Relationship between antioxidant potential and oxidative damage to lipids, proteins and DNA in aged rats

Title:

Relationship between antioxidant potential and oxidative damage to lipids, proteins and DNA in aged rats

Creator:

Monika Sivoňová, Tatarková, Z., Zdeňka Ďuračková, Dušan Dobrota, Ján Lehotský, Matáková, T., and Peter Kaplán

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1c5ac8c7-ad08-4c7c-b44a-c3acbf3eb718
uuid:1c5ac8c7-ad08-4c7c-b44a-c3acbf3eb718
issn:0862-8408

Subject:

Biochemie. Molekulární biologie. Biofyzika, fyziologie živočichů, stárnutí, antioxidanty, peroxidázy, animal physiology, aging, antioxidants, peroxidases, comet assay, total sulfhydryl groups, 2, and 577

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Oxidative stress has been implicated to play a major role in aging and age-related diseases. In the present study, we investigated the effects of aging on the total antioxidant capacity, uric acid, lipid peroxidation, total sulfhydryl group content and damage to DNA in adult (6 months), old (15 months) and senescent (26 months) male Wistar rats. The antioxidant capacity, determined by phycoerythrin-based TRAP method (total peroxyl radical-trapping potential) was significantly decreased in the plasma and myocardium of old and senescent rats, whereas plasma level of uric acid was elevated in 26-month-old rats. Age-related decline in plasma and heart antioxidant capacity was accompanied by a significant loss in total sulfhydryl group content, increased lipid peroxidation and higher DNA damage in lymphocytes. Correlations between TRAP and oxidative damage to lipids, proteins and DNA suggest that the decline in antioxidant status may play an important role in age-related accumulation of cell damage caused by reactive oxygen species., M. Sivoňová, Z. Tatarková, Z. Ďuračková, D. Dobrota, J. Lehotský, T. Matáková, P. Kaplán., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:6

Harvested from:

CDK

Metadata only:

false