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502. Does impedance measure a functional state of the body fat?
- Creator:
- Renata Větrovská, Zdeněk Vilikus, Klaschka, J., Zuzana Stránská, Štěpán Svačina, Šárka Svobodová, and Martin Matoulek
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, tělesné složení, obezita, body composition, obesity, DEXA, fat mass, anthropometric methods, fat tissue functional properties, 14, and 612
- Language:
- English
- Description:
- The aim was to compare methods of body fat measurement in different BMI groups. An additional aim was to discuss differences reflecting the structural and functional changes of fat tissue. The study group included 130 adult Caucasian women stratified by body mass index (BMI): 18-24.99 (n=30), 25-29.99 (n=26), 30-34.99 (n=33), 35-39.99 (n=30), and BMI ≥ 40 (n=11). Bioelectrical impedance was performed using Tanita TBF 410 GS, Bodystat 1500, and Omron BF 300. A caliper type Best was also applied. Correspondence of four methods with DEXA was assessed using the Bland-Altman and ANOVA analyses. Measurements by BIA were not si gnificantly different from DEXA up to BMI of 30, but DEXA significantly overestimated in the higher BMI subgroup by all three methods. Caliper measurement significantly underestimated DEXA in all BMI subgroups. BIA methods overestimated DEXA for the obese subjects. Tanita did statistically the best. The Caliper test appeared less preferable than the BIA methods, especially in the higher BMI subgroup. DEXA and Caliper measurements seem to be the best estimate of structural (anatomical) fat quantity. We hypothesize that BIA methods could also measure some other physiopathological conditions like inflammation, hydration or cell infiltration of fat., R: Větrovská, Z. Vilikus, J. Klaschka, Z. Stránská, Š. Svačina, Š. Svobodová, M. Matoulek., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
503. Does inhibition of aldose reductase contribute to the anti-inflammatory action of setipiprant ?
- Creator:
- Ballekova, J., Soltesova-Prnova, M., Magdaléna Májeková, and Stefek, M.
- Format:
- print, bez média, and svazek
- Type:
- article, články, journal articles, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, astma, záněty, asthma, inflammations, setipiprant, aldose reductase inhibition, androgenic alopecia, 14, and 612
- Language:
- English
- Description:
- The aim of this study was to investigate aldose reductase inhibitory action of setipiprant as a potential additional mechanism contributing to its anti-inflammatory action. Aldose reductase activity was determined by spectrophotometric measuring of NADPH consumption. Setipiprant was found to inhibit aldose reductase/NADPH-mediated reduction of 4-hydroxynonenal, 4-hydroxynonenal glutathione and prostaglandin H2 substrates, all relevant to the process of inflammation. Molecular modeling simulations into the aldose reductase inhibitor binding site revealed an interaction pattern of setipiprant. Considering multifactorial etiology of inflammatory pathologies, it is suggested that, in addition to the antagonizing prostaglandin D2 receptor, inhibition of aldose reductase may contribute to the reported anti-inflammatory action of setipiprant., J. Ballekova, M. Soltesova-Prnova, M. Majekova, M. Stefek., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
504. Does long-term experimental antiorthostasis lead to cardiovascular deconditioning in the rat?
- Creator:
- Raffai, Gábor, Csekő,C., Kocsis, L., Dézsi, L., and Monos, E.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, antiorthostasis, baroreflex sensitivity, cardiovascular deconditioning, microgravity, 14, and 612
- Language:
- English
- Description:
- Microgravity or simulated microgravity induces acute and chronic cardiovascular responses, whose mechanism is pivotal for understanding of physiological adaptation and pathophysiological consequences. We investigated hemodynamic responses of conscious Wistar rats to 45º head-down tilt (HDT) for 7 days. Arterial blood pressure (BP) was recorded by telemetry. Heart rate (HR), spectral properties and the spontaneous baroreflex sensitivity (sBRS) were calculated. Head-up tilt (HUT) was applied for 2 h before and after HDT to assess the degree of any possible cardiovascular deconditio ning. Horizontal control BP and HR were 112.5±2.8 mmHg and 344.7±10 bpm, respectively. HDT elicited an elevation in BP and HR by 8.3 % and 8.8 %, respectively, in less than 1 h. These elevations in BP and HR were maintained for 2 and 3 days, respectively, and then normalized. Heart rate variability was unchanged, while sBRS was permanently reduced from the beginning of HDT (1.01±0.08 vs. 0.74±0.05 ms/mmHg). HUT tests before and after HDT resulted in BP elevations (6.9 vs. 11.6 %) and sBRS reduction (0.44 vs. 0.37 ms/mmHg), respectively. The pressor response during the post-HDT HUT test was accompanied by tachycardia (13.7 %). In conclusion, chronic HDT does not lead to symptoms of cardiovascular deconditioning. However the depressed sBRS and tachycardic response seen during the post-HDT HUT test may indicate disturbances in cardiovascular control., G. Raffai ... [et al.]., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
505. Does Magnesium Dysbalance Participate in the Development of Insulin Resistance in Early Stages of Renal Disease?
- Creator:
- Katarína Šebeková, Štefíková, K., Daniela Polakovičová, Viera Spustová, and Rastislav Dzúrik
- Format:
- print, bez média, and svazek
- Type:
- article, studie, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, 31P NMR spectroscopy, Erythrocyte, Magnesium, Insulin resistance, Obesity, Kidney Disease, 14, and 612
- Language:
- English
- Description:
- We investigated the potential role of magnesium (Mg) dysbalance in the pathogenesis of insulin resistance (IR) in patients with mildly-to-moderately decreased renal function (creatinine: 142.8±11.0 mmol/l). The data were compared to those of 8 age- and sex-matched healthy controls (CTRL). The standard oral glucose tolerance test (oGTT) was performed in 61 patients. Twenty-two patients were classified as IR according to their values on fasting and after-load immunoreactive insulin concentrations. Serum and total erythrocyte Mg (tErMg) (atomic absorption spectro-photometry) and free erythrocyte Mg (fErMg) concentrations (31P NMR spectroscopy) were determined prior to and two hours after the glucose load. Ten out of 39 insulin-sensitive (IS) patients, but only one out of 22 insulin-resistant (IR) patients, had a low basal fErMg concentration (<162.2 mmol/l, c2, p<0.01). IR patients had higher serum Mg, total erythrocyte Mg and bound erythrocyte Mg (bErMg) concentrations (both before and after glucose load) when compared with the IS group. Both groups responded to the glucose load with a significant decrease in serum Mg concentration (within the normal range), while the IR group also exhibited a decline in tErMg and bErMg. The mean sum of insulin needed to metabolize the same glucose load correlated positively with tErMg (r=0.545, p<0.01) and bErMg (r=0.560, p<0.01) in the IR patients. It is concluded that, at an early stage of renal dysfunction, IR is not associated with the decline in free erythrocyte Mg concentration, but the magnesium handling in red blood cells is altered., K. Šebeková, K. Štefíková, D. Polakovičová, V. Spustová, R. Dzúrik., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
506. Does obstructive sleep apnea worsen during REM sleep?
- Creator:
- Peregrim, I., Grešová, S., Mária Pallayová, Fulton, B. L., Štimmelová, J., Bačová, I., Mikul'aková, A., Zoltán Tomori, and Viliam Donič
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, apnoe, apnea, obstructive sleep apnea, apnoe-hypopnoe-index, body position, mixed apnea, 14, and 612
- Language:
- English
- Description:
- I. Peregrim ... [et. al.]. and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
507. Does the treatment of primary hyperaldosteronism influence glucose tolerance?
- Creator:
- Branislav Štrauch, Jiří Widimský, Gustav Šindelka, and Jan Škrha
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, krevní tlak, blood pressure, primary hyperaldosteronism, impaired glucose tolerance, 14, and 612
- Language:
- English
- Description:
- Primary hyperaldosteronism (PH) is frequently considered to be a secondary form of diabetes mellitus (DM). In our previous study we attempted to evaluate the prevalence of DM among patients with PH compared to control subjects with essential hypertension (EH). We have noted a relatively high prevalence of DM and impaired glucose tolerance in PH, but the differences between the PH and EH groups did not reach statistical significance. We performed this study to assess whether the effective treatment of PH (surgical and conservative) would improve the glucose tolerance. We have studied 24 patients with PH of the following two subtypes: aldosterone-producing adenoma (APA) treated with adrenalectomy and idiopathic hyperaldosteronism (IHA) treated with spironolactone. No significant changes of glucose levels were found in the 60th and 120th min of the oral glucose tolerance test (OGTT) in the APA group. On the other hand, fasting glucose levels were decreased significantly after adrenalectomy. Plasma glucose levels were significantly increased in the 60th min, but no differences were found in fasting values and in the 120th min in the IHA group. There was a significantly higher incidence of impaired glucose tolerance (36 % before, 45 % after treatment) and DM (9 %, 18 %) in the IHA group compared to the APA group (8 %, 32 %; DM 0 %, 0 %). In conclusion, the treatment of PH does not improve glucose tolerance. Mild worsening of glucose tolerance after treatment could be explained by an increase of the body mass index. These data, in accordance with our previous study, do not support the idea that PH is a secondary form of diabetes mellitus., B. Štrauch, J. Widimsky Jr., G. Šindelka, J. Škrha., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
508. Does Vigabatrin Possess an Anticonvulsant Action Against Pentylenetetrazol-Induced Seizures in Developing Rats?
- Creator:
- Renata Haugvicová, Hana Kubová, and Pavel Mareš
- Format:
- print, bez média, and svazek
- Type:
- article, studie, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Vigabatrin, Pentylenetetrazol, Motor seizures, Ontogeny, Rat, 14, and 612
- Language:
- English
- Description:
- Anticonvulsant action of vigabatrin (300, 600, 900 and/or 1200 mg/kg i.p.), an inhibitor of GABA-transaminase, was studied in a model of motor sezures elicited by pentylenetetrazol. Five age groups of rats (7, 12, 18, 25 and 90 days old) received a s.c. injection of pentylenetetrazol 4, 6 and/or 24 hours after vigabatrin administration. The incidence of minimal, predominantly clonic seizures was not changed in any age group, but their latencies were prolonged in 18- and 25-day-old rats. Generalized tonic-clonic seizures were influenced in a more complex manner. Incidence of these seizures was decreased in 7-day-old rat pups 24 hours after vigabatrin administration. Higher doses of vigabatrin exhibited a similar effect in adult rats at all intervals studied. Specific suppression or at least restriction of the tonic phase was observed in all groups of immature rats, the effect was more marked 24 hours after vigabatrin than at shorter intervals. The anticonvulsant action of vigabatrin, which could be demonstrated mainly against generalized tonic-clonic seizures, varies markedly during development., R. Haugvicová, H. Kubová, P. Mareš., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
509. Dojmy pocestné
- Creator:
- Thomayer, Josef
- Publisher:
- Unie
- Format:
- print and 151, i s.
- Type:
- model:monograph and TEXT
- Subject:
- Lékařské vědy. Lékařství, lékařství, cestování, 14, and 61
- Language:
- Czech
- Description:
- Josef Thomayer. and Desky nejsou k dispozici, použity desky z MVS.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
510. Domácí lékárna pro případy náhlého onemocnění
- Creator:
- Lad Šír
- Publisher:
- Tisk a náklad Antonína Čapka
- Format:
- print, text, regular print, and 99 s., 1 vlepený l. ; 15 cm
- Type:
- model:monograph and TEXT
- Subject:
- Fyzioterapie. Psychoterapie. Alternativní lékařství, alternativní terapie, lidové léčitelství, nemoci, 615.8, 615.89, 616.1/.9, (035), and 14
- Language:
- Czech
- Description:
- ve prospěch obecného lidu podává Lad. Šír
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public