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232. Lehrbuch der Chirurgie und Operationslehre: Vorlesungen für praktische Ärtze und Studirende
- Creator:
- Eduard Albert
- Publisher:
- Urban & Schwarzenberg
- Format:
- print, text, regular print, and iv, 604 s. : il. ; 24 cm
- Type:
- model:monograph and TEXT
- Subject:
- Ortopedie. Chirurgie. Oftalmologie, Učební osnovy. Vyučovací předměty. Učebnice, chirurgie, břišní chirurgie, nemoci konečníku, mužské pohlavní ústrojí, 617-089, 617.55-089, 616.351, 616.64/.69, (075.8), 14, 22, 617, and 37.016
- Language:
- German
- Description:
- 3. Bd, Die chirurgischen Krankheiten des Bauches, des Mastdarms und der Scrotalhöhle, von Eduard Albert, and Obsahuje bibliografické odkazy
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
233. Lehrbuch der Somatologie und Hygiene für Lehrer- und Lehrerinnenbildungsanstalten
- Creator:
- Hanausek, Thomas Franz
- Publisher:
- F. Tempsky
- Format:
- svazek, bez média, print, text, regular print, and v, 158 stran : ilustrace
- Type:
- model:monograph and TEXT
- Subject:
- 613, 14, anatomie člověka, zdraví, hygiena, výživa člověka, and Hygiena. Lidské zdraví
- Language:
- German
- Description:
- bearb. von T. F. Hanausek and Converted from MODS to DC version 1.8 (EE patch 2018/05/24)
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
234. Levels of adipokines and some steroids during the menstrual cycle
- Creator:
- Šrámková, M., Michaela Dušková, Vítků, J., Josef Včelák, Petr Matucha, Olga Bradnová, Cordeiro, J. de, and Luboslav Stárka
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, menstruační cyklus, steroidní hormony, menstrual cycle, steroid hormons, adipokines, SHBG, food intake related hormones, 14, and 612
- Language:
- English
- Description:
- The cyclical effects of hormones during the menstrual cycle (MC) are not just responsible for driving ovulation, but also have significant influence on dietary intake and appetite, as well as psychological and behavioral changes. The aim of our study was to describe changes and relationships between the MC and selected steroids, adipokines and food intake-related hormones. Twenty-seven women with regular menstrual cycles were included in the study, and their hormonal spectrum was measured in regular intervals starting from the first day of their cycle. Classical changes in gonadotropins, estrogens and progesterone during the menstrual cycle are accompanied by less striking but significant changes in 17-hydroxyprogesterone and testosterone. No significant changes show dehydroepiandrosterone and its 7-oxygenated metabolites. Adipokines show a tendency to increase during ovulation, while ghrelin and resistin decrease. There is also a remarkable association of sex hormone-binding globulin on the day of the cycle. Our results demonstrate that changes to adipokines during the menstrual cycle are not substantial, but nonetheless can play a role in the changes of food intake described in the literature. Precise descriptions of physiological changes in healthy women are important in helping us understand the significance of the changes accompanying various pathological states., M. Šrámková, M. Dušková, J. Vítků, J. Včelák, P. Matucha, O. Bradnová, J. de Cordeiro, L. Stárka., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
235. Links between the circadian rhythm, obesity and the microbiome
- Creator:
- Rácz, B, Markéta Dušková, Luboslav Stárka, Vojtěch Hainer, and Marie Kunešová
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- leptin, inzulín, insulin, sleep disruption, night workers, night eating syndrome, ghrelin, 14, and 612
- Language:
- English
- Description:
- Obesity is linked to a wide range of serious illnesses. In addition to the important impact on the health of the individual, obesity also has a substantial impact on the economy. Disruption of physiological day-night cycles could contribute to the increased incidence of obesity. According to the American National Sleep Federation, the percentage of the people who reported a sleep duration of six hours or less increased from 12 to 37 % over ten years. Insufficient sleep leads not only to an increase of the total calorie intake but changes the meal preference in favor of palatable foods and meals with high carbohydrate content. A decrease of leptin and increase of ghrelin levels caused by sleep deficiency can also play a role. In addition to the higher caloric intake, the timing of food consumption should be taken into account. The same meal eaten during the night versus the day is associated with increased postprandial glucose and triglyceride levels. The gut microbiome has also been recently understood as an endocrine system, with links between the gut microbiome and circadian rhythm changes possibly influencing increased obesity., B. Rácz, M. Dušková, L. Stárka, V. Hainer, M. Kunešová., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
236. Lipasin / betatrophin is differentially expressed in liver and white adipose tissue without association with insulin resistance in Wistar and Goto-Kakizaki rats
- Creator:
- Monika Cahová, David Habart, Olejár, T., Zuzana Berková, Zuzana Papáčková, Daňková, H., Alena Lodererová, Marie Heczková, and František Saudek
- Format:
- print, bez média, and svazek
- Type:
- article, články, journal articles, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, inzulinová rezistence, játra, tuková tkáň, insulin resistance, liver, adipose tissue, Lipasin / betatrophin, Goto-Kakizaki, 14, and 612
- Language:
- English
- Description:
- Lipasin is a recently identified lipokine expressed predominantly in liver and in adipose tissue. It was linked to insulin resistance in mice and to type 1 and type 2 diabetes (T1D, T2D) in humans. No metabolic studies concerning lipasin were performed yet in rats. Therefore, we used rat model of T2D and insulin resistance, Goto-Kakizaki (GK) rats, to determine changes of lipasin expression in liver and in white adipose tissue (WAT) over 52 weeks in the relation to glucose tolerance, peripheral tissue insulin sensitivity and adiposity. GK rats were grossly glucose intolerant since the age of 6 weeks and developed peripheral insulin resistance at the age of 20 weeks. Expression of lipasin in the liver did not differ between GK and Wistar rats, declining with age, and it was not related to hepatic triacylglycerol content. In WAT, the lipasin expression was significantly higher in Wistar rats where it correlated positively with adiposity. No such correlation was found in GK rats. In conclusion, lipasin expression was associated neither with a mild age-related insulin resistance (Wistar), nor with severe genetically-based insulin resistance (GK)., M. Cahová, D. Habart, T. Olejár, Z. Berková, Z. Papáčková, H. Daňková, A. Lodererova, M. Heczková, F. Saudek., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
237. Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease
- Creator:
- Zakaria, R., Wan Yaacob, W. M. H., Othman, Z., Long, I., Ahmad, A. H., and Al-Rahbi, B.
- Format:
- print, bez média, and svazek
- Type:
- article, články, journal articles, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, Alzheimerova choroba, Alzheimer's disease, lipopolysaccharide, memory impairment, rats, 14, and 612
- Language:
- English
- Description:
- Alzheimer’s disease (AD) is a primary cause of dementia in the middle-aged and elderly worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to test potential therapeutic agents for disease modification. Among the non-genetically manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal model is commonly used. This review paper aims to discuss the possible factors that influence rats’ response following LPS injection. Factors such as dose of LPS, route of administration, nature and duration of exposure as well as age and gender of animal used should be taken into account when designing a study using LPS-induced memory impairment as model for AD., R. Zakaria, W. M. H. Wan Yaacob, Z. Othman, I. Long, A. H. Ahmad, B. Al-Rahbi., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
238. Lipopolysaccharide-induced necroptosis of brain microvascular endothelial cells can be prevented by inhibition of endothelin receptors
- Creator:
- Abdul, Y., Ward, R., Ergul, A., and Dong, G.
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- fyziologie člověka, human physiology, LPS, Necroptosis, Apoptosis, Ferroptosis, Endothelin, 14, and 612
- Language:
- English
- Description:
- Over activation of the endothelin-1 (ET-1) system in disease states contributes to endothelial dysfunction. On the other hand, ET-1 promotes proliferation and survival of endothelial cells. Regulation of programmed cell death (PCD) pathways is critical for cell survival. Recently discovered necroptosis (regulated necrosis) is a pathological PCD mechanism mediated by the activation of toll like receptor 4 (TLR4), which also happens to stimulate ET-1 production in dendritic cells. To establish the effect of ET-1 on PCD and survival of human brain microvascular endothelial cells (BMVECs) under control and inflammatory conditions, BMVECs were treated with ET-1 (10 nM, 100 nM and 1 μM) or lipopolysaccharide (LPS, 100 ng/ml). ET receptors were blocked with bosentan (10 μM). Under normal growth conditions, exogenous ET-1 reduced BMVEC viability and migration at a relatively high concentration (1 μM). This was accompanied with activation of necroptosis and apoptosis marker genes. LPS decreased endogenous ET-1 secretion, increased ETB receptor expression and activated necroptosis. Even though ET-1 levels were low (less than 10 nM levels used under normal growth conditions), blocking of ET receptors with bosentan inhibited the necroptosis pathway and improved the cell migration ability of BMVECs, suggesting that under inflammatory conditions, ET-1 activates PCD pathways in BMVECs even at physiological levels., Y. Abdul, R. Ward, G. Dong, A. Ergul., and Seznam literatury
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
239. Lord kancléř Francis Bacon z Verulamu a jeho essaye
- Creator:
- Francis Bacon and Břetislav Foustka
- Publisher:
- Česká akademie věd a umění
- Format:
- print and 176 s.
- Type:
- text, volume, eseje, prameny, model:monograph, and TEXT
- Subject:
- Filozofické systémy a hlediska, Bacon, Francis, 1561-1626, anglická filozofie, etika, politika, 14(410.1), 32, 17, (0:82-4), (093), 5, and 14
- Language:
- Czech and Undetermined
- Description:
- napsal a přeložil Břetislav Foustka.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
240. Lower physical fitness in patients with primary aldosteronism is linked to the severity of hypertension and kalemia
- Creator:
- Vladimír Tuka, Martin Matoulek, Tomáš Zelinka, Rosa, J., Ondřej Petrák, Mikeš, O., Zuzana Krátká, Branislav Štrauch, Robert Holaj, and Jiří Widimský
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, tělesná kondice, physical fitness, primary hyperaldosteronism, exercise blood pressure, exercise stress test, 14, and 612
- Language:
- English
- Description:
- Hypokalemia as a typical feature of primary aldosteronism (PA) is associated with muscle weakness and could contribute to lower cardio pulmonary fitness. The aim of this study was to describe cardiopulmonary fitness and exercise blood pressure and their determinants during a symptom-limited exercise stress test in patients with PA. We performed a cross-sectional study of patients with confirmed PA who were included before adrenal vein sampling on whom a symptom-limited exercise stress test with expired gas analysis was performed. Patients were switched to the treatment with doxazosin and verapamil at least tw o weeks befor e the study. In 27 patients (17 male) the VO 2peak was 25.4± 6.0 ml/k g/min which corresponds to 80.8 ±18.9 % of Czech national norm. Linear regression analysis shows that VO 2peak de pends on doxazosin dose (DX) (p=0.001) and kal emia (p= 0.02): VO 2peak = 4.2 - 1.0 * DX + 7.6 * Ka lemia. Patients with higher doxazosin doses had a longer history of hypertension and had used more antihypertensives before examination, thus indicating that VO 2peak also depends on the severity of hypertension. In patients with PA, lower cardiopulmonary fitness depends inversely on the severity of hypertension and o n lower plasma potassium level., V. Tuka, M. Matoulek, T. Zelinka, J. Rosa, O. Petrák, O. Mikeš, Z. Krátká, B. Štrauch, R. Holaj, J. Widimský Jr., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public