficit, disappeared. Four years after the surgery, the patient is independent, without any limb movement disorder and with normal cognitive functions., and L. Jurák, P. Buchvald, V. Beneš, III., M. Kaiser, P. Suchomel
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public