Spectral peak frequency in low-frequency band in cross spectra of blood pressure and heart rate fluctuations in young type 1 diabetic patients

Title:

Spectral peak frequency in low-frequency band in cross spectra of blood pressure and heart rate fluctuations in young type 1 diabetic patients

Creator:

Nataša Honzíková, Krtička, A., Eva Závodná, Michal Javorka, Ingrid Tonhajzerová, and Kamil Javorka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:38aa6830-82bf-4813-b73c-22f9c104ea38
uuid:38aa6830-82bf-4813-b73c-22f9c104ea38

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, type 1 diabetes mellitus, baroreflex sensitivity, cross-spectral analysis, frequency of spectral peak, receiver operating curve, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

In this study we tested whether joint evaluation of the frequency (fcs) at which maxima of power in the cross-spectra between the variability in systolic blood pressure and inter-beat intervals in the range of 0.06-0.12 Hz occur together with the quantification of baroreflex sensitivity (BRS) may improve early detection of autonomic dysfunction in type 1 diabetes mellitus (T1DM). We measured 14 T1DM patients (age 20.3-24.2 years, DM duration 10.4-14.2 years, without any signs of autonomic neuropathy) and 14 age-matched controls (Co). Finger arterial blood pressure was continuously recorded by Finapres for one hour. BRS and fcs were determined by the spectral method. Receiver-operating curves (ROC) were calculated for fcs, BRS, and a combination of both factors determined as F(z)=1/(1+exp(-z)), z=3.09–0.013*BRS– 0.027*fcs. T1DM had significantly lower fcs than Co (T1DM: 88.8±6.7 vs. Co: 93.7±3.8 mHz; p<0.05), and a tendency towards lower BRS compared to Co (T1DM: 10.3±4.4 vs. Co: 14.6±7.1 ms/mm Hg; p=0.06). The ROC for Fz showed the highest sensitivity and specificity (71.4 % and 71.4 %) in comparison with BRS (64.3 % and 71.4 %) or fcs (64.3 % and 64.3 %). The presented method of evaluation of BRS and fcs forming an integrated factor Fz could provide further improvement in the risk stratification of diabetic patients., N. Honzíková ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:4

Harvested from:

CDK

Metadata only:

false