Oxidative stress may be caused by an increased rate of ATP resynthesis during physical exercise. The aim of this study was to compare changes in the prooxidant-antioxidant state of blood plasma between men and women after maximal-intensity exercise, and to assess the relationship between these changes and the value of the maximal oxygen uptake (VO2max) as well as between these changes and the value of post-exercise disruptions in acid-base balance. Study participants comprised 10 women (20.7±0.5 years) and 10 men (22.3±0.5 years) who were physically active but did no t engage in competitive sports training. VO2max was determined via treadmill incremental test (VO2max relative to body mass: 44.48±1.21 ml/kg/min and 59.16±1.55 ml/kg/min for women and men, respectively). The level of acid-base balance indicators (ABB), lactate concentration (La-), the level of total oxidative status (TOS), the level of total antioxidative capacity (TAC), an d uric acid (UA) concentration were measured before and after the test. An oxidative stress indicator (OSI) was also calculated. Men showed a significant post-exercise increase in the level of TOS and OSI, while women showed a significant post-exercise increase in the level of TAC. Post-exercise changes in UA concentration were insignificant. Post-exercise changes in TOC in men depended on the absolute values of VO2max , on VO2max/LBM, and on post-exercise changes in La- concentration., M. Wiecek, M. Maciejczyk, J. Szymura, Z. Szygula., and Obsahuje bibliografii
The aim of this study was to follow up whether the modification of pro-antioxidant status by oral thiol administration such as N- acetylcysteine and α-lipoic acid affects the hematological response. Twenty-eight healthy men participated in two independent experiments. Subjects were randomly assigned to one of four groups: controls (CNAC and CALA ), N-acetylcysteine (NAC) and α-lipoic acid (ALA). 1200 mg of N-acetylcysteine, 600 mg of α-lipoic acid or placebo were administered for 8 days in two doses. NAC or ALA administration significantly elevated plasma total antioxidant stat us (TAS) and reduced protein carbonylation (PC) and lipid peroxidation (TBARS) by more than 30 %. The reduced glutathione (GSH) and hematological parameters changed only in response to NAC administration. NAC significantly elevated the level of GSH (+33 %), EPO (+26 %), Hb (+9 %) and Hct (+9 %) compared with CNAC. The mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) also increased by more than 12 % after NAC. The numerous negative or positive correlations between the measures of TAS, PC, TBARS and hematological parameters were found, which suggest the NAC-induced interaction between pro-antioxidant and hematological values. Our study has shown that both N-acetylcysteine and α-lipoic acid intake reveal an antioxidant action, but only N-acetylcysteine improves the haematological response., A. Zembron-Lacny ... [et al.]., and Obsahuje seznam literatury