The complex architecture of the liv er biliary network represents a structural prerequisite for the formation and secretion of bile as well as excretion of toxic substances through bile ducts. Disorders of the biliary tract affect a significant portion of the worldwide population, often leading to cholestatic liver diseases. Cholestatic liver disease is a condition that results from an impairment of bile formation or bile flow to the gallbladder and duodenum. Cholestasis leads to dramatic changes in biliary tree architecture, worsening liver disease and systemic illness. Recent studies show that the preva lence of cholestatic liver diseases is increasing. The availability of well characterized animal models, as well as development of visualization approaches constitutes a critical asset to develop novel pathogenetic concepts and new treatment strategies., L. Sarnova, M. Gregor., and Obsahuje bibliografii
Bruno Latour’s article challenges the preconceived notions with which the scholars have approached the Great Divide between prescientific and scientific cultures. In order to account for the immense effects of science and technology without assuming a single grand cause for them, he suggests to focus on many, small unexpected and practical sets of skills to produce images, and to read and write about them. However, only those changes that intervene favorably in the agonistic situation in science should be considered. Crucial in this respect is the emergence of numerous “immutable mobiles” - easily transported, accumulated, combined, yet lasting objects - which made possible the mobilization of new scientific inscriptions and of new ways of looking at and presenting them. They help to constitute an optically consistent visual culture with such technologies as printing press. Their combination on the surface of paper and subsequent mobilization of allies can usher in bureaucratic mode of domination over the world and people in the scientific field. The effects of science and technology thus become a question of a shift in power relations enabled by the manipulation of inscriptions., Bruno, Latour., and Obsahuje bibliografii