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25562. Variable expression of hypercholesterolemia in apolipoprotein E2* (Arg136 - Cys) Heterozygotes
- Creator:
- Jaroslav Hubáček, Jan Piťha, Petr Stávek, Schmitz, G., and Rudolf Poledne
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, sekvenování DNA, metabolismus lipidů, DNA sequencing, lipid metabolism, apolipoprotein E, rare mutation, PCR, 14, and 612
- Language:
- English
- Description:
- In the process of population screening for apo E gene polymorphism with the PCR and subsequent restriction analysis, we identified a female who demonstrated heterozygosity for an unusual restriction fragment caused by the loss of a CfoI restriction site. Sequence analysis of the apo E gene was performed and a carrier of the mutant allele with C - T substitution at cDNA position 3817 was identified, which caused an Arg136 - Cys change. The first-line relatives have been screened for this rare mutation with PCR and restriction analysis of PCR products. The complete lipoprotein parameters have been determined in the probands family. In the family, only one child had the same mutant allele as his mother had. The proband (7.49 mmol/l) with her siblings had hypercholesterolemia and a high body mass index (BMI 31.6 kg/m2). By contrast, her son had a normal lipid spectrum with normal BMI. We described the mutation apo E2* (Arg136 - Cys) in a family with elevated lipid levels, but there was no confirmation of the connection between this mutation and type III hyperlipoproteinemia or hyperlipoproteinemia at all. In the case of this mutation, other factors (mainly genetic) are important for the development of lipid metabolism disorders., J. A. Hubáček, J. Piťha, P. Stávek, G. Schmitz, R. Poledne., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
25563. Variable Lebesgue norm estimates for BMO functions
- Creator:
- Izuki, Mitsuo and Sawano, Yoshihiro
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- variable exponent, Morrey space, and BMO
- Language:
- English
- Description:
- In this paper, we are going to characterize the space ${\rm BMO}({\mathbb R}^n)$ through variable Lebesgue spaces and Morrey spaces. There have been many attempts to characterize the space ${\rm BMO}({\mathbb R}^n)$ by using various function spaces. For example, Ho obtained a characterization of ${\rm BMO}({\mathbb R}^n)$ with respect to rearrangement invariant spaces. However, variable Lebesgue spaces and Morrey spaces do not appear in the characterization. One of the reasons is that these spaces are not rearrangement invariant. We also obtain an analogue of the well-known John-Nirenberg inequality which can be seen as an extension to the variable Lebesgue spaces.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
25564. Variační počet, přirozený aparát fyziky
- Creator:
- Musilová, Jana and Musilová, Pavla
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- variační počet, variační metody, physics, calculus of variations, variational methods, matematická estetika, variační matematika, variační fyzika, 6, and 53
- Language:
- Czech and English
- Description:
- Říká se, že jedním ze znaků správné fyzikální teorie je její krása. Máme-li na mysli estetičnost matematickou, patří variační počet k matematickým metodám, které naplňují tento požadavek vrchovatě. Je také pravda, že správné (zkušeností a experimentem prověřené) fyzikální teorie bývají variační, tj. odvoditelné z variačního principu: Klasická mechanika, relativistická mechanika, kvantová mechanika, klasická elektrodynamika... Na zcela elementární úrovni předkládáme základní myšlenku a klasické postupy variačního počtu, s ukázkami použití v geometrii a fyzice. Zaměříme se pouze na variační princip prvního řádu, s důrazem na mechaniku, kde na rozdíl od teorie pole závisí řešené úlohy pouze na jedné nezávisle proměnné, ve fyzice obvykle na čase., It is said that one of the characteristic features of physical theories is their beauty. Having in mind the "mathematical aesthetic appearance" one can say that the calculus of variations highly fulfils this requirement! It is also well known that correct physical theories (those verified experimentally), are often variational, i.e. based on a variational principle: classical mechanics, relativistic mechanics, quantum mechanics, classical electrodynamics, etc. We present, at a very basic level, the fundamental ideas and classical approaches of the calculus of variations, including examples of their use in geometry and physics. We focus on the first order variational principle, emphasizing mechanics, because contrary to field theories, the variational problems in mechanics depend on one independent variable only (usually time in physics)., Jana Musilová, Pavla Musilová., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
25565. Variance bounds and excess volatility
- Creator:
- Allan Timmermann and CERGE-EI
- Publisher:
- CERGE-EI, Center of Excellence
- Format:
- print, svazek, and 26 stran.
- Type:
- model:monograph and TEXT
- Subject:
- Finance, akcie, stocks, ceny akcií, dividendy, kolísání cen, kolísání dividend, 336.763.2, (048.8), 4, and 336.7
- Language:
- English and Czech
- Description:
- Alan Timmermann. and České resumé
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
25566. Variance-constrained H∞ finite-horizon filtering for multi-rate time-varying networked systems based on stochastic protocols
- Creator:
- Lyu, Ming , Zhang, Jie , and Bo, YuMing
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- H∞ finite-horizon filtering, muti-rate communication, stochastic protocol (SP), and time-varying systems
- Language:
- English
- Description:
- In this paper, the variance-constrained H∞ finite-horizon filtering problem is investigated for a class of time-varying nonlinear system under muti-rate communication network and stochastic protocol (SP). The stochastic protocol is employed to determine which sensor obtains access to the muti-rate communication network in order to relieve communication burden. A novel mapping technology is applied to characterize the randomly switching behavior of the data transmission resulting from the utilization of the SP in muti-rate communication network. By using relaxation method, sufficient conditions are derived for the existence of the finite-horizon filter satisfying both the prescribed H∞ performance and the covariance requirement of filtering errors, and the solutions of filters satisfying the above indexes are obtained by using linear matrix inequalities. Finally, the validity and effectiveness of the proposed filter scheme are verified by numerical simulation.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
25567. Variant abductor pollicis longus muscle
- Creator:
- Paul, Shipra
- Type:
- model:article and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
25568. Variants of learning algorithm based on Kolmogorov theorem
- Creator:
- Neruda, Roman, Arnošt, Štědrý, and Drkošová, Jitka
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- Kolmogorov networks, approximation theory, and parallel algorithms
- Language:
- English
- Description:
- A thorough analysis of theoretical and computational properties of Kolmogorov learning algorithm for feedforward neural networks lead us to proposal of efficient sequential and parallel impleinentation. A novel approach to parallelization is presented which combines our previous rcsnlts in order to achieve higher parallel speed-up.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
25569. Variation in CDKAL1 gene is associated with therapeutic response to sulphonylureas
- Creator:
- Zbynek Schroner, Martin Javorský, Halušková, J., Klimčáková, L., Babjaková, E., Fabianová, M., Slabá, E., Kozárová, M., and Ivan Tkáč
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, pharmacogenetics, sulphonylureas, CDKAL1, glycemic control, type 2 diabetes, 14, and 612
- Language:
- English
- Description:
- The aim of the present pilot pharmacogenetic study was to analyse quantitative effects of sulphonylurea treatment in addition to metformin on parameters of glycemic control with respect to CDKAL1 genotypes in patients with type 2 diabetes. Effect of 6-month sulphonylurea therapy on glycemic control according to CDKAL1 genotypes was evaluated in 101 patients with type 2 diabetes who failed to achieve glycemic control on metformin monotherapy. CDKAL1 rs7756992 polymorphism was determined by melting curve analysis of small amplicon following real-time PCR. After sulphonylurea treatment fasting plasma glucose (FPG) levels were significantly different (p=0.045) among three CDKAL1 genotype groups (AA: n=49; AG: n=36; GG: n=16). In a dominant genetic model, carriers of the G-allele (AG+GG, n=52) achieved significantly lower FPG levels in comparison with patients with the AA genotype (6.90±1.08 vs. 7.48±1.12 mmol/l, p=0.013). Consequently, adjusted ΔFPG was significantly higher in the AG+GG compared to the AA group (1.48±1.51 vs. 1.02±1.33 mmol/l, p=0.022). Similar trend was observed for HbA1c levels, but the difference between the genotype groups did not reach the level of statistical significance. Relatively small number of included patients is a limitation of the present study. In conclusion, our results suggest that the magnitude of FPG reduction after 6-month sulphonylurea treatment in patients with type 2 diabetes is related to the variation in CDKAL1., Z. Schroner ... [et al.]., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
25570. Variation in dung beetle (Coleoptera: Scarabaeoidea) assemblages with altitude in the Bulgarian Rhodopes Mountains: A comparison
- Creator:
- Lobo, Jorge M., Chehlarov, Evgeni, and Guéorguiev, Borislav
- Type:
- article, model:article, and TEXT
- Subject:
- Dung beetles, Scarabaeoidea, altitudinal variation, Rhodopes Mountains, European mountain assemblages, and species richness
- Language:
- English
- Description:
- Variation with altitude in the composition of dung beetle assemblages and species richness was measured by sampling in spring, summer and autumn, both manually and with pitfall traps at twelve localities in the western Rhodopes Mountains. Non-parametric estimates indicate that most of the regional species pool was collected, some 73% of all taxa previously recorded in the entire region. The rate of species richness decrease with altitude is around 11 species per km, with an evident altitudinal change in the incidence of two main dung beetle functional groups in which Aphodiinae species begin to dominate Rhodopes assemblages at around 1400-1500 m. Species richness of dung pats is dominated by Scarabaeinae in spite of the fact that the number of Aphodiinae species is highest at each locality. Thus, Aphodiinae species are the main contributors to both local and regional pool richness and to species turnover between localities. These characteristics are similar to those observed in the assemblages from another European mountain range, also located near the Mediterranean-Eurosiberian boundary, the Iberian Central System. These results suggest that eastern European dung beetle assemblages are similar in compositional turnover and species richness variation with altitude to that observed in western Europe and North America.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public