Anorexigenic effect of cholecystokinin is lost but that of CART (cocain and amphetamine regulated transcript) peptide is preserved in monosodium glutamate obese mice

Title:

Anorexigenic effect of cholecystokinin is lost but that of CART (cocain and amphetamine regulated transcript) peptide is preserved in monosodium glutamate obese mice

Creator:

Železná, B., Jana Maixnerová, Resha Matyšková, Renata Haugvicová, Blokešová, D., and Lenka Maletínská

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1516e2c4-67a3-4666-884c-54dc43fe9dde
uuid:1516e2c4-67a3-4666-884c-54dc43fe9dde

Subject:

Biochemie. Molekulární biologie. Biofyzika, biochemie, neuropeptidy, biochemistry, neuropeptids, monosodium glutamate (MSG) obesity, neuropeptide Y (NPY), cholecystokinin (CCK), cocaine and amphetamine regulated transcript (CART) peptide, 2, and 577

Type:

article, články, model:article, and TEXT

Description:

Monosodium glutamate (MSG) treatment of neonatal mice results in a selective damage to the arcuate nucleus (ARC) and development of obesity with increased adiposity at sustained body weight in the adulthood. Feeding pattern of the MSG obese mice is unusual. Our previous results showed that after 24-h fasting, MSG mice consumed negligible amount of food in several hours and therefore, it was impossible to register the effect of peptides attenuating food intake such as cholecystokinin (CCK) or cocaine- and amphetamine-regulated transcript (CART) peptide. To overcome this problem, two findings were used: firstly, orexigenic effect of neuropeptide Y (NPY) was attenuated both by CCK or CART peptide in lean fed mice and secondly, orexigenic effect of NPY was preserved in fed rats with MSG obesity. In this study, short-term food intake in fed lean and MSG obese C57BL/6 male mice was measured after simultaneous central administration of orexigenic NPY with either CART peptide or peripherally administered CCK. Anorexigenic action of exogenous CART peptide was preserved in MSG obese mice. On the other hand, satiety effect of exogenous CCK was completely lost in MSG obese mice. In conclusion, effective leptin signaling in ARC is necessary for satiety effect of CCK., B. Železná ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:5

Harvested from:

CDK

Metadata only:

false