Non-woven PGA/PVA fibrous mesh as an appropriate scaffold for chondrocyte proliferation

Title:

Non-woven PGA/PVA fibrous mesh as an appropriate scaffold for chondrocyte proliferation

Creator:

Michala Rampichová, Eva Košťáková, Elena Filová, Eva Prosecká, Martin Plencner, Ocheretná, L., Lytvynets, A., David Lukáš, and Evžen Amler

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:3888ab96-b2aa-44b7-ae25-0024e4b72a9d
uuid:3888ab96-b2aa-44b7-ae25-0024e4b72a9d

Subject:

Fyziologie člověka a srovnávací fyziologie, chondrocyty, tkáňové inženýrství, chondrocytes, tissue engineering, PGA, PVA, non-woven textile, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Non-woven textile mesh from polyglycolic acid (PGA) was found as a proper material for chondrocyte adhesion but worse for their proliferation. Neither hyaluronic acid nor chitosan nor polyvinyl alcohol (PVA) increased chondrocyte adhesion. However, chondrocyte proliferation suffered from acidic byproducts of PGA degradation. However, the addition of PVA and/or chitosan into a wet-laid non-woven textile mesh from PGA improved chondrocyte proliferation seeded in vitro on the PGA-based composite scaffold namely due to a diminished acidification of their microenvironment. This PVA/PGA composite mesh used in combination with a proper hydrogel minimized the negative effect of PGA degradation without dropping positive parameters of the PGA wet-laid non-woven textile mesh. In fact, presence of PVA and/or chitosan in the PGA-based wet-laid non-woven textile mesh even advanced the PGA-based wet-laid non-woven textile mesh for chondrocyte seeding and artificial cartilage production due to a positive effect of PVA in such a scaffold on chondrocyte proliferation., M. Rampichová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:5

Harvested from:

CDK

Metadata only:

false