May circulating steroids reveal a predisposition to intrahepatic cholestasis of pregnancy in non-pregnant women?

Title:

May circulating steroids reveal a predisposition to intrahepatic cholestasis of pregnancy in non-pregnant women?

Creator:

Patrik Šimják, Miroslav Hill, Antonín Pařízek, Libor Vítek, Marta Velíková, Michaela Dušková, Radmila Kancheva, Josef Bulant, Michal Koucký, Zuzana Kokrdová, Karolína Adamcová, Černý, A, Zdeněk Hájek, and Luboslav Stárka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1bf4e91a-7229-434a-b1dc-5efb93f973e2
uuid:1bf4e91a-7229-434a-b1dc-5efb93f973e2
issn:0862-8408

Subject:

metabolismus steroidů, predikce, steroid metabolism, prediction, intrahepatic cholestasis of pregnancy, liver enzymes, gas chromatography-mass spectrometry, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Intrahepatic cholestasis of pregnancy (ICP) is a frequent liver disorder, mostly occurring in the third trimester. ICP is not harmful to the mothers but threatens the fetus. The authors evaluated steroid alterations in maternal and mixed umbilical blood to elucidate their role in the ICP development. Ten women with ICP were included in the study. Steroids in the maternal blood were measured by Gas Chromatography-Mass Spectrometry (GC-MS) (n=58) and RIA (n=5) at the diagnosis of ICP, labor, day 5 postpartum, week 3 postpartum and week 6 postpartum. The results were evaluated by ANOVA consisting of the subject factor, between subject factors ICP, gestational age at the diagnosis of ICP and gestational age at labor, withinsubject factor Stage and ICP × Stage interaction. The 17 controls were firstly examined in the week 36 of gestation. ICP patients showed reduced CYP17A1 activity in the C17,20 lyase step thus shifting the balance between the toxic conjugated pregnanediols and harmless sulfated 5α/β-reduced-17-oxo C19 steroids. Hence, more toxic metabolites originating in maternal liver from the placental pregnanes may penetrate backward to the fetal circulation. As these alterations persist in puerperium, the circulating steroids could be potentially used for predicting the predisposition to ICP even before next pregnancy., P. Šimják, M. Hill, A. Pařízek, L. Vítek, M. Velíková, M. Dušková, R. Kancheva, J. Bulant, M. Koucký, Z. Kokrdová, K. Adamcová, A. Černý, Z. Hájek, L. Stárka., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false