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45492. Žilní přístupy pro střednědobou a dlouhodobou protinádorovou léčbu
- Creator:
- Maňásek, Viktor
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, kazuistiky, and TEXT
- Subject:
- parenterální infuze, zaváděcí katétry, katetrizace centrálních vén--metody, ošetřovatelství - vzorové postupy, nádory--terapie, periferní katetrizace, centrální žilní katétry, dospělí, staří, ženské pohlaví, lidé, mužské pohlaví, nádory prsu--terapie, nádory slinivky břišní--terapie, and myelodysplastické syndromy--terapie
- Language:
- Czech and English
- Description:
- Protinádorová farmakoterapie je vedena dominantně parenterální formou, a proto je volba adekvátního žilního vstupu v onkologii zásadním tématem, nabývajícím na významu s rozšiřováním možností druhů žilních katétrů, které jsou k dispozici. Periferní žilní systém je navíc v některých případech při dlouhodobé léčbě výrazně zatěžován, neboť celá řada látek má nevyhovující vlastnosti pro periferní aplikaci – hlavně pH, osmolalitu a chemickou strukturu. Permanentní centrální venózní vstup nabízí šetření periferního žilního systému, je prevencí paravazace a lze jej využívat ve většině případů k odběrům krve. Kromě portů a tunelizovaných centrálních kanyl zažívá renesanci inzerce periferně implantovaných centrálních katétrů (PICC), které splňují kritéria permanentního centrálního vstupu. Uvádíme indikační kritéria pro implantaci jednotlivých druhů vstupů s přihlédnutím k vlastnostem pacienta, charakteru a délce podávané léčby. V rámci Společnosti pro porty a permanentní katétry jsme definovali několik oblastí onkologické péče, kdy můžeme preferovat inzerci PICC před ostatními druhy žilních katetrů., The choice of adequate venous access device is a key issue in oncology since anticancer drug therapy is administered via the parenteral route predominantly. An increasing importance of this topic has been observed with the expansion of various types of venous catheters available. In some cases, long-term therapy places a heavy burden on the peripheral venous system because many substances have unsatisfactory properties for peripheral administration – mainly the pH, osmolality and chemical structure. A long-term central venous access device offers a way to spare the peripheral venous system, prevents extravasation, and can be used for blood sampling in most cases. In addition to ports and tunneled venous access devices, there is a renaissance in insertion of peripherally inserted central catheters (PICCs) that meet the criteria for a permanent central venous access device. The indication criteria for the insertion of various kinds of devices are presented, taking into account the patient characteristics as well as the type and duration of the treatment administered. As part of the Society for Ports and Permanent Catheters activities, several areas of oncology care have been defined where the insertion of PICCs is preferred to other types of venous catheters., Viktor Maňásek, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
45493. Žilní trombóza jako komplikace ventrikuloatriálního shuntu – kazuistika
- Creator:
- Jurák, Lubomír, Buchvald, Pavel, Beneš, Vladimír, Oršulík, D., and Suchomel, Petr
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, kazuistiky, and TEXT
- Subject:
- lidé, mladý dospělý, ženské pohlaví, hydrocefalus--chirurgie, ventrikuloperitoneální zkrat, shunty pro odvod mozkomíšního moku--škodlivé účinky, tromboembolie--komplikace, žilní trombóza--diagnóza--farmakoterapie--komplikace, enoxaparin--aplikace a dávkování, warfarin--aplikace a dávkování, mozek--radiografie, tomografie rentgenová počítačová, srdeční síně, venae jugulares--patologie--ultrasonografie, vena brachiocephalica--patologie--ultrasonografie, progrese nemoci, výsledek terapie, and ventrikuloatriální shunt
- Language:
- Czech and English
- Description:
- Trombembolická nemoc je jedna z možných komplikací ventrikuloatriálního shuntu. Námi popisovaná kazuistika se týká 20leté pacientky s prenatálně diagnostikovaným obstrukčním hydrocefalem, pro který jí byl postnatálně zaveden nejprve ventrikuloperitoneální a později pro poruchu resorpce moku v peritoneální dutině ventrikuloatriální shunt. Dva roky po jeho zavedení byla pacientka přijata pro opakované stavy dušnosti, ranní otoky obličeje a krku a dva dny trvající vertigo s pocitem tlaku v hlavě. Na ultrasonografii žil byl nalezen trombus v oblasti levé vnitřní jugulární žíly a okolo atriálního konce zavedeného zkratového systému. Byla započata antikoagulační terapie v podobě subkutánně aplikovaného nízkomolekulárního heparinu enoxaparinu. Ventrikuloatriální shunt byl později extrahován a nahrazen opět shuntem ventrikuloperitoneálním. Finálně došlo k rekanalizaci tří ze čtyř uzavřených žil. Po jednom roce léčby trombózy je pacientka bez zásadních subjektivních i objektivních potíží a medikuje warfarin., Thromboembolic disease is one of possible complications of ventriculoatrial shunt. Our case report describes a 20-year-old patient who was prenatally diagnosed with obstructive hydrocephalus and was postnatally treated with a ventriculoperitoneal shunt and, subsequently, because of cerebrospinal fluid malabsorption in the peritoneal cavity, with ventriculoatrial shunt. Two years after the surgery, the patient was admitted with recurrent symptoms of dyspnoea, morning oedema of the face and neck and two-day history of vertigo with feeling of pressure inside her head. Venous ultrasonography revealed thrombus in the left internal jugular vein and around the atrial end of the shunt. Anticoagulation therapy using subcutaneous application of low-molecular-weight heparin enoxaparin was started. Ventriculoatrial shunt was removed and replaced with ventriculoperitoneal shunt. Eventually, three of four closed veins were recanalized. After one year of thrombosis treatment, the patient is without any significant subjective or objective problems and she is treated with warfarin. Key words: thromboembolic disease – venous thrombosis – ventriculoatrial shunt – hydrocephalus – anticoagulation therapy The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers., and L. Jurák, P. Buchvald, V. Beneš III, D. Oršulík, P. Suchomel
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
45494. Zimní urologické sympozium ve Špindlerově Mlýně
- Creator:
- Havlová, Klára, Čechová, Marcela, and Dušková, Kateřina
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, and TEXT
- Subject:
- kongresy jako téma and urologie
- Language:
- Czech and English
- Description:
- Klára Havlová, Marcela Čechová, Kateřina Dušková
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
45495. Zinc alters cytoskeletal integrity and migration in colon cancer cells
- Creator:
- Rudolf, Emil
- Type:
- model:article and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
45496. Zinc and copper in the tissues and serum of cadmium intoxicated Guinea-pigs: influence of vitamin C
- Creator:
- Kadrabová, J., Maďarič, A., and Ginter, E.
- Type:
- article, model:article, and TEXT
- Subject:
- cadmium, zinc, copper, copper deficiency, vitamin C, and Guinea-pigs
- Language:
- English
- Description:
- Cadmium in the dose of 1 mg/animal/day was administered to guinea-pigs in the form of CdCl2 dissolved in drinking water during short-term (5 weeks) and subchronic (12 weeks) experiments. Both the control and cadmium-treated groups were divided into two subgroups, according to low (2 mg/animal/day) and high (100 mg/animal/day) vitamin C intake. Subchronic cadmium treatment caused copper deficiency indicated by a dramatic decrease of copper concentration in the liver and serum and by its moderate decrease in the testes and brain. Cadmium significantly increased zinc concentrations in the kidneys during the whole experiment and decreased the level of zinc in the serum after subchronic cadmium treatment. In the control groups, the levels of zinc and copper in the serum were lowered after 5 weeks of high vitamin C doses. High doses of vitamin C in cadmium-treated guinea-pigs decreased the levels of copper in the testes, brain and serum. These observations suggest that cadmium intake in relatively high doses might potentiate the development of copper deficiency, and high doses of vitamin C aggravate, to a certain extent, copper depletion in some important organs and serum of guinea-pigs.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
45497. Zindagīnāmā: The undivided Panjab of Krishna Sobti
- Creator:
- Offredi, Mariola
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- Zindagīnāmā and Krishna Sobti
- Language:
- English
- Description:
- At the heart of Krishna Sobti’s novel Zindagīnāmā (A book of life, 1979) is a village of the Gujrat district (western Panjab, now Pakistan), in the Chaj Doab. The setting is contained within three bands: the outermost band is the village, where most people are Muslim but which is dominated by Śāhjī’s Hindu Khatri family, and above all by Śāhjī himself, a landowner and moneylender. Inside this band is the havelī (large walled house) owned by Śāhjī, and inside the havelī band is the large room ( baiṭ hak) where the men gather. Inside the havelī band there are also the rooms belonging to the women’s realm. Additionally there are several external settings. The village is connected to the world at large through news of events, recounted or witnessed by characters who come into contact with Śāhjī. The period covered is 1900-1916. The narrative consists chiefly of dialogue between the various characters. The language is a mixed vocabulary of Hindi, Urdu and Panjabi. The novel is highly complex, rich in incident and in its cast of characters: Hindu, Sikh and Muslim. The first distinction to be drawn is between the women’s and the men’s world. The women’s world is one of emotions. The men’s world is political in the broad sense of the word and includes Śāhjī business dealings with Muslim Jat tenants. The gatherings in the baiṭ hak of Śāhjī are well attended, and many of the guests are Muslims. Interests sometimes converge and more often diverge, but Śāhjī always handles the conversation skillfully, diplomatically changing the subject when delicate issues such as the economy, politics and, indirectly, religion are raised. Śāhjī’s work as a mediator should not be seen purely as a way of protecting his personal interests. In reality, by mediating in different areas – economic, political and religious – he keeps the village united, providing cultural cohesion. Nonetheless, in Zindagīnāmā, the economic factor emerges repeatedly as the cause of the future Partition.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
45498. Zionism in the Bohemian Lands Before 1918 /
- Creator:
- Wein, Martin Joachim,
- Type:
- text
- Subject:
- sionismus, Židé, židovské osídlení, and české země 1848-1918
- Language:
- English
- Rights:
- unknown
45499. Zionists in interwar Czechoslovakia :
- Creator:
- Lichtenstein, Tatjana
- Type:
- text and monografie
- Subject:
- Vnitropolitický vývoj, politický život, sionismus, Židé, nacionalismus, Československo 1918-1938, and dějiny židů
- Language:
- English
- Rights:
- unknown
45500. Živodní osudy a botanická činnost Slavomila Hejného
- Creator:
- Krahulec, František
- Type:
- article and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/