In this paper, we present a novel quantitative description of intracellular and t-tubular Ca2+ dynamics in a model of rat cardiac ventricular myocyte. In order to simulate recently published data, the model incorporates t-tubular and peripheral dyads and intracellular subspaces, segmentation of the t-tubular luminal volume, reformulation of the inactivation properties of t-tubular land peripheral L-type calcium current (ICa) and a description of exogenous Ca2q+ buffer function in the intracellular space. The model is used to explore activity-induced changes of ion concentration in the intracellular and t-tubular spaces and their role in excitation - contraction coupling in ventricular myocytes. and Obsahuje Appendix se seznamy literatury, užitých zkratek a symbolů
Experimentally based models of cardiac cells have been developed since 1960.The early models were based on extension of the Hodgkin-Huxley nerve impulse equations. Including only a few membrane currents they were able to successfully reconstruct the depolarization and repolarization of cellular membrane. Since that time, the models have underwent extensive modifications and reached a high degree of physiological detail. This short review is aimed to outline the history of their development and show the importance of computer modelling for the research in cardiac cell electrophysiology. and Obsahuje seznam literatury