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Start Over Creator Pohanka, Miroslav

2. Melatonin regulates oxidative stress initiated by Freund's complete adjuvant

Creator:
Pohanka, Miroslav, Ruttkay-Nedecký, Branislav, Fusek, Josef, Adam, Vojtěch, and Kizek, René
Format:
print, text, and regular print
Type:
model:article, article, Text, časopisecké články, and TEXT
Subject:
adjuvancia imunologická--farmakologie, zvířata, antioxidancia--farmakologie--fyziologie, vztah mezi dávkou a účinkem léčiva, ženské pohlaví, Freundovo adjuvans--farmakologie, melatonin--farmakologie--fyziologie, myši, and oxidační stres--účinky léků--fyziologie
Language:
English
Description:
Melatonin is a hormone with strong antioxidant properties. In this experiment, Freund's complete adjuvant was used as a stressogenic substance given to laboratory outbred mice, whereas melatonin was investigated as a protectant against the stressogenic effect. Levels of low molecular weight antioxidants, thiobarbituric acid reactive substances, and tumor necrosis factor α and activity of glutathione reductase were determined in blood from the animals. Surprisingly, melatonin was not involved in direct regulation of antioxidants, thiobarbituric acid reactive substances and tumor necrosis factor α. On the other hand, melatonin regulated glutathione reductase activity. We can conclude on regulation of metabolism caused by melatonin in the model. The effect was more important than the expected regulation of immunity and basal oxidative homeostasis. and M. Pohanka, B. Ruttkay-Nedecký, J. Fusek, V. Adam, R. Kizek
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3. Possibility of acetylcholinesterase overexpression in Alzheimer disease patients after therapy with acetylcholinesterase inhibitors

Creator:
Kračmarová, Alžběta, Drtinová, Lucie, and Pohanka, Miroslav
Format:
print, text, and regular print
Type:
model:article, article, Text, časopisecké články, přehledy, and TEXT
Subject:
acetylcholin--metabolismus, acetylcholinesteráza--metabolismus, Alzheimerova nemoc--farmakoterapie--metabolismus, centrální nervový systém--účinky léků--metabolismus, inhibitory cholinesteráz--farmakologie, monitorování léků--metody, enzymatické testy, lidé, nootropní látky--farmakologie, and nervový přenos--účinky léků
Language:
English
Description:
Acetylcholinesterase is an enzyme responsible for termination of excitatory transmission at cholinergic synapses by the hydrolyzing of a neurotransmitter acetylcholine. Nowadays, other functions of acetylcholinesterase in the organism are considered, for example its role in regulation of apoptosis. Cholinergic nervous system as well as acetylcholinesterase activity is closely related to pathogenesis of Alzheimer disease. The mostly used therapy of Alzheimer disease is based on enhancing cholinergic function using inhibitors of acetylcholinesterase like rivastigmine, donepezil or galantamine. These drugs can influence not only the acetylcholinesterase activity but also other processes in treated organism. The paper is aimed mainly on possibility of increased expression and protein level of acetylcholinesterase caused by the therapy with acetylcholinesterase inhibitors. and A. Kračmarová, L. Drtinová, M. Pohanka
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public